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    Compositions and methods for inhibiting proteases
    3.
    发明授权
    Compositions and methods for inhibiting proteases 有权
    抑制蛋白酶的组合物和方法

    公开(公告)号：US09409944B2

    公开(公告)日：2016-08-09

    申请号：US14131681

    申请日：2012-07-12

    申请人： William H. Gerwick ,  Alban R. Pereira-Badilla ,  Tara Byrum ,  Frederick A. Valeriote ,  Michael Kenneth Gilson ,  Andrew T. Fenley ,  Bradley S. Moore ,  Andrew Kale ,  Hosana Debonsi

    发明人： William H. Gerwick ,  Alban R. Pereira-Badilla ,  Tara Byrum ,  Frederick A. Valeriote ,  Michael Kenneth Gilson ,  Andrew T. Fenley ,  Bradley S. Moore ,  Andrew Kale ,  Hosana Debonsi

    IPC分类号： C07K5/083 ,  A61K31/336 ,  C07K5/062

    CPC分类号： C07K5/0808 ,  A61K31/336 ,  C07K5/06052

    摘要： In particular, in alternative embodiments, the invention provides pharmaceutical compounds and formulations comprising a family of epoxyketone compounds, which include racemic mixtures or racemates, isomers, stereoisomers, diastereoisomers, derivatives and analogs, and methods for making and using them. In alternative embodiments, pharmaceutical compositions and formulations of the invention are administered to an individual in need thereof in an amount sufficient to treat, prevent, reverse and/or ameliorate an infection, disease or condition that can be ameliorated, treated, prevented or reversed by partially or completely inhibiting a chymotrypsin-like protease or a proteasome activity, including e.g., a retroviral infection such as human immunodeficiency virus-1 (HIV-1) infection, an immune disorder, a neurodegenerative disease or condition, or a cancer such as a myeloma or multiple myeloma, an adenocarcinoma such as a lung adenocarcinoma, a pancreatic cancer, a B-cell related cancer, and lymphomas such as non-Hodgkin's lymphoma.

    摘要翻译： 特别地，在替代实施方案中，本发明提供包含一系列环氧酮化合物的药物化合物和制剂，其包括外消旋混合物或外消旋体，异构体，立体异构体，非对映异构体，衍生物和类似物，以及制备和使用它们的方法。 在替代实施方案中，将本发明的药物组合物和制剂以足以治疗，预防，逆转和/或改善可被改善，治疗，预防或逆转的感染，疾病或病症的量施用于有需要的个体 部分或完全抑制胰凝乳蛋白酶样蛋白酶或蛋白酶体活性，包括例如逆转录病毒感染如人免疫缺陷病毒-1（HIV-1）感染，免疫疾病，神经变性疾病或病症，或癌症如 骨髓瘤或多发性骨髓瘤，腺癌如肺腺癌，胰腺癌，B细胞相关癌症，淋巴瘤如非霍奇金淋巴瘤。

    COMPOSITIONS AND METHODS FOR INHIBITING PROTEASES
    4.
    发明申请
    COMPOSITIONS AND METHODS FOR INHIBITING PROTEASES 有权
    用于抑制蛋白质的组合物和方法

    公开(公告)号：US20140248333A1

    公开(公告)日：2014-09-04

    申请号：US14131681

    申请日：2012-07-12

    申请人： William H. Gerwick ,  Alban R. Pereira-Badilla ,  Tara Byrum ,  Frederick A. Valeriote ,  Michael Kenneth Gilson ,  Andrew Fenley ,  Bradley S. Moore ,  Andrew Kale ,  Hosana M. Debonsi

    发明人： William H. Gerwick ,  Alban R. Pereira-Badilla ,  Tara Byrum ,  Frederick A. Valeriote ,  Michael Kenneth Gilson ,  Andrew Fenley ,  Bradley S. Moore ,  Andrew Kale ,  Hosana M. Debonsi

    IPC分类号： C07K5/083

    CPC分类号： C07K5/0808 ,  A61K31/336 ,  C07K5/06052

    摘要： In particular, in alternative embodiments, the invention provides pharmaceutical compounds and formulations comprising a family of epoxyketone compounds, which include racemic mixtures or racemates, isomers, stereoisomers, diastereoisomers, derivatives and analogs, and methods for making and using them. In alternative embodiments, pharmaceutical compositions and formulations of the invention are administered to an individual in need thereof in an amount sufficient to treat, prevent, reverse and/or ameliorate an infection, disease or condition that can be ameliorated, treated, prevented or reversed by partially or completely inhibiting a chymotrypsin-like protease or a proteasome activity, including e.g., a retroviral infection such as human immunodeficiency virus-1 (HIV-1) infection, an immune disorder, a neurodegenerative disease or condition, or a cancer such as a myeloma or multiple myeloma, an adenocarcinoma such as a lung adenocarcinoma, a pancreatic cancer, a B-cell related cancer, and lymphomas such as non-Hodgkin's lymphoma.

    摘要翻译： 特别地，在替代实施方案中，本发明提供包含一系列环氧酮化合物的药物化合物和制剂，其包括外消旋混合物或外消旋体，异构体，立体异构体，非对映异构体，衍生物和类似物，以及制备和使用它们的方法。 在替代实施方案中，将本发明的药物组合物和制剂以足以治疗，预防，逆转和/或改善可被改善，治疗，预防或逆转的感染，疾病或病症的量施用于有需要的个体 部分或完全抑制胰凝乳蛋白酶样蛋白酶或蛋白酶体活性，包括例如逆转录病毒感染如人免疫缺陷病毒-1（HIV-1）感染，免疫疾病，神经变性疾病或病症，或癌症如 骨髓瘤或多发性骨髓瘤，腺癌如肺腺癌，胰腺癌，B细胞相关癌症，淋巴瘤如非霍奇金淋巴瘤。

    Method for removal of cured films from cookware and bakeware products
    5.
    发明授权
    Method for removal of cured films from cookware and bakeware products 失效
    从炊具和烤盘产品中去除固化膜的方法

    公开(公告)号：US06491762B1

    公开(公告)日：2002-12-10

    申请号：US09635382

    申请日：2000-08-09

    申请人： Gilbert L. Bundy ,  Bradley S. Moore

    发明人： Gilbert L. Bundy ,  Bradley S. Moore

    IPC分类号： B08B102

    CPC分类号： B08B3/02

    摘要： A method for removing non-stick coatings from cookware or bakeware products is disclosed. The method includes the step of determining the angles of the primary surfaces of a pan having a coating to be removed. The method further includes the step of configuring a high-speed, multiport, rotating cleaning head to provide at least one water jet associated with each primary surface. The method further includes the step of employing the cleaning head to deliver an ultra-high pressure water jet directed at the pan while tracking the cleaning head along a plane substantially parallel to the upper surface of the pan. Using the method of the present invention, a coating may be removed from a pan in a single pass.

    摘要翻译： 公开了一种从炊具或烤盘产品中去除不粘涂层的方法。 该方法包括确定具有待除去涂层的盘的主表面的角度的步骤。 该方法还包括配置高速多端口旋转清洁头以提供与每个主表面相关联的至少一个水射流的步骤。 该方法还包括采用清洁头在沿着基本上平行于锅的上表面的平面跟踪清洁头的同时传送指向锅的超高压水射流的步骤。 使用本发明的方法，可以在一次通过中从锅中去除涂层。