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1.发明授权Indazoles, benzothiazoles, and benzoisothiazoles, and preparation and uses thereof 失效吲唑，苯并噻唑和苯并异噻唑，及其制备和用途公开(公告)号：US08134003B2
公开(公告)日：2012-03-13
申请号：US13103512
申请日：2011-05-09
Applicant: Wenge Xie , Brian Herbert , Truc Nguyen , Carla Gauss , Ashok Tehim
Inventor： Wenge Xie , Brian Herbert , Truc Nguyen , Carla Gauss , Ashok Tehim
IPC: C07D211/02
CPC classification number: C07D453/02
Abstract: The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nAChR), activation of nAChRs, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds (indazoles and benzothiazoles), which act as ligands for the α7 nAChR subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.
Abstract translation: 本发明一般涉及烟碱乙酰胆碱受体（nAChR）的配体领域，nAChR的活化以及与缺陷或功能不良的烟碱乙酰胆碱受体，特别是脑的疾病相关的疾病状况的治疗。 此外，本发明涉及作为α7nAChR亚型的配体的新化合物（吲唑和苯并噻唑），制备这些化合物的方法，含有这些化合物的组合物及其使用方法。
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2.发明授权Indazoles, benzothiazoles, and benzoisothiazoles, and preparation and uses thereof 失效吲唑，苯并噻唑和苯并异噻唑，及其制备和用途公开(公告)号：US07429664B2
公开(公告)日：2008-09-30
申请号：US10669645
申请日：2003-09-25
Applicant: Wenge Xie , Brian Herbert , Truc Nguyen , Carla Gauss , Ashok Tehim
Inventor： Wenge Xie , Brian Herbert , Truc Nguyen , Carla Gauss , Ashok Tehim
IPC: C07D217/00 , C07D221/02
CPC classification number: C07D453/02
Abstract: The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nAChR), activation of nAChRs, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds (indazoles and benzothiazoles), which act as ligands for the α7 nAChR subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.
Abstract translation: 本发明一般涉及烟碱乙酰胆碱受体（nAChR）的配体领域，nAChR的活化以及与缺陷或功能不良的烟碱乙酰胆碱受体，特别是脑的疾病相关的疾病状况的治疗。 此外，本发明涉及作为α7nAChR亚型的配体的新化合物（吲唑和苯并噻唑），制备这些化合物的方法，含有这些化合物的组合物及其使用方法。
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公开(公告)号：US20070265270A1
公开(公告)日：2007-11-15
申请号：US11708868
申请日：2007-02-20
Applicant: Stephen Hitchcock , Ruiping Liu , Mark Arrington , Allen Hopper , Richard Conticello , Truc Nguyen , M. Danca , Carla Gauss
Inventor： Stephen Hitchcock , Ruiping Liu , Mark Arrington , Allen Hopper , Richard Conticello , Truc Nguyen , M. Danca , Carla Gauss
IPC: A61K31/502 , A61K31/5375 , A61P25/00 , A61P25/18 , A61P3/00 , C07D237/28 , C07D295/00
CPC classification number: C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14
Abstract: The present invention is directed to certain cinnoline compounds that are PDE10 inhibitors, pharmaceutical compositions containing such compounds and process for preparing such compounds. The invention is also directed to methods of treating diseases treatable by modulation of PDE10 enzyme, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.
Abstract translation: 本发明涉及某些作为PDE10抑制剂的噌啉化合物，含有这些化合物的药物组合物及其制备方法。 本发明还涉及治疗通过调节PDE10酶可治疗的疾病的方法，例如肥胖症，非胰岛素依赖型糖尿病，精神分裂症，双相情感障碍，强迫症等。
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公开(公告)号：US20070265256A1
公开(公告)日：2007-11-15
申请号：US11708866
申请日：2007-02-20
Applicant: Mark Arrington , Ruiping Liu , Allen Hopper , Richard Conticello , Truc Nguyen , Carla Gauss , Roland Burli , Stephen Hitchcock , Essa Hu , Roxanne Kunz , Thomas Nixey , Shannon Rumfelt , Nign Chen
Inventor： Mark Arrington , Ruiping Liu , Allen Hopper , Richard Conticello , Truc Nguyen , Carla Gauss , Roland Burli , Stephen Hitchcock , Essa Hu , Roxanne Kunz , Thomas Nixey , Shannon Rumfelt , Nign Chen
IPC: A61K31/535 , A61K31/50 , A61P25/18 , C07D237/26 , C07D413/00
CPC classification number: C07D237/28 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/10 , C07D405/14 , C07D409/10 , C07D409/14 , C07D413/04 , C07D413/10 , C07D413/14 , C07D417/04 , C07D417/10 , C07D417/14 , C07D471/04 , C07D487/04 , C07D513/04
Abstract: The present invention is directed to certain cinnoline compounds that are PDE10 inhibitors, pharmaceutical compositions containing such compounds and process for preparing such compounds. This invention is also directed to methods of treating diseases treatable by inhibition of PDE10 enzyme, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.
