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公开(公告)号：US20220013343A1
公开(公告)日：2022-01-13
申请号：US17186650
申请日：2021-02-26
申请人： Bruker Daltonik GmbH
发明人： Tobias BOSKAMP
IPC分类号： H01J49/00 , G01N33/483
摘要： The disclosure relates to a method for processing a mass spectrum, comprising: (i) providing the mass spectrum which contains a plurality of data pairs, each data pair being representative of a mass value or mass-related value on a mass scale or mass-related scale and an abundance value or abundance-related value associated with the respective mass value or mass-related value, (ii) selecting a plurality of intervals on the mass scale or mass-related scale, each interval containing a multitude of the said data pairs, (iii) for each interval, applying a first mathematical-statistical analysis to the said data pairs contained in the respective interval in order to derive an interval-specific peak width, and (iv) using the said interval-specific peak widths to determine an estimated peak width for each mass value or mass-related value on the mass scale or mass-related scale.
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公开(公告)号：US20210217601A1
公开(公告)日：2021-07-15
申请号：US17219230
申请日：2021-03-31
申请人： Bruker Daltonik GmbH
摘要： The invention relates to methods for drawing-off liquid from individual droplets which are in a predefined arrangement on a flat substrate and have sedimented material enclosed in them. A mask of an absorbent material comprising a pattern of indentations or holes which corresponds at least partially to the regular arrangement of the individual droplets, or a stiff, rigid plate of an absorbent material is positioned above the flat substrate in such a way that the droplets come into contact with the absorbent material peripherally so that liquid is drawn off there-into. The invention also relates to a mask of an absorbent material with a substantially rectangular shape which has a predefined pattern of indentations or holes for the purpose of separating liquid and sedimented material enclosed therein.
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3.发明授权公开(公告)号：US11049705B2
公开(公告)日：2021-06-29
申请号：US16359491
申请日：2019-03-20
申请人： Bruker Daltonik GmbH
发明人： Sebastian Böhm , Andreas Haase , Jens Höhndorf
摘要： The disclosure relates to a method of operating a secondary-electron multiplier in the ion detector of a mass spectrometer so as to prolong the service life, wherein the secondary-electron multiplier is supplied with an operating voltage in such a way that an amplification of less than 106 secondary electrons per impinging ion results, while the output current of the secondary-electron multiplier is amplified using an electronic preamplifier mounted close to the secondary-electron multiplier with such a low noise level that the current pulses of individual ions impinging on the ion detector are detected above the noise at the input of a digitizing unit. Further disclosed are the use of the methods for imaging mass spectrometric analysis of a thin tissue section or mass spectrometric high-throughput analysis/massive-parallel analysis, and a time-of-flight mass spectrometer whose control unit is programmed to execute such methods.
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公开(公告)号：US11017993B2
公开(公告)日：2021-05-25
申请号：US15912694
申请日：2018-03-06
申请人： Bruker Daltonik GmbH
摘要： The invention relates to methods for drawing-off liquid from individual droplets which are in a predefined arrangement on a flat substrate and have sedimented material enclosed in them. A mask of an absorbent material comprising a pattern of indentations or holes which corresponds at least partially to the regular arrangement of the individual droplets, or a stiff, rigid plate of an absorbent material is positioned above the flat substrate in such a way that the droplets come into contact with the absorbent material peripherally so that liquid is drawn off there-into. The invention also relates to a mask of an absorbent material with a substantially rectangular shape which has a predefined pattern of indentations or holes for the purpose of separating liquid and sedimented material enclosed therein.
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公开(公告)号：US10937639B2
公开(公告)日：2021-03-02
申请号：US16429576
申请日：2019-06-03
申请人： Bruker Daltonik GmbH
发明人： Jens Decker
摘要： The invention relates to selection of precursors from a measured mobility-mass map for tandem mass spectrometry and is based on processing a peak list from measured signals and clustering these peaks in the mobility-mass space.
