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1.发明授权4-substituted azetidinones as precursors to 2-substituted-3-carboxy carbapenem antibiotics and a method of producing them 失效4-取代的氮杂环丁酮作为2-取代-3-羧基碳青霉烯类抗生素的前体及其制备方法
公开(公告)号：US5700930A
公开(公告)日：1997-12-23
申请号：US420955
申请日：1995-04-12
IPC分类号： C07D205/08 , C07D477/04 , C07F7/18 , C07F9/568 , C07D477/00 , C07D409/06 , C07D463/00
CPC分类号： C07D205/08 , C07D477/04 , C07F7/1856 , C07F7/186 , C07F9/568
摘要： New 4-substituted azetidinones having the formulae I and II: ##STR1## wherein X is oxygen, sulfur or a moiety of the formula NR.sup.6 where R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are defined hereafter, which are intermediates for the preparation of carbapenem and carbacephem antibacterials and processes for producing such antibacterials through the utilization of an acid mediated ring closure reaction.
摘要翻译： 具有式I和II的新的4-取代的氮杂环丁酮：其中X是氧，硫或式NR6的部分，其中R 1，R 2，R 3，R 4，R 5和R 6在下文中定义，其中 是用于制备碳青霉烯类和碳青霉烯类抗生素的中间体以及通过利用酸介导的闭环反应产生这种抗菌剂的方法。
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2.发明授权4-substituted azetidinones as precursors to 2-substituted-3-carboxy carbapenem antibiotics and a method of producing them 失效4-取代的氮杂环丁酮作为2-取代-3-羧基碳青霉烯类抗生素的前体及其制备方法
公开(公告)号：US5656753A
公开(公告)日：1997-08-12
申请号：US295329
申请日：1994-08-24
IPC分类号： C07D205/08 , C07D477/04 , C07F7/18 , C07F9/568 , C07D477/00 , C07D463/00 , C07D409/06
CPC分类号： C07D205/08 , C07D477/04 , C07F7/1856 , C07F7/186 , C07F9/568
摘要： Compounds of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.4, R.sup.5, R.sup.12, R.sup.16 and R.sup.17 are defined in the specification are provided. These compounds are useful as intermediates for the preparation of carbapenem antibacterials.
摘要翻译： 提供了在说明书中定义的其中R 1，R 2，R 4，R 5，R 12，R 16和R 17的化学式“IMAGE”
的化合物。 这些化合物可用作制备碳青霉烯类抗菌药物的中间体。 -
公开(公告)号：US5750735A
公开(公告)日：1998-05-12
申请号：US445388
申请日：1995-05-19
申请人： Yang-I Lin , Panayota Bitha , Subas Sakya , Timothy W. Strohmeyer , Karen Bush , Carl Bernard Ziegler , Gregg Brian Feigelson
发明人： Yang-I Lin , Panayota Bitha , Subas Sakya , Timothy W. Strohmeyer , Karen Bush , Carl Bernard Ziegler , Gregg Brian Feigelson
IPC分类号： A61K31/40 , A61K31/397 , A61K31/4015 , A61K31/403 , A61K31/42 , A61K31/425 , A61K31/44 , A61K31/495 , A61K31/535 , A61P31/00 , A61P31/04 , C07D307/18 , C07D333/34 , C07D333/48 , C07D477/00 , C07D477/04 , C07D477/06 , C07D477/12 , C07D477/14 , C07D477/20 , C07F9/6561 , C07H11/00 , C07H19/01 , C07D307/02
CPC分类号： C07D307/18 , C07D333/34 , C07D477/14 , C07F9/65611 , C07H11/00 , C07H19/01 , Y02P20/582
摘要： Carbapenem antibiotic compounds of the general formula: ##STR1## wherein the moiety ##STR2## is a 4, 5 or 6 membered mono, di- or tri-substituted oxygen or sulfur containing ring; wherein Z is oxygen, sulfur, sulfoxide and sulfone, pharmaceutical compositions thereof useful for the treatment of bacterial infections, processes for preparing the compounds and new intermediates useful in the process.