Abstract translation: 本发明涉及某些作为PDE10抑制剂的噌啉化合物，含有这些化合物的药物组合物及其制备方法。 本发明还涉及通过抑制PDE10酶如肥胖症，非胰岛素依赖型糖尿病，精神分裂症，双相情感障碍，强迫症等治疗疾病的方法。
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5.发明申请1H-indazoles, benzothiazoles, 1,2-benzoisoxazoles, 1,2-benzoisothiazoles, and chromones and preparation and uses thereof 失效1H-吲唑，苯并噻唑，1,2-苯并异恶唑，1,2-苯并异噻唑和色酮及其制备和用途公开(公告)号：US20050272735A1
公开(公告)日：2005-12-08
申请号：US11123219
申请日：2005-05-06
Applicant: Wenge Xie , Brian Herbert , Richard Schumacher , Jianguo Ma , Truc Nguyen , Carla Gauss , Ashok Tehim
Inventor： Wenge Xie , Brian Herbert , Richard Schumacher , Jianguo Ma , Truc Nguyen , Carla Gauss , Ashok Tehim
IPC: C07D471/08 , C07D487/08 , A61K31/498 , C07D487/04
CPC classification number: C07D471/08 , C07D487/08
Abstract: The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nAChR), activation of nAChRs, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds (indazoles and benzothiazoles), which act as ligands for the α7 nAChR subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.
Abstract translation: 本发明一般涉及烟碱乙酰胆碱受体（nAChR）的配体领域，nAChR的活化以及与缺陷或功能不良的烟碱乙酰胆碱受体，特别是脑的疾病相关的疾病状况的治疗。 此外，本发明涉及作为α7nAChR亚型的配体的新化合物（吲唑和苯并噻唑），制备这些化合物的方法，含有这些化合物的组合物及其使用方法。
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Patent Agency Ranking
6.发明申请INDAZOLES, BENZOTHIAZOLES, AND BENZOISOTHIAZOLES, AND PREPARATION AND USES THEREOF 失效伊佐唑，苯并噻唑和苯并噻唑及其制备及用途公开(公告)号：US20120101094A1
公开(公告)日：2012-04-26
申请号：US13338835
申请日：2011-12-28
Applicant: Wenge XIE , Brian HERBERT , Truc NGUYEN , Carla GAUSS , Ashok TEHIM
Inventor： Wenge XIE , Brian HERBERT , Truc NGUYEN , Carla GAUSS , Ashok TEHIM
IPC: A61K31/439 , A61K31/444 , A61P25/18 , C07D453/02 , A61K31/5377 , A61P25/28
CPC classification number: C07D453/02
Abstract: The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nAChR), activation of nAChRs, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds (indazoles and benzothiazoles), which act as ligands for the α7 nAChR subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.
Abstract translation: 本发明一般涉及烟碱乙酰胆碱受体（nAChR）的配体领域，nAChR的活化以及与缺陷或功能不良的烟碱乙酰胆碱受体，特别是脑的疾病相关的疾病状况的治疗。 此外，本发明涉及作为α7nAChR亚型的配体的新化合物（吲唑和苯并噻唑），制备这些化合物的方法，含有这些化合物的组合物及其使用方法。
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7.发明授权Indazoles, benzothiazoles, and benzoisothiazoles, and preparation and uses thereof 有权吲唑，苯并噻唑和苯并异噻唑，及其制备和用途公开(公告)号：US07943773B2
公开(公告)日：2011-05-17
申请号：US12430944
申请日：2009-04-28
Applicant: Wenge Xie , Brian Herbert , Truc Nguyen , Carla Gauss , Ashok Tehim
Inventor： Wenge Xie , Brian Herbert , Truc Nguyen , Carla Gauss , Ashok Tehim
IPC: C07D221/02
CPC classification number: C07D453/02
Abstract: The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nAChR), activation of nAChRs, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds (indazoles and benzothiazoles), which act as ligands for the α7 nAChR subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.
