摘要:
Compounds of formula as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R3 have the significance given in the application and which can be used in the form of pharmaceutical compositions.
摘要:
The invention provides genetic suppressor elements that are derived from the apoptosis-related gene BCL2. The invention provides genetic suppressor elements that are capable of inhibiting BCL2 gene expression and BCL2-mediated suppression of apoptosis in mammalian cells. The GSEs provided by the invention are also useful for sensitizing cancer cells to the cytotoxic effects of chemotherapeutic drugs. The invention provides methods for identifying and obtaining such elements, and therapeutic methods of using such elements for treatment of cancer cells and animals bearing malignant tumors.
摘要:
This invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a GCR gene. The invention also relates to a pharmaceutical composition comprising the dsRNA or nucleic acid molecules or vectors encoding the same together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of a GCR gene using said pharmaceutical composition; and methods for inhibiting the expression of GCR in a cell.
摘要:
Compounds of formula as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R3 have the significance given in the application and which can be used in the form of pharmaceutical compositions.