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公开(公告)号：US20230042677A1
公开(公告)日：2023-02-09
申请号：US17794691
申请日：2021-01-20
申请人： Bayer Oy
发明人： Mikael STOLT , Taina TJÄDER , Christine TALLING , Risto HAKALA , Heikki SALO , Mira KAUTTO , Marina ALLEN , Jari RISKI , Petri PERÄLÄ
IPC分类号： A61F6/14
摘要： Disclosed is an intrauterine system (100, 300, 400, 500, 600) comprising a frame (102, 302, 402, 502, 602), a removal thread (218, 326, 436, 626) and at least one pharmaceutically active agent. The frame has a first end (104, 304, 404, 504, 604), a second end (106, 306, 406, 506, 606) and a length L. The first end of the frame comprises a first locking part (108, 308, 408, 508, 608) and the second end of the frame comprises a second locking part (110, 310, 410, 510, 610), the first locking part and the second locking part being arranged to form a lock (202, 312, 432). The removal thread is attached to the first end of the frame. The removal thread is configured to guide the first locking part to the second locking part. Further, disclosed is a kit comprising the aforementioned intrauterine system and an inserter.
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公开(公告)号：US20230039977A1
公开(公告)日：2023-02-09
申请号：US17794683
申请日：2021-01-20
申请人： Bayer Oy
发明人： Taina TJÄDER , Mikael STOLT , Heikki SALO , Mira KAUTTO , Marina ALLEN , Kimmo LAAKSONEN , Jari RISKI , Petri PERÄLÄ
IPC分类号： A61F6/18
摘要： Disclosed is an inserter (1100, 1300, 1400, 1500) for an intrauterine system (1102, 1336, 1402, 1502), comprising a handle body (1104, 1306, 1416, 1504), a measurement tube (1110, 1328, 1406, 1510), a plunger (1132, 1202, 1362, 1450, 1532), a flange (1122, 1404, 1522), a finger holder (1124, 1314, 1446, 1524), and a means (1126, 1526) for reversibly locking removal thread (1128, 1358, 1414) of the intrauterine system. A proximal end (1106, 1440, 1506) of the measurement tube is movably attached to a distal end (1108, 1330, 1454, 1508) of the handle body, and the measurement tube is arranged to remain outside a cervix channel during insertion. The plunger is movably arranged inside the handle body and the measurement tube. The present disclosure also provides a kit comprising the inserter and the intrauterine system.
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公开(公告)号：US20220265466A1
公开(公告)日：2022-08-25
申请号：US17743249
申请日：2022-05-12
申请人： Bayer Oy
摘要： The invention relates to an inserter for an intrauterine system, comprising a handle (3) having a longitudinal opening (8) at its first end, said opening (8) having a longitudinal axis parallel to the longitudinal axis of the inserter, a first end (8a) and a second end (8b), a moveable slider (5) arranged in said longitudinal opening (8) and having a first end (5a) and a second end (5b), a plunger (2) attached to the handle (3), an insertion tube (6) arranged around the plunder (2) having a first end and a second end, with its second end attached to the slider (5), wherein the inserter further comprises locking means for reversibly locking the intrauterine system in relation to the plunder (2) via a removal string of the intrauterine system, said locking means being controllable by the slider (5) and/or the insertion tube (6).
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公开(公告)号：US20210307957A1
公开(公告)日：2021-10-07
申请号：US17239417
申请日：2021-04-23
申请人： Bayer Oy
摘要： The invention relates to an inserter for an intrauterine system, comprising a handle (3) having a longitudinal opening (8) at its first end, said opening (8) having a longitudinal axis parallel to the longitudinal axis of the inserter, a first end (8a) and a second end (8b), a moveable slider (5) arranged in said longitudinal opening (8) and having a first end (5a) and a second end (5b), a plunger (2) attached to the handle (3), an insertion tube (6) arranged around the plunder (2) having a first end and a second end, with its second end attached to the slider (5), wherein the inserter further comprises locking means for reversibly locking the intrauterine system in relation to the plunder (2) via a removal string of the intrauterine system, said locking means being controllable by the slider (5) and/or the insertion tube (6).
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公开(公告)号：US11135085B2
公开(公告)日：2021-10-05
申请号：US16341044
申请日：2017-10-10
申请人： BAYER OY
发明人： Joonas Mikkonen , Tero Jalkanen , Mikko Virtanen , Taina Tjäder , Karym El Sayed
摘要： Disclosed are an inserter and an inserter kit for an intrauterine system. The inserter comprises an insertion tube having a first end and an opposite second end, wherein the first end is operable to removably receive the intrauterine system and a handle having a first end portion and an opposite second end portion, the first end portion of the handle is coupled to the second end of the insertion tube. The handle comprises a handling mechanism for controlling movement of the insertion tube with respect to the intrauterine system. The inserter also comprises an indicating mechanism operatively arranged in connection with the insertion tube and the handle, the indicating mechanism is communicably coupled to the handling mechanism and is operable to provide indicative signals corresponding to operational stages of the inserter. The indicative signals comprise at least one light signal and the indicating mechanism comprises a power source.