Abstract translation: 本发明一般涉及烟碱乙酰胆碱受体（nAChR）的配体领域，nAChR的活化以及与缺陷或功能不良的烟碱乙酰胆碱受体，特别是脑的疾病相关的疾病状况的治疗。 此外，本发明涉及作为α7nAChR亚型的配体的新化合物（吲唑和苯并噻唑），制备这些化合物的方法，含有这些化合物的组合物及其使用方法。
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公开(公告)号：US20060160814A1
公开(公告)日：2006-07-20
申请号：US11217664
申请日：2005-09-02
Applicant: Mark Arrington , Ruiping Liu , Richard Conticello , Carla Gauss , Allen Hopper , Truc Nguyen , Ashok Tehim
Inventor： Mark Arrington , Ruiping Liu , Richard Conticello , Carla Gauss , Allen Hopper , Truc Nguyen , Ashok Tehim
IPC: A61K31/502 , C07D403/02
CPC classification number: C07D495/04 , C07D237/28 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14
Abstract: The present disclosure relates generally to the field of phosphodiesterase 10 (PDE10) enzyme inhibition by cinnoline compounds of Formulas I and II: wherein R1—R3 and R15—R18 are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.
Abstract translation: 本公开一般涉及由式I和II的噌啉化合物抑制磷酸二酯酶10（PDE10）的领域：其中R 1〜R 3和R 3' 15R-18是如本文所定义的。 本公开还涉及制备这种化合物的方法，含有这些化合物的组合物及其使用方法。
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9.发明申请Indoles, 1H-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, and preparation and uses thereof 失效吲哚，1H-吲唑，1,2-苯并异恶唑和1,2-苯并异噻唑，及其制备和用途公开(公告)号：US20050176754A1
公开(公告)日：2005-08-11
申请号：US11018429
申请日：2004-12-22
Applicant: Wenge Xie , Brian Herbert , Jianguo Ma , Truc Nguyen , Richard Schumacher , Carla Gauss , Ashok Tehim
Inventor： Wenge Xie , Brian Herbert , Jianguo Ma , Truc Nguyen , Richard Schumacher , Carla Gauss , Ashok Tehim
IPC: A61K31/4162 , A61K31/425 , A61K31/46 , A61K31/4745 , C07D471/02 , C07D487/08 , C07D487/18
CPC classification number: C07D487/08
Abstract: The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nAChR), activation of nAChRs, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds for example, indoles, 1H-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, which act as ligands for the α7 nAChR subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.
Abstract translation: 本发明一般涉及烟碱乙酰胆碱受体（nAChR）的配体领域，nAChR的活化以及与缺陷或功能不良的烟碱乙酰胆碱受体，特别是脑的疾病相关的疾病状况的治疗。 此外，本发明涉及例如吲哚，1H-吲唑，1,2-苯并异恶唑和1,2-苯并异噻唑的新化合物，其作为α7nAChR亚型的配体，制备这些化合物的方法，含有这些化合物的组合物 ，及其使用方法。
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10.发明申请INDAZOLES, BENZOTHIAZOLES, AND BENZOISOTHIAZOLES, AND PREPARATION AND USES THEREOF 失效伊佐唑，苯并噻唑和苯并噻唑及其制备及用途公开(公告)号：US20110212957A1
公开(公告)日：2011-09-01
申请号：US13103512
申请日：2011-05-09
Applicant: Wenge Xie , Brian Herbert , Truc Nguyen , Carla Gauss , Ashok Tehim
Inventor： Wenge Xie , Brian Herbert , Truc Nguyen , Carla Gauss , Ashok Tehim
IPC: A61K31/5377 , C07D453/02 , A61K31/439 , A61P25/18 , A61P25/00 , A61P25/28
CPC classification number: C07D453/02
Abstract: The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nAChR), activation of nAChRs, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds (indazoles and benzothiazoles), which act as ligands for the α7 nAChR subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.
Abstract translation: 本发明一般涉及烟碱乙酰胆碱受体（nAChR）的配体领域，nAChR的活化以及与缺陷或功能不良的烟碱乙酰胆碱受体，特别是脑的疾病相关的疾病状况的治疗。 此外，本发明涉及作为α7nAChR亚型的配体的新化合物（吲唑和苯并噻唑），制备这些化合物的方法，含有这些化合物的组合物及其使用方法。
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