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公开(公告)号：US20130130265A1
公开(公告)日：2013-05-23
申请号：US13681296
申请日：2012-11-19
申请人： Bhairavi PARIKH , Michael D. BRODY , James STONE , Brian AWABDY , Urvi VED , Anh TRAN , David J. ANVAR
发明人： Bhairavi PARIKH , Michael D. BRODY , James STONE , Brian AWABDY , Urvi VED , Anh TRAN , David J. ANVAR
IPC分类号： C12Q1/68
CPC分类号： G01N33/5005 , C12Q1/68 , C12Q1/6806 , C12Q1/686 , C12Q1/6883 , G01N33/689
摘要： A method for concentrating and isolating nucleated cells, such as maternal and fetal nucleated red blood cells (nRBCs), in a maternal whole blood sample. The invention also provides methods and apparatus for preparing to analyze and analyzing the sample for identification of fetal genetic material as part of prenatal genetic testing. The invention also pertains to methods and apparatus for discriminating fetal nucleated red blood cells from maternal nucleated red blood cells obtained from a blood sample taken from a pregnant woman.
摘要翻译： 在母体全血样品中浓缩和分离有核细胞如母体和胎儿有核红细胞（nRBC）的方法。 本发明还提供了用于分析和分析用于鉴定胎儿遗传物质的样品作为产前遗传测试的一部分的方法和装置。 本发明还涉及从从孕妇采集的血液样品获得的母体成核红细胞中区分胎儿有核红细胞的方法和装置。
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公开(公告)号：US20130137137A1
公开(公告)日：2013-05-30
申请号：US13643614
申请日：2011-05-09
IPC分类号： G01N1/28
CPC分类号： G01N1/2813 , C12Q1/6841 , C12Q1/6881 , C12Q2600/158 , G02B21/34
摘要： A method of creating a layer of cells on a surface. In some embodiments, the method includes the steps of engaging a smear tool against the surface with an engagement force; flexing a portion of the smear tool to change an orientation of the smear tool with respect to the surface; moving the smear tool along the surface through a sample comprising cells suspended in a liquid; and adhering the sample to the surface to thereby create a layer of cells. Another method according to the invention creates a layer of cells on a surface by mixing the sample prior to and/or during the smear. The invention also includes systems for implementing the methods.
摘要翻译： 在表面上创建细胞层的方法。 在一些实施例中，该方法包括以下步骤：使涂抹工具以接合力与表面接合; 挠曲涂抹工具的一部分以改变涂抹工具相对于表面的取向; 通过包含悬浮在液体中的细胞的样品沿着表面移动涂片工具; 并将样品粘附到表面，从而形成一层细胞。 根据本发明的另一种方法通过在涂片之前和/或期间混合样品来在表面上产生一层细胞。 本发明还包括用于实现该方法的系统。
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3.发明授权Method and device for identification of nucleated red blood cells from a maternal blood sample 失效用于从母体血液样品中鉴定有核红细胞的方法和装置公开(公告)号：US08426122B2
公开(公告)日：2013-04-23
申请号：US13247896
申请日：2011-09-28
CPC分类号： C12Q1/6806 , C12N5/0087
摘要： A method for concentrating and isolating nucleated cells, such as a maternal and fetal nucleated red blood cells (NRBC's), in a maternal whole blood sample. The invention also provides methods and apparatus for preparing to analyze and analyzing the sample for identification of fetal genetic material as part of prenatal genetic testing. The invention also pertains to methods and apparatus for discriminating fetal nucleated red blood cells from maternal nucleated red blood cells obtained from a blood sample taken from a pregnant woman.
摘要翻译： 在母体全血样品中浓缩和分离有核细胞如母体和胎儿有核红细胞（NRBC's）的方法。 本发明还提供了用于分析和分析用于鉴定胎儿遗传物质的样品作为产前遗传测试的一部分的方法和装置。 本发明还涉及从从孕妇采集的血液样品获得的母体成核红细胞中区分胎儿有核红细胞的方法和装置。
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4.发明申请Method and Device for Identification of Nucleated Red Blood Cells from a Maternal Blood Sample 失效用于从孕妇血液样品鉴定核红细胞的方法和装置公开(公告)号：US20110311960A1
公开(公告)日：2011-12-22
申请号：US13046543
申请日：2011-03-11
CPC分类号： C12Q1/6806 , C12N5/0087
摘要： A method for concentrating and isolating nucleated cells, such as a maternal and fetal nucleated red blood cells (NRBC's), in a maternal whole blood sample. The invention also provides methods and apparatus for preparing to analyze and analyzing the sample for identification of fetal genetic material as part of prenatal genetic testing. The invention also pertains to methods and apparatus for discriminating fetal nucleated red blood cells from maternal nucleated red blood cells obtained from a blood sample taken from a pregnant woman.
