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1.
公开(公告)号:US10449026B2
公开(公告)日:2019-10-22
申请号:US13928338
申请日:2013-06-26
申请人: Biostage, Inc.
发明人: Ron Sostek , David Green , Linghui Meng , Sherif Soliman , Joseph Consiglio
IPC分类号: A61F2/06 , A61F2/00 , A61L33/00 , A61F2/04 , A61F2/07 , D04H1/4382 , D01D5/00 , A61L27/34 , A61F2/02
摘要: Aspects of the disclosure relate to synthetic tissue or organ scaffolds and methods and compositions for promoting or maintaining their structural integrity. Aspects of the disclosure are useful to prevent scaffold damage (e.g., delamination) during or after implantation into a host. Aspects of the disclosure are useful to stabilize tissue or organ scaffolds that include electrospun fibers.
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公开(公告)号:US12029638B2
公开(公告)日:2024-07-09
申请号:US17589096
申请日:2022-01-31
申请人: Biostage, Inc.
发明人: Saverio La Francesca , Sherif Soliman , Matthew Marsh , Shunfu Hu , Linghui Meng
IPC分类号: A61F2/04 , A61F2/00 , A61F2/07 , A61F2/82 , A61L27/04 , A61L27/18 , A61L27/38 , A61L27/56 , A61L27/58 , C12M1/12 , C12M3/00 , A61F2/90
CPC分类号: A61F2/04 , A61F2/0077 , A61F2/07 , A61F2/82 , A61L27/04 , A61L27/18 , A61L27/3834 , A61L27/56 , A61L27/58 , C12M21/08 , C12M25/14 , A61F2002/0086 , A61F2002/043 , A61F2002/044 , A61F2002/045 , A61F2002/046 , A61F2/90 , A61F2210/0004 , A61F2210/0076 , A61F2230/0069 , A61F2250/0067 , A61L2430/22 , A61L27/18 , C08L75/04 , A61L27/18 , C08L67/02
摘要: Aspects of the disclosure relate methods and synthetic scaffolds for regenerating gastrointestinal tissue (e.g., esophageal tissue).
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公开(公告)号:US11234805B2
公开(公告)日:2022-02-01
申请号:US16391212
申请日:2019-04-22
申请人: Biostage, Inc.
发明人: Saverio La Francesca , Sherif Soliman , Matthew Marsh , Shunfu Hu , Linghui Meng
IPC分类号: A61F2/04 , A61F2/07 , C12M3/00 , C12M1/12 , A61F2/00 , A61L27/04 , A61L27/18 , A61L27/38 , A61L27/56 , A61F2/82 , A61L27/58 , A61F2/90
摘要: Aspects of the disclosure relate methods and synthetic scaffolds for regenerating gastrointestinal tissue (e.g., esophageal tissue).
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公开(公告)号:US10265153B2
公开(公告)日:2019-04-23
申请号:US15350970
申请日:2016-11-14
申请人: Biostage, Inc.
IPC分类号: A61F2/04 , A61F2/07 , A61F2/00 , A61L27/04 , A61L27/18 , A61L27/38 , A61L27/56 , A61F2/82 , A61L27/58 , C12M3/00 , C12M1/12 , A61F2/90
摘要: Aspects of the disclosure relate methods and synthetic scaffolds for regenerating gastrointestinal tissue (e.g., esophageal tissue).
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5.
公开(公告)号:US20170319325A1
公开(公告)日:2017-11-09
申请号:US15351295
申请日:2016-11-14
申请人: Biostage, Inc.
CPC分类号: A61F2/04 , A61F2/0077 , A61F2/07 , A61F2/82 , A61F2/90 , A61F2002/0086 , A61F2002/043 , A61F2002/044 , A61F2002/045 , A61F2002/046 , A61F2210/0004 , A61F2210/0076 , A61F2230/0069 , A61F2250/0067 , A61L27/04 , A61L27/18 , A61L27/3834 , A61L27/56 , A61L27/58 , A61L2430/22 , C12M21/08 , C12M25/14 , C08L75/04 , C08L67/02
摘要: Aspects of the disclosure relate methods and synthetic scaffolds for regenerating gastrointestinal tissue (e.g., esophageal tissue).
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公开(公告)号:US12121629B2
公开(公告)日:2024-10-22
申请号:US17688676
申请日:2022-03-07
申请人: Biostage, Inc.
发明人: William Fodor , Linghui Meng , Sherif Soliman , Shunfu Hu
CPC分类号: A61L27/26 , A61L27/34 , A61L27/3679 , A61L27/3691 , A61L27/3695 , A61L27/3834 , A61L27/3882 , A61L27/56 , A61L2300/412 , A61L2420/06 , A61L2430/34
摘要: Aspects of the disclosure relate methods and synthetic scaffolds for regenerating hollow tubular organs present in the respiratory system such as bronchus tissue.
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公开(公告)号:US11284987B2
公开(公告)日:2022-03-29
申请号:US14760014
申请日:2014-01-09
申请人: Biostage, Inc.
发明人: Ron Sostek
摘要: Aspects of the invention relate to a combination of techniques and/or materials that can be used to form a synthetic scaffold for solid and/or hollow organs or tissue. In some embodiments, methods are provided that involve assembling a synthetic scaffold using a first material for a first structural component and a second material for a second structural component, in which the first or second structural component is a perfusion pathway. In some embodiments, materials (e.g., synthetic materials) for the scaffold are printed, molded, cast, polymerized, or electrospun. In some embodiments, a scaffold may mimic a natural scaffold or several features of a natural scaffold.
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8.
公开(公告)号:US20200085557A1
公开(公告)日:2020-03-19
申请号:US16565189
申请日:2019-09-09
申请人: Biostage, Inc.
发明人: Ron Sostek , David Green , Linghui Meng , Sherif Soliman , Joseph Consiglio
摘要: Aspects of the disclosure relate to synthetic tissue or organ scaffolds and methods and compositions for promoting or maintaining their structural integrity. Aspects of the disclosure are useful to prevent scaffold damage (e.g., delamination) during or after implantation into a host. Aspects of the disclosure are useful to stabilize tissue or organ scaffolds that include electrospun fibers.
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公开(公告)号:US20200056134A1
公开(公告)日:2020-02-20
申请号:US16663899
申请日:2019-10-25
申请人: Biostage, Inc.
发明人: Herbert Hedberg
摘要: Aspects of the disclosure relate to rotating bioreactors and articles and methods that are useful for adapting a rotating bioreactor for use with tissues or scaffolds of different sizes. In some embodiments, bioreactors comprising a reservoir and an arbor assembly are provided herein, in which the arbor assembly comprises a rotatable support to which a tissue or tissue scaffold can be attached.
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公开(公告)号:US20190029796A1
公开(公告)日:2019-01-31
申请号:US16020053
申请日:2018-06-27
申请人: Biostage, Inc.
IPC分类号: A61F2/04 , C12M1/12 , A61F2/00 , C12M3/00 , A61F2/82 , A61L27/04 , A61L27/18 , A61L27/38 , A61L27/56 , A61L27/58 , A61F2/90
摘要: Aspects of the disclosure relate methods and synthetic scaffolds for regenerating gastrointestinal tissue (e.g., esophageal tissue).
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