摘要翻译： 具有以下通式的卡巴培南抗生素化合物：其中部分“IMAGE”是4,5或6元单，二或三取代的含氧或含硫环; 其中Z是氧，硫，亚砜和砜，其用于治疗细菌感染的药物组合物，用于制备化合物的方法和可用于该方法的新中间体。
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4.发明授权Method of inhibiting a .beta.-lactamase enzyme by administering novel 2-thiosubstituted carbapenems 失效通过施用新的2-取代的碳青霉烯类来抑制β-内酰胺酶的方法
公开(公告)号：US5744465A
公开(公告)日：1998-04-28
申请号：US448295
申请日：1995-05-23
申请人： Yang-I Lin , Panayota Bitha , Subas Sakya , Timothy W. Strohmeyer , Karen Bush , Carl Bernard Ziegler , Gregg Brian Feigelson
发明人： Yang-I Lin , Panayota Bitha , Subas Sakya , Timothy W. Strohmeyer , Karen Bush , Carl Bernard Ziegler , Gregg Brian Feigelson
IPC分类号： A61K31/40 , A61K31/397 , A61K31/4015 , A61K31/403 , A61K31/42 , A61K31/425 , A61K31/44 , A61K31/495 , A61K31/535 , A61P31/00 , A61P31/04 , C07D307/18 , C07D333/34 , C07D333/48 , C07D477/00 , C07D477/04 , C07D477/06 , C07D477/12 , C07D477/14 , C07D477/20 , C07F9/6561 , C07H11/00 , C07H19/01 , A61K31/395
CPC分类号： C07D307/18 , C07D333/34 , C07D477/14 , C07F9/65611 , C07H11/00 , C07H19/01 , Y02P20/582
摘要： Carbapenem antibiotic compounds of the general formula: ##STR1## wherein the moiety ##STR2## is a 4, 5 or 6 membered mono, di- or tri- substituted oxygen or sulfur containing ring; wherein Z is oxygen, sulfur, sulfoxide and sulfone, pharmaceutical compositions thereof useful for the treatment of bacterial infections, method of inhibiting a Beta-lactamase enzyme by administering said compounds, processes for preparing the compounds and new intermediates useful in the process are disclosed.
摘要翻译： 具有以下通式的卡巴培南抗生素化合物：其中部分“IMAGE”是4,5或6元单，二或三取代的含氧或含硫环; 其中Z是氧，硫，亚砜和砜，可用于治疗细菌感染的药物组合物，通过施用所述化合物抑制β-内酰胺酶的方法，制备化合物的方法和用于该方法的新中间体。
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公开(公告)号：US4744532A
公开(公告)日：1988-05-17
申请号：US93100
申请日：1987-09-01
CPC分类号： G05D1/0077 , B64C13/503 , Y02T50/44
摘要： Flight control system for aircraft of the type provided with ailerons, elevators, upper surface spoilers, and upper surface air-brakes, a rudder and horizontal stabilizers with variable angle of incidence, said system comprising an electric control, in some cases without any mechanical emergency control for said upper surface spoilers and air-brakes.According to the invention:the ailerons and elevators are electrically controlled without any mechanical aid,the rudder is mechanically controlled, andthe horizontal stabilizers with variable angle of incidence are electrically controlled with mechanical aid.the electrical flight controls are optimized.
摘要翻译： 具有副翼，电梯，上表面扰流板和上表面空气制动器的类型飞机的飞行控制系统，具有可变入射角的舵和水平稳定器，所述系统包括电气控制，在某些情况下没有任何机械紧急 控制所述上表面扰流板和空气制动器。 根据本发明：副翼和电梯在没有任何机械辅助的情况下被电控制，方向舵被机械地控制，并且具有可变入射角的水平稳定器通过机械辅助被电控制。 电气飞行控制优化。
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公开(公告)号：US20120328360A1
公开(公告)日：2012-12-27
申请号：US13576727
申请日：2010-12-09
CPC分类号： B23K11/14 , B21J15/08 , B23K9/207 , B23K11/0066 , B23K35/0288 , B23K2101/006 , Y10T29/49776 , Y10T29/49865 , Y10T29/49943 , Y10T29/49956 , Y10T403/471
摘要： A method for non-releasable fixing of at least one component to a further component is provided in which a hot rivet is introduced into an opening of the at least one first component and an end face of a shank of the hot rivet is welded to a surface of the further component. Subsequently, with plastic deformation of the hot rivet, the shank of the hot rivet is compressed until a head of the hot rivet lies with a pre-stressing force at least in areas on a surface of the at least one component. The pre-stressing force, with which the head of the hot rivet lies at least in areas on the surface of the at least one component, is adjusted to a predefined value.
