公开(公告)号：US20050053596A1

公开(公告)日：2005-03-10

申请号：US10492058

申请日：2002-10-09

Applicant: Bradley Stringer

Inventor： Bradley Stringer

IPC: A61K9/19 ,  A61K9/20 ,  A61K35/32 ,  A61K38/18 ,  A61K38/48

CPC classification number: A61K9/19 ,  A61K9/2095 ,  A61K35/32 ,  A61K38/1875 ,  A61K2300/00

Abstract: An extracellular material in freeze-dried form obtained from skeletal cells which has osseoinductive bone repair and regeneration activity in vivo, and compositions and methods involving the material.

Abstract translation: 从骨骼细胞获得的冷冻干燥形式的细胞外物质，其具有骨诱导性骨修复和体内再生活性，以及​​涉及该材料的组合物和方法。

公开(公告)号：US20050020919A1

公开(公告)日：2005-01-27

申请号：US10911860

申请日：2004-08-03

Applicant: Bradley Stringer ,  Gary Simmons ,  Douglas Christensen ,  Shayne Messerly ,  Cameron Ford ,  Robert Evensen

Inventor： Bradley Stringer ,  Gary Simmons ,  Douglas Christensen ,  Shayne Messerly ,  Cameron Ford ,  Robert Evensen

IPC: A61B8/06 ,  A61B8/08 ,  A61B8/00

CPC classification number: A61B8/0841 ,  A61B5/489 ,  A61B8/06 ,  A61B8/0833 ,  A61B8/13 ,  A61B8/145 ,  A61B8/42 ,  A61B8/4227 ,  A61B8/4455

Abstract: An apparatus, method and system for cannulation of blood vessels. The apparatus comprises a sensor assembly including two linear transducer arrays oriented perpendicular to each other to form a “T” shape to provide ultrasound images of at least one blood vessel in a portion of a patient's body in two perpendicular planes and optionally determine flow direction within the at least one blood vessel. The sensor assembly may be disposed within a graphically marked cover to facilitate orientation of the sensor assembly on the patient and guidance of a needle towards a desired target vessel during the cannulation procedure. The cover may also include associated structure to cooperate with a reference location element to place, align and secure the sensor assembly to the patient's skin at a desired location.

Abstract translation: 用于插管血管的装置，方法和系统。 该装置包括传感器组件，其包括彼此垂直定向以形成“T”形状的两个线性换能器阵列，以在两个垂直平面中的患者身体的一部分中提供至少一个血管的超声图像，并且可选地确定 所述至少一个血管。 传感器组件可以设置在图形标记的盖内，以便于在插管过程期间传感器组件在患者身上的取向和针朝向期望的目标血管的引导。 盖还可以包括相关联的结构，以与参考位置元件配合，以将传感器组件放置，对准并将其固定到患者的皮肤上的所需位置。

公开(公告)号：US20050129673A1

公开(公告)日：2005-06-16

申请号：US11001658

申请日：2004-12-01

Applicant: Bradley Stringer

Inventor： Bradley Stringer

IPC: A61K35/12 ,  A61K48/00 ,  C12N5/077 ,  C12N15/85 ,  C12N5/08

CPC classification number: C12N5/0655 ,  A61K35/12 ,  C12N2503/04 ,  C12N2510/04

Abstract: The invention relates to chondrocytes and chondrocyte cell-lines for use especially in studying arthritic conditions and also for developing skeletal tissue for use in repair and/or replacement surgery. The use of articular chondrocyte cell-lines which mineralise calcium to determine potentially beneficial therapeutic agents is disclosed. Further, the means for producing such cell-lines is also disclosed as well as the characteristics of such cell-lines. The use of hypertrophic chondrocyte cell-lines to produce matrix tissue is also disclosed. Further means of producing hypertrophic chondrocyte cell-lines is also disclosed as well as the characteristics of such cell-lines.

Abstract translation: 本发明涉及软骨细胞和软骨细胞细胞系，其特别用于研究关节炎病症以及用于发展用于修复和/或替换手术的骨骼组织。 公开了使钙矿化钙决定潜在有益治疗剂的关节软骨细胞系的用途。 此外，还公开了这种细胞系的制造方法以及这种细胞系的特征。 还公开了肥大软骨细胞细胞系用于产生基质组织的用途。 还公开了生产肥大软骨细胞细胞系的进一步手段以及这些细胞系的特征。

公开(公告)号：US20070016030A1

公开(公告)日：2007-01-18

申请号：US11364811

申请日：2006-02-28

Applicant: Bradley Stringer

Inventor： Bradley Stringer

IPC: A61B8/00

CPC classification number: A61B8/0833 ,  A61B5/489 ,  A61B8/06 ,  A61B8/0841 ,  A61B8/13 ,  A61B8/145 ,  A61B8/42 ,  A61B8/4227 ,  A61B8/4455 ,  G01S7/5206 ,  G01S7/52071 ,  G01S7/5208 ,  G01S15/8913 ,  G01S15/8925 ,  G01S15/8979

Abstract: An apparatus is provided for cannulation of blood vessels. The apparatus comprises a sensor assembly including two linear transducer arrays oriented perpendicular to each other to form a “T” shape to provide ultrasound images of at least one blood vessel in a portion of a patient's body in two perpendicular planes. The sensor assembly includes a housing having a graphically marked surface to facilitate orientation of the sensor assembly on the patient and guidance of a needle towards a desired target vessel during the cannulation procedure. The housing is configured to engage a frame element having a pair of wings extending laterally therefrom, the wings each bearing a magnet to cooperate with a reference location element secured to a patient's skin and bearing magnetically responsive shims thereon to place, align and secure the sensor assembly to the patient's skin at a desired location.

Abstract translation: 提供了一种用于插管血管的装置。 该装置包括传感器组件，其包括彼此垂直定向以形成“T”形状的两个线性换能器阵列，以在两个垂直平面中的患者身体的一部分中提供至少一个血管的超声图像。 传感器组件包括具有图形标记的表面的壳体，以有助于传感器组件在患者身上的取向，并且在插管过程期间引导针朝向期望的目标血管。 壳体被构造成接合具有从其横向延伸的一对翼的框架元件，每个翼各自承载磁体，以与固定到患者皮肤上的参考位置元件配合，并且在其上承载磁性响应的垫片以放置，对准和固定传感器 在所需位置组装到患者的皮肤上。