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1.发明授权公开(公告)号：US08956813B2
公开(公告)日：2015-02-17
申请号：US12739193
申请日：2008-09-23
Applicant: Johann Mertens , Francisco Javier Tamayo De Miguel , Montserrat Calleja Gomez , Daniel Vega Ramos , Celia Rogero Blanco , Jose Angel Martin Gago , Carlos Briones Llorente
Inventor： Johann Mertens , Francisco Javier Tamayo De Miguel , Montserrat Calleja Gomez , Daniel Vega Ramos , Celia Rogero Blanco , Jose Angel Martin Gago , Carlos Briones Llorente
CPC classification number: G01N33/54373 , B82Y35/00
Abstract: The present invention refers to a method for detecting molecules and/or substances within a sample based on the use of a microcantilever system. The method comprises the variation of a certain condition such as humidity so as the mechanical feature analyzed varies with a characteristic pattern while the target molecule is bound to the detector. The invention also refers to the system used to carry out such method.
Abstract translation: 本发明涉及一种基于使用微悬臂梁系统检测样品内的分子和/或物质的方法。 该方法包括一些条件如湿度的变化，以便分析的机械特征随着特征图案而变化，而目标分子与检测器结合。 本发明还涉及用于执行这种方法的系统。
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Patent Agency Ranking
公开(公告)号：US20130040292A1
公开(公告)日：2013-02-14
申请号：US12067166
申请日：2006-09-12
Applicant: Victor Manuel Fernandez Lopez , Jose Angel Martin Gago , Marcos Pita Martinez , Jose Carlos Serna Pereda , Carlos Briones Llorente , Cristina Vaz Dominguez , Eva Mateo Marti
Inventor： Victor Manuel Fernandez Lopez , Jose Angel Martin Gago , Marcos Pita Martinez , Jose Carlos Serna Pereda , Carlos Briones Llorente , Cristina Vaz Dominguez , Eva Mateo Marti
CPC classification number: G01N33/54326 , B01J2219/005 , B01J2219/00576 , B01J2219/00722 , B01J2219/00729 , B82Y15/00 , B82Y30/00 , G01N2446/20
Abstract: The invention relates to the field of biosensors and, more specifically, to nanoparticle biosensors comprising: a magnetic core, a silica layer, one or more outer metal layers which can be of different types and deposited in an alternating manner and immobilized on the outer surface, and a layer of synthetic or natural organic or inorganic biosensor molecules that can bind to biomolecules. The invention also relates to a method of obtaining the nanoparticle biosensors as well as to the different uses thereof.
Abstract translation: 本发明涉及生物传感器领域，更具体地涉及纳米颗粒生物传感器，其包括：磁芯，二氧化硅层，一个或多个外部金属层，其可以是不同类型并以交替方式沉积并固定在外表面上 以及可以结合生物分子的合成或天然有机或无机生物传感器分子层。 本发明还涉及获得纳米颗粒生物传感器的方法及其不同用途。
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3.发明申请公开(公告)号：US20110039255A1
公开(公告)日：2011-02-17
申请号：US12739193
申请日：2008-09-23
Applicant: Johann Mertens , Francisco Javier Tamayo De Miguel , Montserrat Calleja Gómez , Daniel Vega Ramos , Celia Rogero Blanco , José Angel Martín Gago , Carlos Briones Llorente
Inventor： Johann Mertens , Francisco Javier Tamayo De Miguel , Montserrat Calleja Gómez , Daniel Vega Ramos , Celia Rogero Blanco , José Angel Martín Gago , Carlos Briones Llorente
CPC classification number: G01N33/54373 , B82Y35/00
Abstract: The present invention refers to a method for detecting molecules and/or substances within a sample based on the use of a microcantilever system. The method comprises the variation of a certain condition such as humidity so as the mechanical feature analysed varies with a characteristic pattern while the target molecule is bound to the detector. The invention also refers to the system used to carry out such method.
Abstract translation: 本发明涉及一种基于使用微悬臂梁系统检测样品内的分子和/或物质的方法。 该方法包括一些条件如湿度的变化，以便分析的机械特征随着特征图案而变化，而目标分子与检测器结合。 本发明还涉及用于执行这种方法的系统。
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4.发明授权Method and apparatus for detecting substances or analytes from the analysis of one or more samples 有权从一个或多个样品的分析中检测物质或分析物的方法和装置公开(公告)号：US08097209B2
公开(公告)日：2012-01-17
申请号：US10558936
申请日：2004-05-28
Applicant: Javier Gómez-Elvira Rodríguez , Eduardo Sebastián Martínez , Carlos Briones Llorente , Victor Parro García , José Antonio Rodríguez Manfredi , Carlos Compostizo Sañudo , Pedro Luis Herrero Gonzalo , Juan Pérez Mercader
Inventor： Javier Gómez-Elvira Rodríguez , Eduardo Sebastián Martínez , Carlos Briones Llorente , Victor Parro García , José Antonio Rodríguez Manfredi , Carlos Compostizo Sañudo , Pedro Luis Herrero Gonzalo , Juan Pérez Mercader
IPC: C12Q1/68
CPC classification number: G01N1/31 , G01N2001/2866
Abstract: The invention relates to a method and apparatus for detecting substances or analytes form the analysis of one or several samples. The method comprises mixing the sample with a suitable liquid buffer, homogenizing said sample, adding reagents thereto, filtering it, injecting the sample into the incubation chamber, allowing the sample to react with a biosensor, washing the non-reacted sample excess and detecting the sample retained in the biosensor. The apparatus includes a sample homogenizer module with an ultrasonic piezoelectric device formed by a converter (49) and a horn (16); a sample processing module including a homogenization container (6) and a moving frame (17); a reagent and solution management module including a motorized syringe (60), a reaction module consisting of a support (50) forming a reaction chamber (51) and a data reading module including a laser diode (66) and a CCD camera (67).
