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公开(公告)号：US10201692B2
公开(公告)日：2019-02-12
申请号：US14848062
申请日：2015-09-08
申请人： Byeong Seon Chang
发明人： Byeong Seon Chang
摘要： The present specification discloses a solution delivery device having a container component and a plug component configured for selective engagement with the container component. The container component has an internal cavity including an elongated mixing channel containing a first constituent, and the plug component provides an internal flow path configured for introduction of a second constituent into the mixing channel for mixing with the first constituent. The plug component may be inserted within the container component partially in a first operational mode and fully in a second operational mode. The first constituent may be a drug and the second constituent a diluent, such that the drug may be lyophilized with the device in the first operational mode and reconstituted with the device in the second operational mode. Multiple devices may be employed in tandem for the co-delivery of multiple constituents. The device may be included in a kit or installed within an injector.
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公开(公告)号：US20190021950A1
公开(公告)日：2019-01-24
申请号：US16139785
申请日：2018-09-24
申请人： Byeong Seon Chang
发明人： Byeong Seon Chang
摘要： A container usable for lyophilization, storage, and reconstitution of medication having only two parts, one of which is a plug component having a flow path terminating in a side outlet port and a second of which is a barrel component. The barrel component has a spiral mixing channel near its distal end in which powder medication is stored and upon reconstitution, yields a gradient concentration. The inner wall of the barrel includes a longitudinal diluent groove. To connect the plug outlet port with the longitudinal diluent groove, the plug or barrel has a 360° distribution groove encircling the plug and connecting to the plug outlet port. Regardless of what rotational orientation the plug has to the barrel, the diluent will always reach the mixing channel.
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公开(公告)号：US07959600B2
公开(公告)日：2011-06-14
申请号：US11716223
申请日：2007-03-09
IPC分类号： A61M37/00
CPC分类号： A61M5/31 , A61J1/2096 , A61M5/2448 , A61M5/31596 , A61M5/3294 , A61M5/34 , A61M5/345 , A61M2005/312 , A61M2005/3128 , A61M2005/3132 , A61M2005/31598
摘要： A container closure delivery system that is suitable for lyophilized pharmaceutical injectable powder products is disclosed. The system comprises storage stable powder formulations and a container closure assembly design wherein the formulation can be filled and lyophilized with a standard fill finish equipment, and the formulations and lyophilization processes are optimized to produce a powder that readily dissolves upon contact with a diluent, thereby facilitating the direct injection of the lyophilized product without the need for a separate reconstitution/mixing/priming step.
摘要翻译： 公开了适用于冻干药物可注射粉末产品的容器封闭递送系统。 该系统包括储存稳定的粉末制剂和容器封闭组件设计，其中可以用标准填充装置填充和冻干制剂，并优化制剂和冻干方法以产生在与稀释剂接触时容易溶解的粉末，从而 促进直接注射冻干产品，而不需要单独的重建/混合/起动步骤。
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公开(公告)号：US20090186819A1
公开(公告)日：2009-07-23
申请号：US12333276
申请日：2008-12-11
申请人： Marieve Carrier , Byeong Seon Chang , Omar Quraishi , Thomas R. Ulich , Maggie Wang , Jean-Philippe Estradier
发明人： Marieve Carrier , Byeong Seon Chang , Omar Quraishi , Thomas R. Ulich , Maggie Wang , Jean-Philippe Estradier
CPC分类号： A61K9/0019 , A61K47/643
摘要： The present invention provides pharmaceutical formulations comprising insulinotropic peptide conjugates, particularly a conjugate of albumin to exendin-4, or a derivative thereof, and methods of administration thereof. The present invention also provides methods for treating diabetes and insulinotropic peptides related diseases or conditions by administering the pharmaceutical formulations described herein.
摘要翻译： 本发明提供包含促胰岛素肽缀合物，特别是白蛋白与毒蜥外泌肽-4的缀合物或其衍生物的药物制剂及其施用方法。 本发明还提供了通过施用本文所述的药物制剂治疗糖尿病和促胰岛素肽相关疾病或病症的方法。
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公开(公告)号：US10894152B2
公开(公告)日：2021-01-19
申请号：US16230596
申请日：2018-12-21
申请人： Byeong Seon Chang
发明人： Byeong Seon Chang
摘要： The present specification discloses a solution delivery device having a container component and a plug component configured for selective engagement with the container component. The container component has an internal cavity including an elongated mixing channel containing a first constituent, and the plug component provides an internal flow path configured for introduction of a second constituent into the mixing channel for mixing with the first constituent. The plug component may be inserted within the container component partially in a first operational mode and fully in a second operational mode. The first constituent may be a drug and the second constituent a diluent, such that the drug may be lyophilized with the device in the first operational mode and reconstituted with the device in the second operational mode. Multiple devices may be employed in tandem for the co-delivery of multiple constituents. The device may be included in a kit or installed within an injector.
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公开(公告)号：US20140127227A1
公开(公告)日：2014-05-08
申请号：US13662281
申请日：2012-10-26
申请人： Byeong Seon Chang
发明人： Byeong Seon Chang
IPC分类号： A61K47/18 , C07K16/28 , C07K16/10 , A61K38/48 , A61K38/57 , A61K38/47 , C07K16/24 , C07K16/22
CPC分类号： A61K47/183 , A61K38/47 , A61K38/4846 , A61K38/57 , A61K39/39591 , A61K47/22 , C07K16/1027 , C07K16/22 , C07K16/241 , C07K16/2863 , C07K16/2866 , C07K16/2887 , C07K16/32 , C07K2317/24 , C07K2317/94 , C12Y302/01022 , C12Y302/01045 , C12Y304/21022
摘要： Provided are stable protein formulations that contain at least one amino acid. In certain embodiments, amino acid combinations either at least two, or three, or four, or more amino acids are included. By virtue of inclusion of the amino acids, the formulation has low viscosity and a protein in the formulations is physically, chemically, and biological stable even at high concentrations. In further embodiments, by virtue of inclusion of the amino acids, a protein in the formulations is physically, chemically, and biological stable even at high concentrations.