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公开(公告)号：US20200381229A1
公开(公告)日：2020-12-03
申请号：US16888137
申请日：2020-05-29
申请人： Bruker Daltonik GmbH
IPC分类号： H01J49/00 , G01N27/64 , B01D59/44 , G01N33/483
摘要： The invention relates to a method for the determination and visualization of the spatial distribution of tissue states of a tissue sample, wherein a mass/mobility map is acquired at each of a plurality of sample sites of the tissue sample, the signal heights at each sample site are determined at characteristic signal positions in the corresponding mass/mobility map, from which a tissue state for each sample site is calculated with the aid of a mathematical/statistical classification algorithm, and the spatial distribution of the tissue states calculated for the sample sites is represented graphically.
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公开(公告)号：US20200328069A1
公开(公告)日：2020-10-15
申请号：US16826966
申请日：2020-03-23
申请人： Bruker Daltonik GmbH
发明人： Tobias BOSKAMP
摘要： The disclosure relates to a method which is suitable for the quality control and signal correction of mass spectrometry data of biological tissue samples and is based on the analysis of the chemical background signal observed in a spectrum. It exploits the fact that the chemical background signal contains components from a plurality of polymer molecules, whose chemical structure has strong regularities. These regularities mean that the observed masses are subject to certain statistical distributions, which are each characteristic of the class of molecule. By analyzing these statistical properties, it is possible to detect and correct any mass shifts which may be present.
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公开(公告)号：US20200327961A1
公开(公告)日：2020-10-15
申请号：US16838386
申请日：2020-04-02
申请人： Bruker Daltonik GmbH
发明人： Detlev SUCKAU
摘要： The present invention relates to a mass spectrometric method for determining isomeric amino acid residues of a peptide and comprises the steps of: generating a list of peptide candidates using the amino acid lead sequence of the peptide, said lead sequence comprising positions of determined amino acid residues and at least one position with undetermined isomeric amino acid residues; predicting the collision cross section for each peptide candidate; comparing the predicted collision cross section of each peptide candidate with an experimentally determined collision cross section of the peptide and assigning the isomeric amino acid residues of the best matching peptide candidate to the isomeric amino acid residues of the peptide.
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公开(公告)号：US10796896B2
公开(公告)日：2020-10-06
申请号：US16422821
申请日：2019-05-24
申请人： Bruker Daltonik GmbH
发明人： Sebastian Böhm
摘要： The invention relates to time-of-flight mass spectrometers with pulsed ionization of samples, for example by matrix-assisted laser desorption (MALDI), where the samples are located on a sample support and are irradiated and ionized one after the other in a grid by a position-controlled desorption beam. An ion-optical puller lens arrangement is positioned in front of the sample support, with at least one of the lens diaphragms in the arrangement being subdivided into segments, and a voltage supply being able to supply the segments, or some of them, with different voltages, depending on the impact position of the desorption beam on the support plate. It is then possible to virtually shift the effective ion-optical focusing center of the lens away from the axis, and to focus an ion beam, which is generated off the real lens axis, into a beam which runs essentially parallel to the real lens axis, with no time phase shift for ions of the same mass. This beam can be brought back onto the axis by an x/y deflection unit, for example for operating the time-of-flight mass spectrometer with a reflector.
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公开(公告)号：US20200058479A1
公开(公告)日：2020-02-20
申请号：US16525165
申请日：2019-07-29
申请人： Bruker Daltonik GmbH
发明人： Urs STEINER , Jochen FRANZEN
摘要： The invention relates to turbo molecular pumps enabling high pumping speed. The disclosure suggests using one or more cage-like rotor stages to optimize pumping speed on vacuum systems with low gas flows and low ultimate pressures. This allows for a smaller motor as well as smaller overall form factor and makes it well suited, in particular, for compact mass spectrometers and desk-top mass spectrometers.
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