Abstract translation: 本发明涉及从一个或几个样品的分析中检测物质或分析物的方法和装置。 该方法包括将样品与合适的液体缓冲液混合，均化所述样品，向其中加入试剂，过滤，将样品注入孵育室，使样品与生物传感器反应，洗涤未反应的样品过量并检测 样品保留在生物传感器中。 该装置包括具有由转换器（49）和喇叭（16）形成的超声波压电装置的样品均化器模块; 包括均质容器（6）和移动框架（17）的样品处理模块; 包括电动注射器（60）的试剂和溶液管理模块，由形成反应室（51）的支撑件（50）和包括激光二极管（66）和CCD照相机（67）的数据读取模块组成的反应模块， 。
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5.发明申请Method and apparatus for detecting substances or analytes from the analysis of one or more samples 有权从一个或多个样品的分析中检测物质或分析物的方法和装置公开(公告)号：US20070099189A1
公开(公告)日：2007-05-03
申请号：US10558936
申请日：2004-05-28
Applicant: Javier Gomez-Elvira Rodriguez , Eduardo Sebastian Martinez , Carlos Briones Llorente , Victor Parro Garcia , Jose Rodriguez Manfredi , Carlos Compostizo Sanudo , Pedro Herrero Gonzalo , Juan Perez Mercader
Inventor： Javier Gomez-Elvira Rodriguez , Eduardo Sebastian Martinez , Carlos Briones Llorente , Victor Parro Garcia , Jose Rodriguez Manfredi , Carlos Compostizo Sanudo , Pedro Herrero Gonzalo , Juan Perez Mercader
CPC classification number: G01N1/31 , G01N2001/2866
Abstract: The invention relates to a method and apparatus for detecting substances or analytes form the analysis of one or several samples. The method comprises mixing the sample with a suitable liquid buffer, homogenizing said sample, adding reagents thereto, filtering it, injecting the sample into the incubation chamber, allowing the sample to react with a biosensor, washing the non-reacted sample excess and detecting the sample retained in the biosensor. The apparatus includes a sample homogenizer module with an ultrasonic piezoelectric device formed by a converter (49) and a horn (16); a sample processing module including a homogenization container (6) and a moving frame (17); a reagent and solution management module including a motorized syringe (60), a reaction module consisting of a support (50) forming a reaction chamber (51) and a data reading module including a laser diode (66) and a CCD camera (67).
Abstract translation: 本发明涉及从一个或几个样品的分析中检测物质或分析物的方法和装置。 该方法包括将样品与合适的液体缓冲液混合，均化所述样品，向其中加入试剂，过滤，将样品注入孵育室，使样品与生物传感器反应，洗涤未反应的样品过量并检测 样品保留在生物传感器中。 该装置包括具有由转换器（49）和喇叭（16）形成的超声波压电装置的样品均化器模块; 包括均质容器（6）和移动框架（17）的样品处理模块; 包括电动注射器（60）的试剂和溶液管理模块，由形成反应室（51）的支撑件（50）和包括激光二极管（66）和CCD照相机（67）的数据读取模块组成的反应模块， 。
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公开(公告)号：US08623636B2
公开(公告)日：2014-01-07
申请号：US12067166
申请日：2006-09-12
Applicant: Victor Manuel Fernandez Lopez , Jose Angel Martin Gago , Marcos Pita Martinez , Jose Carlos Serna Pereda , Carlos Briones Llorente , Cristina Vaz Dominguez , Eva Mateo Marti
Inventor： Victor Manuel Fernandez Lopez , Jose Angel Martin Gago , Marcos Pita Martinez , Jose Carlos Serna Pereda , Carlos Briones Llorente , Cristina Vaz Dominguez , Eva Mateo Marti
IPC: C12Q1/68 , C12M1/34 , B05D7/00 , G01N33/553
CPC classification number: G01N33/54326 , B01J2219/005 , B01J2219/00576 , B01J2219/00722 , B01J2219/00729 , B82Y15/00 , B82Y30/00 , G01N2446/20
Abstract: The invention relates to the field of biosensors and, more specifically, to nanoparticle biosensors comprising: a magnetic core, a silica layer, one or more outer metal layers which can be of different types and deposited in an alternating manner and immobilized on the outer surface, and a layer of synthetic or natural organic or inorganic biosensor molecules that can bind to biomolecules. The invention also relates to a method of obtaining the nanoparticle biosensors as well as to the different uses thereof.
Abstract translation: 本发明涉及生物传感器领域，更具体地涉及纳米颗粒生物传感器，其包括：磁芯，二氧化硅层，一个或多个外部金属层，其可以是不同类型并以交替方式沉积并固定在外表面上 以及可以结合生物分子的合成或天然有机或无机生物传感器分子层。 本发明还涉及获得纳米颗粒生物传感器的方法及其不同用途。
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