公开(公告)号：US5419874A

公开(公告)日：1995-05-30

申请号：US909552

申请日：1992-07-06

申请人： Peter J. Coassin ,  Edward G. Hanna ,  Carlton B. Mc Kinney ,  Jang B. Rampal ,  Glenn C. Sasaki ,  Stephen W. Wunderly

发明人： Peter J. Coassin ,  Edward G. Hanna ,  Carlton B. Mc Kinney ,  Jang B. Rampal ,  Glenn C. Sasaki ,  Stephen W. Wunderly

IPC分类号： C07H21/04 ,  B01J19/00 ,  B01L1/00 ,  B01L3/00 ,  C07H21/00 ,  C07K1/04 ,  C40B40/06 ,  C40B50/14 ,  C40B60/14 ,  C08F8/00

CPC分类号： C07H21/00 ,  B01J19/0046 ,  B01L3/502 ,  C07K1/045 ,  B01J2219/00286 ,  B01J2219/00292 ,  B01J2219/00335 ,  B01J2219/00373 ,  B01J2219/00454 ,  B01J2219/005 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00686 ,  B01J2219/00722 ,  C40B40/06 ,  C40B50/14 ,  C40B60/14

摘要： The present invention is directed to a synthesis reaction column which can be conveniently implemented in post synthesis procedures. The reaction column is configured to allow easy connection to a syringe and post synthesis reagent container without requiring connection adapters.In one embodiment, the reaction column configured in the form of a cylindrical column containing the solid-phase support and having a narrow bore tube extending at one end. The tube functions as a piercing tip for accessing a septum sealed vial containing post synthesis reagent. In another embodiment, the reaction column is configured in the form of a cylindrical barrel enclosing the solid-phase support and having a threaded mount at one end. To complement the reaction column for post synthesis procedures, a vial having a complementary threaded mount at the opening is used for containing a reagent. This vial is conveniently threaded onto the end of the barrel without adapters. Consequently, post synthesis procedures can be implemented conveniently. Both embodiments may be conveniently connected to the reagent delivery system in an automated instrument for carrying out synthesis procedures, as well as post synthesis procedures.

摘要翻译： 本发明涉及一种合成反应塔，其可以在后合成方法中方便地实施。 反应塔被配置为允许容易地连接到注射器和后合成试剂容器而不需要连接适配器。 在一个实施方案中，反应塔以包含固相载体并且在一端延伸的窄孔管的圆柱形柱形式构成。 该管用作用于进入含有后合成试剂的隔膜密封小瓶的穿刺尖端。 在另一个实施方案中，反应塔被配置成包围固相载体并在一端具有螺纹安装座的圆柱形筒形式。 为了补充后合成方法的反应塔，在开口处具有互补螺纹安装座的小瓶被用于容纳试剂。 该小瓶方便地拧到筒的端部，而没有适配器。 因此，可以方便地实现后合成程序。 两个实施方案可以方便地连接到用于进行合成过程的自动化仪器中的试剂递送系统以及后合成程序。