公开(公告)号：US20130130930A1

公开(公告)日：2013-05-23

申请号：US13681274

申请日：2012-11-19

申请人： Bhairavi PARIKH ,  Michael D. BRODY ,  James STONE ,  Brian AWABDY ,  Urvi VED ,  Anh TRAN ,  Patrick J. COLLINS ,  David J. ANVAR

发明人： Bhairavi PARIKH ,  Michael D. BRODY ,  James STONE ,  Brian AWABDY ,  Urvi VED ,  Anh TRAN ,  Patrick J. COLLINS ,  David J. ANVAR

IPC分类号： C12Q1/68

CPC分类号： G01N33/5005 ,  C12Q1/68 ,  C12Q1/6806 ,  C12Q1/686 ,  C12Q1/6883 ,  G01N33/689

摘要： A method for concentrating and isolating nucleated cells, such as maternal and fetal nucleated red blood cells (nRBCs), in a maternal whole blood sample. The invention also provides methods and apparatus for preparing to analyze and analyzing the sample for identification of fetal genetic material as part of prenatal genetic testing. The invention also pertains to methods and apparatus for discriminating fetal nucleated red blood cells from maternal nucleated red blood cells obtained from a blood sample taken from a pregnant woman.

公开(公告)号：US20130130929A1

公开(公告)日：2013-05-23

申请号：US13681251

申请日：2012-11-19

申请人： Bhairavi PARIKH ,  Michael D. Brody ,  James Stone ,  Brian Awabdy ,  Urvi Ved ,  Anh Tran ,  Patrick J. Collins ,  David J. Anvar

发明人： Bhairavi PARIKH ,  Michael D. Brody ,  James Stone ,  Brian Awabdy ,  Urvi Ved ,  Anh Tran ,  Patrick J. Collins ,  David J. Anvar

IPC分类号： C12Q1/68

CPC分类号： G01N33/5005 ,  C12Q1/68 ,  C12Q1/6806 ,  C12Q1/686 ,  C12Q1/6883 ,  G01N33/689

摘要： A method for concentrating and isolating nucleated cells, such as maternal and fetal nucleated red blood cells (nRBCs), in a maternal whole blood sample. The invention also provides methods and apparatus for preparing to analyze and analyzing the sample for identification of fetal genetic material as part of prenatal genetic testing. The invention also pertains to methods and apparatus for discriminating fetal nucleated red blood cells from maternal nucleated red blood cells obtained from a blood sample taken from a pregnant woman.

摘要翻译： 在母体全血样品中浓缩和分离有核细胞如母体和胎儿有核红细胞（nRBC）的方法。 本发明还提供了用于分析和分析用于鉴定胎儿遗传物质的样品作为产前遗传测试的一部分的方法和装置。 本发明还涉及从从孕妇采集的血液样品获得的母体成核红细胞中区分胎儿有核红细胞的方法和装置。

公开(公告)号：US20130130265A1

公开(公告)日：2013-05-23

申请号：US13681296

申请日：2012-11-19

申请人： Bhairavi PARIKH ,  Michael D. BRODY ,  James STONE ,  Brian AWABDY ,  Urvi VED ,  Anh TRAN ,  David J. ANVAR

发明人： Bhairavi PARIKH ,  Michael D. BRODY ,  James STONE ,  Brian AWABDY ,  Urvi VED ,  Anh TRAN ,  David J. ANVAR

IPC分类号： C12Q1/68

CPC分类号： G01N33/5005 ,  C12Q1/68 ,  C12Q1/6806 ,  C12Q1/686 ,  C12Q1/6883 ,  G01N33/689

摘要： A method for concentrating and isolating nucleated cells, such as maternal and fetal nucleated red blood cells (nRBCs), in a maternal whole blood sample. The invention also provides methods and apparatus for preparing to analyze and analyzing the sample for identification of fetal genetic material as part of prenatal genetic testing. The invention also pertains to methods and apparatus for discriminating fetal nucleated red blood cells from maternal nucleated red blood cells obtained from a blood sample taken from a pregnant woman.

摘要翻译： 在母体全血样品中浓缩和分离有核细胞如母体和胎儿有核红细胞（nRBC）的方法。 本发明还提供了用于分析和分析用于鉴定胎儿遗传物质的样品作为产前遗传测试的一部分的方法和装置。 本发明还涉及从从孕妇采集的血液样品获得的母体成核红细胞中区分胎儿有核红细胞的方法和装置。