-
公开(公告)号：US20100184989A1
公开(公告)日：2010-07-22
申请号：US12530438
申请日：2008-03-12
申请人： Jennifer Riggs-Sauthier , Bo-Liang Deng , Zhongxu Ren , Wen Zhang , Xuyuan Gu , Franco J. Duarte
发明人： Jennifer Riggs-Sauthier , Bo-Liang Deng , Zhongxu Ren , Wen Zhang , Xuyuan Gu , Franco J. Duarte
IPC分类号： A61K47/48
CPC分类号： C08G65/3315 , A61K47/60 , C08G65/33306 , C08G65/33337 , C08G65/33368 , C08G65/33389 , C08L2203/02
摘要： The invention provides methods for the preparation of small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer obtained from a water-soluble oligomer composition. Such drugs are produced through modification of a synthetic pathway to attach the oligomer to an intermediate compound followed by completion of the synthetic path.
摘要翻译： 本发明提供了通过共价连接由水溶性低聚物组合物获得的水溶性低聚物进行化学修饰的小分子药物的制备方法。 通过修饰合成途径产生这样的药物，以将低聚物连接到中间体化合物，然后完成合成路径。
-
公开(公告)号：US20110269677A1
公开(公告)日：2011-11-03
申请号：US12530363
申请日：2008-03-12
申请人： Jennifer Riggs-Sauthier , Lin Cheng , Tacey X. Viegas , Xuyuan Gu , Franco J. Duarte , Wen Zhang
发明人： Jennifer Riggs-Sauthier , Lin Cheng , Tacey X. Viegas , Xuyuan Gu , Franco J. Duarte , Wen Zhang
IPC分类号： A61K38/05 , C07D213/56 , C07F9/655 , C07D401/06 , C07D239/10 , C07D401/12 , C07D217/26 , C07D417/12 , C07D405/12 , C07D493/04 , A61K31/635 , A61K31/4418 , A61K31/665 , A61K31/496 , A61K31/513 , A61K31/472 , A61K31/427 , A61K31/4433 , A61P31/18 , C07D307/20
CPC分类号： A61K47/48215 , A61K47/60
摘要： The invention provides protease inhibitors that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the protease inhibitors not attached to the water-soluble oligomer.
摘要翻译： 本发明提供通过共价连接水溶性低聚物进行化学修饰的蛋白酶抑制剂。 本发明的缀合物当通过多种施用途径中的任一种施用时，显示出与未附着于水溶性低聚物的蛋白酶抑制剂不同的特征。
-
公开(公告)号：US08598364B2
公开(公告)日：2013-12-03
申请号：US12530363
申请日：2008-03-12
申请人： Jennifer Riggs-Sauthier , Lin Cheng , Tacey X. Viegas , Xuyuan Gu , Franco J. Duarte , Wen Zhang
发明人： Jennifer Riggs-Sauthier , Lin Cheng , Tacey X. Viegas , Xuyuan Gu , Franco J. Duarte , Wen Zhang
IPC分类号： C07D239/02 , C07D401/00 , C07D217/00 , C07D405/00 , C07D213/00 , C07D277/30 , C07D493/00 , C07D307/02 , C07F9/28 , C07F9/06
CPC分类号： A61K47/48215 , A61K47/60
摘要： The invention provides protease inhibitors that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the protease inhibitors not attached to the water-soluble oligomer.
摘要翻译： 本发明提供通过共价连接水溶性低聚物进行化学修饰的蛋白酶抑制剂。 本发明的缀合物当通过多种施用途径中的任一种施用时，显示出与未附着于水溶性低聚物的蛋白酶抑制剂不同的特征。
-
公开(公告)号：US20110098273A1
公开(公告)日：2011-04-28
申请号：US12674139
申请日：2008-09-03
IPC分类号： A61K31/554 , C07D213/80 , A61K31/4418 , C07D417/02 , A61K31/4439 , C07D413/02 , C07C255/00 , A61K31/135 , C07D281/02 , A61P43/00
CPC分类号： A61K31/4422 , A61K31/4418 , A61K47/48215 , A61K47/60 , C07C255/43 , C07D211/90 , C07D281/10 , C07D413/04 , C07D417/04
摘要： The invention provides small molecule drugs that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the small molecule drug not attached to the water soluble oligomer.
