公开(公告)号：US6152471A

公开(公告)日：2000-11-28

申请号：US142372

申请日：1998-09-04

申请人： Byung Nam Kang ,  Jong suk Kim ,  Hye Jong Park

发明人： Byung Nam Kang ,  Jong suk Kim ,  Hye Jong Park

IPC分类号： B62M9/00 ,  B62M3/04 ,  B62M1/02 ,  G05G1/14

CPC分类号： B62M3/04 ,  Y10T74/2167

摘要： A variable pedal driving device for a bicycle, the device allowing the bicycle pedals to slide along crankshafts during operation of the device. Each pedal is coupled to a slide pipe slidably mounted on a crankshaft. The slide pipe is in turn connected to an eccentric member mounted on the main shaft of the driving device. When a pedal is driven in a forward direction, the eccentric member causes the pedal to extend out to a maximum distance from the main shaft, for more efficient driving of the bicycle.

摘要翻译： PCT No.PCT / KR97 / 00284 Sec。 371日期：1998年9月4日 102（e）1998年9月4日PCT PCT 1997年12月31日PCT公布。 公开号WO98 / 29295 日期1998年7月9日用于自行车的可变踏板驱动装置，该装置允许自行车踏板在装置的操作期间沿曲轴滑动。 每个踏板联接到可滑动地安装在曲轴上的滑动管。 滑动管又连接到安装在驱动装置的主轴上的偏心构件。 当踏板沿向前方向被驱动时，偏心构件使踏板从主轴延伸到最大距离，以便更有效地驾驶自行车。

公开(公告)号：US20120053180A1

公开(公告)日：2012-03-01

申请号：US13050801

申请日：2011-03-17

申请人： Sang Uk Kang ,  Min Jeong Kim ,  Byung Nam Kang ,  Wei Tan ,  Albert Charles Gyorkos ,  Suk Young Cho

发明人： Sang Uk Kang ,  Min Jeong Kim ,  Byung Nam Kang ,  Wei Tan ,  Albert Charles Gyorkos ,  Suk Young Cho

IPC分类号： A61K31/501 ,  A61K31/496 ,  C07D239/34 ,  A61K31/505 ,  C07D241/04 ,  A61K31/495 ,  C07D403/04 ,  C07D211/96 ,  A61K31/445 ,  C07D213/68 ,  A61K31/4412 ,  C07C69/22 ,  A61K31/222 ,  C07C317/22 ,  A61K31/085 ,  C07C43/235 ,  A61P3/00 ,  A61P3/10 ,  A61P9/00 ,  C07D403/12

CPC分类号： C07D403/12 ,  C07C43/247 ,  C07C317/22 ,  C07C317/44 ,  C07C2601/14 ,  C07D211/96 ,  C07D237/22 ,  C07D239/34 ,  C07D295/096 ,  C07D417/12 ,  C07D417/14 ,  C07D451/06 ,  C07D451/10 ,  C07D471/04

摘要： This invention relates to a series of substituted cyclohexane containing analogues which are agonists of GPR119 intended to treat metabolic diseases mediated by GPR119 including Type I & II diabetes mellitus. Diabetes mellitus is an ever-increasing threat to human health causing various complications (blindness, kidney failure, neuropathy, heart attack, stroke, etc.). Recently it was found that activation of GPR119 which is highly expressed in pancreatic beta cells causes glucose dependent insulin secretion and GLP-1 release. Many pharmaceuticals are currently developing GPR119 agonists and herein we disclose alternative GPR119 agonists. Our invention describes GPR119 agonists having structural Formula (I), pharmaceutically acceptable salt or solvate of Formula (I), isomer or prodrug of Formula (I), and combination therapy of Formula (I) with other anti-diabetic drugs like DPP-IV inhibitors and/or insulin sensitizers.

摘要翻译： 本发明涉及一系列取代的含环己烷的类似物，其是旨在治疗包括I型和II型糖尿病的GPR119介导的代谢疾病的GPR119的激动剂。 糖尿病是导致各种并发症（失明，肾衰竭，神经病，心脏病发作，中风等）的人类健康日益严重的威胁。 最近发现，在胰腺β细胞中高度表达的GPR119的激活导致葡萄糖依赖性胰岛素分泌和GLP-1释放。 许多药物目前正在开发GPR119激动剂，在此我们公开了另外的GPR119激动剂。 我们的发明描述了具有结构式（I），式（I）的药学上可接受的盐或溶剂化物，式（I）的异构体或前药，以及式（I）与其它抗糖尿病药物如DPP-IV的组合治疗的GPR119激动剂 抑制剂和/或胰岛素敏化剂。

公开(公告)号：US06508146B2

公开(公告)日：2003-01-21

申请号：US09873180

申请日：2001-06-05

申请人： Byung-Nam Kang ,  Jong-Suk Kim ,  Hye-Jong Park

发明人： Byung-Nam Kang ,  Jong-Suk Kim ,  Hye-Jong Park

IPC分类号： G05G114

CPC分类号： B62M3/04 ,  Y10T74/2164 ,  Y10T74/2167

摘要： A pedal driving mechanism for a bicycle which contains structurally improved pedal arms on which pedals are installed to increase the rotary radius of the pedals during the running of the bicycle to obtain optimum driving energy with minimum physical energy consumption, wherein the structure of pedaling mechanism defines a joining line formed by the tooth-coupling of a fixing gear and a rotary gear with the axle line of a driving arm at a right angle, and the trace of the linkage formed by a connection arm and a connection link is set to move in a spiral motion forced to rotate with respect to the center of the fixing gear.