摘要:
The present invention relates to a compound inhibiting HF-1 activity, a preparation method of the same, and a pharmaceutical composition comprising the same as an active ingredient. The compound of the present invention demonstrates anticancer activity not by non-selective cytotoxicity but by inhibiting the activity of HIF-1, the transcription factor playing an important role in cancer cell growth and metastasis.Accordingly, the compound or the pharmaceutically acceptable salt thereof according to the present invention inhibits HIF-1 activity, and therefore can be used as a therapeutic agent for solid tumors such as colon cancer, liver cancer, stomach cancer and breast cancer. In addition, the compound or the pharmaceutically acceptable salt thereof according to the present invention can be used as an active ingredient for a therapeutic agent for diabetic retinopathy or arthritis which may become worse when hypoxia-induced VEGF expression by HIF-1 increases.
摘要:
N-hydroxy-4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy}benzamidine 2 ethansulfonic acid salt, a process for the preparation thereof, a pharmaceutical composition for preventing and treating osteoporosis, bone fractures or allergic inflammatory diseases, comprising the same, and an oral formulation for preventing and treating osteoporosis, bone fractures or allergic inflammatory diseases, comprising the same are described.
摘要:
Example embodiments relate to a pixel structure of a CMOS image sensor, and associated methods. The pixel structure may include a substrate of a first-conductivity, a photodiode region of a second conductivity in the first-conductivity substrate, and a capacitor electrode on the second-conductivity photodiode region.
摘要:
A method and apparatus for confirming a location of a lost wireless terminal is provided. A location confirmation request of the lost wireless terminal is received by a mobile communication network and identification information of the lost wireless terminal is transmitted to wireless terminals which have joined a location confirmation service of the lost wireless terminal. The wireless terminal which has joined the service searches for a wireless terminal corresponding to identification information coinciding with the identification information of the lost wireless terminal. The wireless terminal which has joined the service transmits a location of the previously searched for lost wireless terminal to the mobile communication network. The mobile communication network manages the received location of the lost wireless terminal.
摘要:
The present invention relates to a compound inhibiting HF-1 activity, a preparation method of the same, and a pharmaceutical composition comprising the same as an active ingredient. The compound of the present invention demonstrates anticancer activity not by non-selective cytotoxicity but by inhibiting the activity of HIF-1, the transcription factor playing an important role in cancer cell growth and metastasis. Accordingly, the compound or the pharmaceutically acceptable salt thereof according to the present invention inhibits HIF-1 activity, and therefore can be used as a therapeutic agent for solid tumors such as colon cancer, liver cancer, stomach cancer and breast cancer. In addition, the compound or the pharmaceutically acceptable salt thereof according to the present invention can be used as an active ingredient for a therapeutic agent for diabetic retinopathy or arthritis which may become worse when hypoxia-induced VEGF expression by HIF-1 increases.
摘要:
The present invention relates to a compound inhibiting HF-1 activity, a preparation method of the same, and a pharmaceutical composition comprising the same as an active ingredient. The compound of the present invention demonstrates anticancer activity not by non-selective cytotoxicity but by inhibiting the activity of HIF-1, the transcription factor playing an important role in cancer cell growth and metastasis. Accordingly, the compound or the pharmaceutically acceptable salt thereof according to the present invention inhibits HIF-1 activity, and therefore can be used as a therapeutic agent for solid tumors such as colon cancer, liver cancer, stomach cancer and breast cancer. In addition, the compound or the pharmaceutically acceptable salt thereof according to the present invention can be used as an active ingredient for a therapeutic agent for diabetic retinopathy or arthritis which may become worse when hypoxia-induced VEGF expression by HIF-1 increases.
摘要:
The present invention relates to novel benzamidine derivatives, a process for the preparation thereof and a pharmaceutical composition for preventing or treating osteoporosis comprising the same. The benzamidine derivatives of the present invention effectively inhibit osteoclast differentiation at an extremely low concentration, and thus can be advantageously used for the prevention and treatment of osteoporosis.
摘要:
An apparatus and method for re-transmitting erroneous packet data is disclosed. Each of the physical layers of the system includes a buffer, a timer, a controller, and a radio frequency unit. The buffer temporarily stores transmitted data in the form of a final data frame capable of being transmitted on a transmission line without any processing. The timer is a time counter adapted to limit the time, for which the transmission end waits for an acknowledgment to a transmission of data after the data transmission is made. If no acknowledgment signal is received when the timer expires the buffered data in the physical layer is re-transmitted. This reduces the data transmission delay resulting from the inter-layer movement of data generated during a re-transmission of erroneous data, and the transmission delay of packet data resulting from overhead time.
摘要:
N-hydroxy-4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy} benzamidine 2 ethansulfonic acid salt, a process for the preparation thereof, a pharmaceutical composition for preventing and treating osteoporosis, bone fractures or allergic inflammatory diseases, comprising the same, and an oral formulation for preventing and treating osteoporosis, bone fractures or allergic inflammatory diseases, comprising the same are described.
摘要:
An image processing device, method, and medium providing an optimal video signal to users when a video signal is output after predetermined data is overlaid over the video signal. The image processing device includes a separating unit that separates a video signal, an audio signal, and additional information from a broadcast signal, a memory unit that stores a partial video signal corresponding to a predetermined area of an original video signal, the partial video signal obtained by decoding the separated video signal, and a control unit that overlays the separated additional information over the stored partial video signal and outputs a final video signal obtained by overlaying the partial video signal over which the separated additional information is overlaid over the original video signal.