摘要翻译： 在母体全血样品中浓缩和分离有核细胞如母体和胎儿有核红细胞（NRBC's）的方法。 本发明还提供了用于分析和分析用于鉴定胎儿遗传物质的样品作为产前遗传测试的一部分的方法和装置。 本发明还涉及从从孕妇采集的血液样品获得的母体成核红细胞中区分胎儿有核红细胞的方法和装置。
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5.发明申请公开(公告)号：US20100159506A1
公开(公告)日：2010-06-24
申请号：US12509945
申请日：2009-07-27
申请人： Bhairavi Parikh , James Stone , Michael D. Brody , Vivek Balasubramanyam , Jonathan D. Halderman
发明人： Bhairavi Parikh , James Stone , Michael D. Brody , Vivek Balasubramanyam , Jonathan D. Halderman
IPC分类号： C12Q1/06
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： Methods for determining genetic status of a fetus from a sample of maternal blood comprise enriching nucleated red blood cells in the sample, including both fetal and maternal nucleated red blood cells. The nucleated red blood cells are then differentiated from all other blood cells in the enriched sample, and the nucleated red blood cells genetically screened to determine the genetic status. The nucleated red blood cells may be differentiated by immobilizing all enriched blood cells on a solid phase and locating the nucleated red blood cells for interrogation. Optionally, the nucleated red blood cells may be sorted and separated from other enriched blood cells in a liquid phase.
摘要翻译： 从母体血液样本确定胎儿遗传状态的方法包括富集样品中的有核红细胞，包括胎儿和母体成核红细胞。 然后将有核的红细胞与富集样品中的所有其他血细胞分化，并对有核红细胞进行遗传筛选以确定遗传状态。 可以通过将所有富集的血细胞固定在固相上并将有核红细胞定位用于询问来分化有核红细胞。 任选地，可以将有核红细胞与液相中的其它富集血细胞分离和分离。
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6.发明申请METHOD AND DEVICE FOR IDENTIFICATION OF NUCLEATED RED BLOOD CELLS FROM A MATERNAL BLOOD SAMPLE 审中-公开用于鉴定来自母体血液样品的核仁红细胞的方法和装置公开(公告)号：US20140255934A1
公开(公告)日：2014-09-11
申请号：US14285260
申请日：2014-05-22
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , C12N5/0087
摘要： A method for concentrating and isolating nucleated cells, such as maternal and fetal nucleated red blood cells (NRBC's), in a maternal whole blood sample. The invention also provides methods and apparatus for preparing to analyze and analyzing the sample for identification of fetal genetic material as part of prenatal genetic testing. The invention also pertains to methods and apparatus for discriminating fetal nucleated red blood cells from maternal nucleated red blood cells obtained from a blood sample taken from a pregnant woman.
摘要翻译： 在母体全血样品中浓缩和分离有核细胞如母体和胎儿有核红细胞（NRBC's）的方法。 本发明还提供了用于分析和分析用于鉴定胎儿遗传物质的样品作为产前遗传测试的一部分的方法和装置。 本发明还涉及从从孕妇采集的血液样品获得的母体成核红细胞中区分胎儿有核红细胞的方法和装置。
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7.发明授权Method and device for identification of nucleated red blood cells from a maternal blood sample 失效用于从母体血液样品中鉴定有核红细胞的方法和装置公开(公告)号：US08774488B2
公开(公告)日：2014-07-08
申请号：US13046543
申请日：2011-03-11
IPC分类号： G06K9/00 , A61K39/395 , C12N5/071
CPC分类号： C12Q1/6806 , C12N5/0087
摘要： A method for concentrating and isolating nucleated cells, such as a maternal and fetal nucleated red blood cells (NRBC's), in a maternal whole blood sample. The invention also provides methods and apparatus for preparing to analyze and analyzing the sample for identification of fetal genetic material as part of prenatal genetic testing. The invention also pertains to methods and apparatus for discriminating fetal nucleated red blood cells from maternal nucleated red blood cells obtained from a blood sample taken from a pregnant woman.