摘要翻译： 提供了一种用于将至少一个部件不可释放地固定到另一部件的方法，其中将热铆钉引入所述至少一个第一部件的开口中，并且所述热铆钉的柄的端面焊接到 表面的另一个组件。 随后，随着热铆钉的塑性变形，热铆钉的柄被压缩直到热铆钉的头部至少在至少一个部件的表面上的区域中具有预应力。 热铆钉的头部至少位于至少一个部件的表面上的区域中的预加压力被调整到预定值。
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公开(公告)号：US20110086086A1
公开(公告)日：2011-04-14
申请号：US11574045
申请日：2006-06-13
IPC分类号： A61K9/70 , C07D471/08 , A61K31/4985 , A61P25/34
CPC分类号： A61K31/4995 , A61K9/0014 , A61K9/12 , A61K9/7061 , A61K9/7084
摘要： The invention provides transdermal compositions comprising varenicline or its pharmaceutically acceptable salt or prodrug form.
摘要翻译： 本发明提供了包含伐尼克林或其药学上可接受的盐或前药形式的透皮组合物。
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公开(公告)号：US20080269314A1
公开(公告)日：2008-10-30
申请号：US11666707
申请日：2005-10-12
申请人： Antone John Debetten-Court , Peter Robert Rose , Evgenyi Yur'evich Shalaev , George Joseph Quallich , Carl Bernard Ziegler
发明人： Antone John Debetten-Court , Peter Robert Rose , Evgenyi Yur'evich Shalaev , George Joseph Quallich , Carl Bernard Ziegler
IPC分类号： A61K31/40
CPC分类号： C07D207/34 , A61K9/145 , A61K9/146 , A61K9/19 , A61K31/40
摘要： A process for forming amorphous atorvastatin comprising the steps of dissolving atorvastatin in a non-hydroxylic solvent and removing the solvent by freeze-drying, as well as processes of dissolving atorvastatin in a hydroxylic solvent with a solubilizing agent or an alkalizing agent or an antioxidant and removing the solvent by freeze-drying to afford amorphous atorvastatin.
摘要翻译： 一种形成无定形阿托伐他汀的方法，包括以下步骤：将阿托伐他汀溶解在非羟基溶剂中并通过冷冻干燥除去溶剂，以及将阿托伐他汀溶解在羟基溶剂中与增溶剂或碱化剂或抗氧化剂，以及 通过冷冻干燥除去溶剂，得到无定形的阿托伐他汀。
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公开(公告)号：US20080181933A1
公开(公告)日：2008-07-31
申请号：US11816731
申请日：2006-03-09
IPC分类号： A61K9/68 , A23G4/06 , A23G4/18 , A61K31/4985 , A23G4/20
CPC分类号： A61K9/0058 , A61K31/55
摘要： A chewing gum composition including a water insoluble base portion; a water soluble portion; and a therapeutically effective amount of varenicline or its pharmaceutical acceptable salt thereof. A method for reducing nicotine addiction and aiding in the cessation or lessening of tobacco use in an individual by administering to an oral cavity of an individual a chewing gum composition including an effective amount of varenicline or its pharmaceutical acceptable salt thereof; and chewing the gum composition to cause the varenicline or its pharmaceutical acceptable salt thereof to be released from the chewing gum composition into the oral cavity of the individual. A method of manufacturing a chewing gum composition.
摘要翻译： 一种口香糖组合物，其包含水不溶性基部分; 水溶性部分; 以及治疗有效量的伐尼克林或其药学上可接受的盐。 一种通过向个体口腔施用包含有效量的伐伦克林或其药学上可接受的盐的口香糖组合物来减少尼古丁成瘾和帮助停止或减轻个体中烟草使用的方法; 并咀嚼所述口香糖组合物以使所述伐伦克林或其药学上可接受的盐从口香糖组合物释放到个体的口腔中。 一种口香糖组合物的制造方法。
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