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公开(公告)号：US20200232889A1
公开(公告)日：2020-07-23
申请号：US16741899
申请日：2020-01-14
申请人： Bruker Daltonik GmbH
发明人： Alexander VOSSGRÖNE
摘要： The invention relates to a method for sample preparation on a spectrometric sample support, comprising the steps of: (i) providing the sample support with an arrangement of individual liquid droplets, for example of washing liquid or nutrient solution, each of which has microorganism sediments enclosed in it; (ii) locating a plate of an absorbent material containing cotton fibers, for example, above the sample support; (iii) lowering the plate vertically onto the sample support in such a way that microorganism sediments and plate come into contact, whereby the droplets of liquid are absorbed into the absorbent material; (iv) lifting the plate, which is locally enriched with droplet liquid, off the sample support, thereby exposing the microorganism sediments that are depleted of liquid; and (v) preparing the exposed microorganism sediments for spectrometric measurement, by means of infrared spectrometry or MALDI time-of-flight mass spectrometry, for example.
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公开(公告)号：US20210217601A1
公开(公告)日：2021-07-15
申请号：US17219230
申请日：2021-03-31
申请人： Bruker Daltonik GmbH
摘要： The invention relates to methods for drawing-off liquid from individual droplets which are in a predefined arrangement on a flat substrate and have sedimented material enclosed in them. A mask of an absorbent material comprising a pattern of indentations or holes which corresponds at least partially to the regular arrangement of the individual droplets, or a stiff, rigid plate of an absorbent material is positioned above the flat substrate in such a way that the droplets come into contact with the absorbent material peripherally so that liquid is drawn off there-into. The invention also relates to a mask of an absorbent material with a substantially rectangular shape which has a predefined pattern of indentations or holes for the purpose of separating liquid and sedimented material enclosed therein.
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公开(公告)号：US20150075564A1
公开(公告)日：2015-03-19
申请号：US14483223
申请日：2014-09-11
申请人： Bruker Daltonik GmbH
CPC分类号： H01J49/0431 , B01L3/021 , B01L3/0241 , B01L2200/0615 , B01L2300/0654 , G01N35/1004 , H01J49/0418 , H01J49/26
摘要： The invention relates to the preparation of samples on mass spectrometric sample supports with dispensing of liquids, and particularly to devices and methods to clean the dispenser. During dispensing of hundreds of samples, solved material may crystallize over time as deposit at the capillary tip of the dispenser, which impedes the vertical detachment of the drop in the medium and long run. Therefore, frequently cleaning the capillary tip is essential for a robust operation of the preparation device. The invention proposes to automatically clean the dispenser tip by creating a drop of washing fluid, such as pure solvent, fully enclosing the dispenser tip. The washing fluid is fed through a channel outside the central dispenser capillary to a location slightly above the capillary tip. The size of the hanging drop of washing fluid is photometrically regulated and monitored to prevent it from falling off prematurely.
摘要翻译： 本发明涉及在分配液体的质谱样品支架上制备样品，特别涉及清洁分配器的装置和方法。 在分配数百个样品期间，溶解的材料随着时间的推移可能随着分配器的毛细管尖端沉积而结晶，这阻碍了介质中的液滴的垂直分离并长期运行。 因此，经常清洁毛细管尖端对于制备装置的鲁棒操作是必需的。 本发明提出通过产生完全包围分配器尖端的一滴洗涤液（例如纯溶剂）来自动清洁分配器尖端。 洗涤液通过中央分配器毛细管外部的通道进入到略高于毛细管尖端的位置。 清洗液悬挂液滴的大小被光度调节和监测，以防过早脱落。
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公开(公告)号：US20180374692A1
公开(公告)日：2018-12-27
申请号：US16121053
申请日：2018-09-04
申请人： Bruker Daltonik GmbH
CPC分类号： H01J49/0431 , B01L3/021 , B01L3/0241 , B01L2200/0615 , B01L2300/0654 , G01N35/1004 , H01J49/0418 , H01J49/26
摘要： The invention relates to the preparation of samples on mass spectrometric sample supports with dispensing of liquids, and particularly to devices and methods to clean the dispenser. During dispensing of hundreds of samples, solved material may crystallize over time as deposit at the capillary tip of the dispenser, which impedes the vertical detachment of the drop in the medium and long run. Therefore, frequently cleaning the capillary tip is essential for a robust operation of the preparation device. The invention proposes to automatically clean the dispenser tip by creating a drop of washing fluid, such as pure solvent, fully enclosing the dispenser tip. The washing fluid is fed through a channel outside the central dispenser capillary to a location slightly above the capillary tip. The size of the hanging drop of washing fluid is photometrically regulated and monitored to prevent it from falling off prematurely.
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公开(公告)号：US20180269050A1
公开(公告)日：2018-09-20
申请号：US15912694
申请日：2018-03-06
申请人： Bruker Daltonik GmbH
CPC分类号： H01J49/0418 , B01J2219/00315 , B01L3/5085 , G01N1/2813
摘要： The invention relates to methods for drawing-off liquid from individual droplets which are in a predefined arrangement on a flat substrate and have sedimented material enclosed in them. A mask of an absorbent material comprising a pattern of indentations or holes which corresponds at least partially to the regular arrangement of the individual droplets, or a stiff, rigid plate of an absorbent material is positioned above the flat substrate in such a way that the droplets come into contact with the absorbent material peripherally so that liquid is drawn off there-into. The invention also relates to a mask of an absorbent material with a substantially rectangular shape which has a predefined pattern of indentations or holes for the purpose of separating liquid and sedimented material enclosed therein.
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