摘要翻译： 在母体全血样品中浓缩和分离有核细胞如母体和胎儿有核红细胞（NRBC's）的方法。 本发明还提供了用于分析和分析用于鉴定胎儿遗传物质的样品作为产前遗传测试的一部分的方法和装置。 本发明还涉及从从孕妇采集的血液样品获得的母体成核红细胞中区分胎儿有核红细胞的方法和装置。
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公开(公告)号：US20130130930A1
公开(公告)日：2013-05-23
申请号：US13681274
申请日：2012-11-19
申请人： Bhairavi PARIKH , Michael D. BRODY , James STONE , Brian AWABDY , Urvi VED , Anh TRAN , Patrick J. COLLINS , David J. ANVAR
发明人： Bhairavi PARIKH , Michael D. BRODY , James STONE , Brian AWABDY , Urvi VED , Anh TRAN , Patrick J. COLLINS , David J. ANVAR
IPC分类号： C12Q1/68
CPC分类号： G01N33/5005 , C12Q1/68 , C12Q1/6806 , C12Q1/686 , C12Q1/6883 , G01N33/689
摘要： A method for concentrating and isolating nucleated cells, such as maternal and fetal nucleated red blood cells (nRBCs), in a maternal whole blood sample. The invention also provides methods and apparatus for preparing to analyze and analyzing the sample for identification of fetal genetic material as part of prenatal genetic testing. The invention also pertains to methods and apparatus for discriminating fetal nucleated red blood cells from maternal nucleated red blood cells obtained from a blood sample taken from a pregnant woman.
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公开(公告)号：US20130130929A1
公开(公告)日：2013-05-23
申请号：US13681251
申请日：2012-11-19
申请人： Bhairavi PARIKH , Michael D. Brody , James Stone , Brian Awabdy , Urvi Ved , Anh Tran , Patrick J. Collins , David J. Anvar
发明人： Bhairavi PARIKH , Michael D. Brody , James Stone , Brian Awabdy , Urvi Ved , Anh Tran , Patrick J. Collins , David J. Anvar
IPC分类号： C12Q1/68
CPC分类号： G01N33/5005 , C12Q1/68 , C12Q1/6806 , C12Q1/686 , C12Q1/6883 , G01N33/689
摘要： A method for concentrating and isolating nucleated cells, such as maternal and fetal nucleated red blood cells (nRBCs), in a maternal whole blood sample. The invention also provides methods and apparatus for preparing to analyze and analyzing the sample for identification of fetal genetic material as part of prenatal genetic testing. The invention also pertains to methods and apparatus for discriminating fetal nucleated red blood cells from maternal nucleated red blood cells obtained from a blood sample taken from a pregnant woman.
摘要翻译： 在母体全血样品中浓缩和分离有核细胞如母体和胎儿有核红细胞（nRBC）的方法。 本发明还提供了用于分析和分析用于鉴定胎儿遗传物质的样品作为产前遗传测试的一部分的方法和装置。 本发明还涉及从从孕妇采集的血液样品获得的母体成核红细胞中区分胎儿有核红细胞的方法和装置。
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10.发明申请Method and Device for Identification of Nucleated Red Blood Cells from a Maternal Blood Sample 失效用于从孕妇血液样品鉴定核红细胞的方法和装置公开(公告)号：US20120021508A1
公开(公告)日：2012-01-26
申请号：US13247896
申请日：2011-09-28
IPC分类号： C12N5/078
CPC分类号： C12Q1/6806 , C12N5/0087
摘要： A method for concentrating and isolating nucleated cells, such as a maternal and fetal nucleated red blood cells (NRBC's), in a maternal whole blood sample. The invention also provides methods and apparatus for preparing to analyze and analyzing the sample for identification of fetal genetic material as part of prenatal genetic testing. The invention also pertains to methods and apparatus for discriminating fetal nucleated red blood cells from maternal nucleated red blood cells obtained from a blood sample taken from a pregnant woman.
摘要翻译： 在母体全血样品中浓缩和分离有核细胞如母体和胎儿有核红细胞（NRBC's）的方法。 本发明还提供了用于分析和分析用于鉴定胎儿遗传物质的样品作为产前遗传测试的一部分的方法和装置。 本发明还涉及从从孕妇采集的血液样品获得的母体成核红细胞中区分胎儿有核红细胞的方法和装置。
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