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公开(公告)号：US20210298942A1
公开(公告)日：2021-09-30
申请号：US17239428
申请日：2021-04-23
申请人： Bayer Oy
摘要： An inserter for an intrauterine system can include a handle having an opening, a slider arranged in the opening, a plunger attached to the handle, an insertion tube attached to the slider and arranged around the plunger, and a lock adapted to reversibly lock at least one removal string of the intrauterine system. The lock can include a main part comprising an opening, the main part being rotatably mounted on a shaft or axle, an extension of the main part, and a counterpart. The at least one removal string passes through the opening of the main part and is immobilized between the main part and the counterpart when the lock is in a locking position. The slider is configured to press against the extension of the main part and turn the main part around the shaft or axle to release the at least one removal string as the slider is moved backwards.
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公开(公告)号：US10248525B2
公开(公告)日：2019-04-02
申请号：US15729028
申请日：2017-10-10
申请人： BAYER OY
发明人： Joonas Mikkonen , Tero Jalkanen , Mikko Virtanen , Taina Tjäder , Karym El Sayed , Arto Pakkalin
IPC分类号： G08B1/08 , G06F11/30 , A61F6/20 , A61M37/00 , A61B1/05 , A61B1/06 , A61B1/00 , A61B17/34 , A61B90/98 , A61B34/20 , A61F2/82 , G06F17/30 , H04L29/08
摘要： An intelligent medical implant and monitoring system includes an implant with a communication device, an inserter for inserting the implant, a reader that operates to broadcast a signal specific to the particular communication device that causes the communication device to respond with a unique identifier, and an external database for storing and providing access to information keyed to the unique identifier of the communication device.
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公开(公告)号：US20180014966A1
公开(公告)日：2018-01-18
申请号：US15647104
申请日：2017-07-11
申请人： Bayer Oy
发明人： Heikki Lyytikäinen , Ilkka Jutila , Ulla Calvo Alonso , Harri Jukarainen , Taina Tjäder , Andrew Macleod , Michael Noble , David Whitaker
摘要： The present invention relates to an inserter for an intrauterine system, comprising a handle (3) having a longitudinal opening (8) at its first end, said opening (8) having a longitudinal axis parallel to the longitudinal axis of the inserter, a first end (8 a) and a second end (8 b), a movable slider (5) arranged in said longitudinal opening (8) and having a first end (5 a) and a second end (5 b), a plunger (2) attached to the handle (3) and having a longitudinal axis, and an insertion tube (6) having a first end, a second end and a longitudinal axis essentially parallel to the longitudinal axis of the plunger (2), the insertion tube (6) being, along said longitudinal axis, movably arranged around the plunger (2). The invention is characterised in that it further comprises a flange (4) arranged on the insertion tube (6) at its first end, and means for locking the slider (5) into a position showing the correct insertion depth for the intrauterine system, said means being adjustable with respect to the opening (8) of the handle.
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10.发明申请公开(公告)号：US20180008536A1
公开(公告)日：2018-01-11
申请号：US15544326
申请日：2016-01-20
申请人： BAYER OY
发明人： Harri JUKARAINEN , Jyrki PIHLAJA , Svante HOLMBERG , Tuula VALO , Anu-Liisa HONKA , Jenny HOLLAENDER
IPC分类号： A61K9/00 , A61K9/70 , A61K31/405 , A61K47/34 , A61K47/32 , A61K31/567 , B29L31/00 , B29K23/00 , B29K105/00
CPC分类号： A61K9/0039 , A61K9/70 , A61K31/405 , A61K31/567 , A61K47/32 , A61K47/34 , B29C64/106 , B29C64/118 , B29K2023/083 , B29K2105/0035 , B29L2031/753 , B33Y10/00 , B33Y80/00
摘要： The invention is describing an intrauterine delivery system comprising non-steroidal anti-inflammatory (NSAID) and a progestogenic compound, containing anti-inflammatory active compound in the frame material and that the progestogenic compound is contained in a silicon based reservoir attached to the frame, wherein the frame consist of a thermoplastic material. A further object of the invention is to fabricate drug-containing T-intrauterine systems (I US) with the drug incorporated within the entire backbone of the medical device by using 3D printing technique, based on fused deposition modelling (FDM™). Indomethacin was used to prepare drug-loaded poly-caprolactone (PCL)-based filaments with different drug contents 5-40 wt %, namely 5%, 15% and 30% wt %: of Indomethacin.
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