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公开(公告)号：US20200000910A1
公开(公告)日：2020-01-02
申请号：US16551991
申请日：2019-08-27
发明人： Ram URITSKI , Barry COHEN , Zohar GADRI , Shimon HASSIN
IPC分类号： A61K39/145 , A61K9/16 , C12N7/00
摘要： The present invention relates to pharmaceutical comprising multimeric-multiepitope influenza polypeptides, to processes for their production and to their use as immunizing subjects against influenza. In particular, the invention relates to stable aqueous microparticulate suspensions and solid compositions comprising a multimeric multiepitope polypeptide.
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公开(公告)号：US10426828B2
公开(公告)日：2019-10-01
申请号：US15300529
申请日：2015-04-01
发明人： Ram Uritski , Barry Cohen , Zohar Gadri , Shimon Hassin
摘要： Pharmaceutical suspensions of multimeric-multiepitope influenza polypeptides, processes for their production and their use as immunizing subjects against influenza. In particular, stable aqueous microparticulate suspensions of a multimeric multiepitope polypeptide are disclosed.
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公开(公告)号：US20170173142A1
公开(公告)日：2017-06-22
申请号：US15300529
申请日：2015-04-01
发明人： Ram URITSKI , Barry COHEN , Zohar GADRI , Shimon HASSIN
CPC分类号： A61K39/12 , A61K9/0019 , A61K9/10 , A61K47/183 , A61K2039/55511 , C12N7/00 , C12N2760/16034 , C12N2760/16134 , C12N2760/16234
摘要： Pharmaceutical suspensions of multimeric-multiepitope influenza polypeptides, processes for their production and their use as immunizing subjects against influenza. In particular, stable aqueous microparticulate suspensions of a multimeric multiepitope polypeptide are disclosed.
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公开(公告)号：US09353159B2
公开(公告)日：2016-05-31
申请号：US14263359
申请日：2014-04-28
发明人： Tamar Ben-Yedidia , Yossi Singer
IPC分类号： C07H21/04 , A61K39/145 , A61K39/00 , A61K39/12 , A61K39/295 , C07K14/005
CPC分类号： C07K14/005 , A61K39/12 , A61K39/145 , A61K2039/53 , A61K2039/55566 , A61K2039/57 , A61K2039/645 , C12N2760/16034 , C12N2760/16134 , C12N2760/16234
摘要： An isolated polynucleotide encoding an influenza multi-epitope polypeptide, wherein the multi-epitope polypeptide comprises multiple copies of a plurality of influenza virus peptide epitopes wherein the polypeptide is B(X1ZX2Z . . . Xm)nB or B(X1)nZ(X2)nZ . . . (Xm)nB; wherein B is an optional sequence of 1-4 amino acid residues; n is at each occurrence independently an integer of 2-50; m is an integer of 3-15; each of X1, X2 . . . Xm is an influenza peptide epitope of 4-24 amino acid residues; and Z at each occurrence is a bond or a spacer of 1-4 amino acid residues.
摘要翻译： 编码流感多表位多肽的分离的多核苷酸，其中多表位多肽包含多个流感病毒肽表位的多个拷贝，其中多肽是B（X1ZX2Z ... Xm）nB或B（X1）nZ（X2） nZ。 。 。 （Xm）nB; 其中B是1-4个氨基酸残基的任选序列; n在每次出现时独立地为2-50的整数; m为3-15的整数; 每个X1，X2。 。 。 Xm是4-24个氨基酸残基的流感肽表位; Z在每次出现时是1-4个氨基酸残基的键或间隔基。
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公开(公告)号：US20140286982A1
公开(公告)日：2014-09-25
申请号：US14263359
申请日：2014-04-28
发明人： Tamar BEN-YEDIDIA , Yossi SINGER
IPC分类号： C07K14/005
CPC分类号： C07K14/005 , A61K39/12 , A61K39/145 , A61K2039/53 , A61K2039/55566 , A61K2039/57 , A61K2039/645 , C12N2760/16034 , C12N2760/16134 , C12N2760/16234
摘要： An isolated polynucleotide encoding an influenza multi-epitope polypeptide, wherein the multi-epitope polypeptide comprises multiple copies of a plurality of influenza virus peptide epitopes wherein the polypeptide is B(X1ZX2Z . . . Xm)nB or B(X1)nZ(X2)nZ . . . (Xm)nB; wherein B is an optional sequence of 1-4 amino acid residues; n is at each occurrence independently an integer of 2-50; m is an integer of 3-15; each of X1, X2 . . . Xm is an influenza peptide epitope of 4-24 amino acid residues; and Z at each occurrence is a bond or a spacer of 1-4 amino acid residues.
摘要翻译： 编码流感多表位多肽的分离的多核苷酸，其中多表位多肽包含多个流感病毒肽表位的多个拷贝，其中多肽是B（X1ZX2Z ... Xm）nB或B（X1）nZ（X2） nZ。 。 。 （Xm）nB; 其中B是1-4个氨基酸残基的任选序列; n在每次出现时独立地为2-50的整数; m为3-15的整数; 每个X1，X2。 。 。 Xm是4-24个氨基酸残基的流感肽表位; Z在每次出现时是1-4个氨基酸残基的键或间隔基。
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