摘要翻译： 本发明提供通过共价连接水溶性低聚物进行化学修饰的小分子药物。 本发明的缀合物当通过多种施用途径中的任一种施用时，显示出与未附着于水溶性低聚物的小分子药物的特征不同的特征。
-
公开(公告)号：US08748648B2
公开(公告)日：2014-06-10
申请号：US12674139
申请日：2008-09-03
IPC分类号： C07C255/00
CPC分类号： A61K31/4422 , A61K31/4418 , A61K47/48215 , A61K47/60 , C07C255/43 , C07D211/90 , C07D281/10 , C07D413/04 , C07D417/04
摘要： The invention provides small molecule drugs that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the small molecule drug not attached to the water soluble oligomer.
摘要翻译： 本发明提供通过共价连接水溶性低聚物进行化学修饰的小分子药物。 本发明的缀合物当通过多种施用途径中的任一种施用时，显示出与未附着于水溶性低聚物的小分子药物的特征不同的特征。
-
公开(公告)号：US20100298296A1
公开(公告)日：2010-11-25
申请号：US12744467
申请日：2008-11-28
IPC分类号： A61K31/55 , C07D223/24 , C07C211/32 , A61K31/137 , C07D313/12 , A61K31/335 , A61P29/00
CPC分类号： C07D313/12 , A61K47/60 , C07C217/48
摘要： The invention provides small molecule drugs that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the small molecule drug not attached to the water soluble oligomer.
摘要翻译： 本发明提供通过共价连接水溶性低聚物进行化学修饰的小分子药物。 本发明的缀合物当通过多种施用途径中的任一种施用时，显示出与未附着于水溶性低聚物的小分子药物的特征不同的特征。
-
公开(公告)号：US08569380B2
公开(公告)日：2013-10-29
申请号：US12744467
申请日：2008-11-28
IPC分类号： A61K31/13 , C07C211/00
CPC分类号： C07D313/12 , A61K47/60 , C07C217/48
摘要： The invention provides small molecule drugs that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the small molecule drug not attached to the water soluble oligomer.
摘要翻译： 本发明提供通过共价连接水溶性低聚物进行化学修饰的小分子药物。 本发明的缀合物当通过多种施用途径中的任一种施用时，显示出与未附着于水溶性低聚物的小分子药物的特征不同的特征。
-
公开(公告)号：US20140371258A1
公开(公告)日：2014-12-18
申请号：US13995063
申请日：2011-12-16
IPC分类号： A61K47/48 , A61K31/4745
CPC分类号： A61K31/4745 , A61K47/60
摘要： Provided herein are water-soluble polymer conjugates of topotecan, along with compositions comprising the conjugates and related methods of making and using the same.
摘要翻译： 本文提供拓扑替康的水溶性聚合物共轭物，以及包含共轭物的组合物及其制备和使用它们的相关方法。
-
公开(公告)号：US08440687B2
公开(公告)日：2013-05-14
申请号：US13426521
申请日：2012-03-21
IPC分类号： A61K31/485 , C07D489/08
CPC分类号： A61K31/485 , A61K31/402 , A61K31/4025 , A61K31/439 , A61K31/4468 , A61K47/10 , A61K47/60 , C07D489/02
摘要： The invention provides compounds that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from those of the compound not attached to the water-soluble oligomer.
-
公开(公告)号：US08389759B2
公开(公告)日：2013-03-05
申请号：US12530424
申请日：2008-03-12
CPC分类号： C07C69/736 , A61K47/60
摘要： The invention provides anticholinergic agents that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different as compared to the characteristics of the anticholinergic agent not attached to the water-soluble oligomer.
摘要翻译： 本发明提供通过共价连接水溶性低聚物进行化学修饰的抗胆碱能药。 本发明的缀合物当通过多种施用途径中的任一种施用时，显示出与未附着于水溶性低聚物的抗胆碱能药物的特征相比不同的特征。
-
-
-
-
-
-
-
-
-
搜索结果
79 条记录 (耗时 0.054 秒)