摘要翻译： 提供含有至少一个氨基酸的稳定的蛋白质制剂。 在某些实施方案中，包括至少两个或三个，四个或更多个氨基酸的氨基酸组合。 由于包含氨基酸，制剂具有低粘度，即使在高浓度下，制剂中的蛋白质也具有物理，化学和生物学稳定性。 在另外的实施方案中，由于包含氨基酸，即使在高浓度下，制剂中的蛋白质也是物理，化学和生物稳定的。
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公开(公告)号：US20130319885A1
公开(公告)日：2013-12-05
申请号：US13978861
申请日：2012-01-10
申请人： Byeong Seon Chang
发明人： Byeong Seon Chang
IPC分类号： A61J1/20
CPC分类号： A61J1/20 , A61M5/2448 , A61M5/31 , A61M5/31596 , A61M5/3294 , A61M5/34 , A61M5/345 , A61M2005/312 , A61M2005/3128
摘要： A container usable for lyophilization, storage, and reconstitution of medication having only two parts, one of which is a plug component having a flow path terminating in a side outlet port and a second of which is a barrel component. The barrel component has a spiral mixing channel near its distal end in which powder medication is stored and upon reconstitution, yields a gradient concentration. The inner wall of the barrel includes a longitudinal diluent groove. To connect the plug outlet port with the longitudinal diluent groove, the plug or barrel has a 360° distribution groove encircling the plug and connecting to the plug outlet port. Regardless of what rotational orientation the plug has to the barrel, the diluent will always reach the mixing channel.
摘要翻译： 可用于冷冻干燥，储存和重建仅具有两部分的药物的容器，其中一个是具有终止于侧出口端口的流路的插塞部件，其中第二部分是桶部件。 桶组件在其远端附近具有螺旋混合通道，其中存储粉末药物并且在重新构成时，产生梯度浓度。 筒的内壁包括纵向稀释槽。 为了将插头出口与纵向稀释槽连接，插头或圆筒具有环绕插头的360°分配槽并连接到插头出口。 不管塞子对桶的旋转方向如何，稀释剂将始终到达混合通道。
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公开(公告)号：US20130261046A1
公开(公告)日：2013-10-03
申请号：US13902602
申请日：2013-05-24
申请人： Byeong Seon Chang
IPC分类号： A61J1/00
CPC分类号： A61J1/00 , A61M5/2448 , A61M5/31596 , A61M2005/312 , A61M2005/3128 , A61M2005/31598
摘要： The present invention relates to a container closure delivery system that is suitable for lyophilized pharmaceutical injectable powder products. The system comprises storage stable powder formulations and a container closure assembly design wherein the formulation can be filled and lyophilized with a standard fill finish equipment, and the formulations and lyophilization processes are optimized to produce a powder that readily dissolves upon contact with a diluent, thereby facilitating the direct injection of the lyophilized product without the need for a separate reconstitution/mixing/priming step.
摘要翻译： 本发明涉及适用于冻干药物可注射粉末产品的容器封闭递送系统。 该系统包括储存稳定的粉末制剂和容器封闭组件设计，其中可以用标准填充装置填充和冻干制剂，并优化制剂和冻干方法以产生在与稀释剂接触时容易溶解的粉末，从而 促进直接注射冻干产品，而不需要单独的重建/混合/起动步骤。
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公开(公告)号：US10105285B2
公开(公告)日：2018-10-23
申请号：US15290538
申请日：2016-10-11
申请人： Byeong Seon Chang
发明人： Byeong Seon Chang
摘要： A container usable for lyophilization, storage, and reconstitution of medication having only two parts, one of which is a plug component having a flow path terminating in a side outlet port and a second of which is a barrel component. The barrel component has a spiral mixing channel near its distal end in which powder medication is stored and upon reconstitution, yields a gradient concentration. The inner wall of the barrel includes a longitudinal diluent groove. To connect the plug outlet port with the longitudinal diluent groove, the plug or barrel has a 360° distribution groove encircling the plug and connecting to the plug outlet port. Regardless of what rotational orientation the plug has to the barrel, the diluent will always reach the mixing channel.
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公开(公告)号：US09463139B2
公开(公告)日：2016-10-11
申请号：US13978861
申请日：2012-01-10
申请人： Byeong Seon Chang
发明人： Byeong Seon Chang
CPC分类号： A61J1/20 , A61M5/2448 , A61M5/31 , A61M5/31596 , A61M5/3294 , A61M5/34 , A61M5/345 , A61M2005/312 , A61M2005/3128
摘要： A container usable for lyophilization, storage, and reconstitution of medication having only two parts, one of which is a plug component having a flow path terminating in a side outlet port and a second of which is a barrel component. The barrel component has a spiral mixing channel near its distal end in which powder medication is stored and upon reconstitution, yields a gradient concentration. The inner wall of the barrel includes a longitudinal diluent groove. To connect the plug outlet port with the longitudinal diluent groove, the plug or barrel has a 360° distribution groove encircling the plug and connecting to the plug outlet port. Regardless of what rotational orientation the plug has to the barrel, the diluent will always reach the mixing channel.
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