公开(公告)号：US20160339439A1

公开(公告)日：2016-11-24

申请号：US15159026

申请日：2016-05-19

Applicant: Mitsubishi Rayon Co., Ltd.

Inventor： Kouji SHIMIZU

IPC: B01L9/00 ,  B01J19/00

CPC classification number: B01L9/523 ,  B01J19/0046 ,  B01J2219/00313 ,  B01J2219/00317 ,  B01J2219/00373 ,  B01J2219/00414 ,  B01J2219/00533 ,  B01J2219/00585 ,  B01J2219/00716 ,  B01J2219/00722 ,  B01L2200/025 ,  B01L2300/0829 ,  G01N35/028 ,  G01N35/1011 ,  G01N2035/0437

Abstract: Provided is a microarray processing apparatus which is capable of sufficiently washing a microarray. The microarray processing apparatus (30) includes a well plate (38) in which one or two or more wells (40) are formed, each well (40) accommodating a microarray (1), and a suction nozzle (46) that suctions a liquid from the well. The well has a concave portion whose upper end is opened, which has a depth equal to or greater than a height of the microarray, and into which a front end of the suction nozzle can be inserted up to a height position of a lower end of the microarray accommodated in the well. The suction nozzle can relatively descend in the well until the front end of the suction nozzle is located at the height position of the lower end of the microarray accommodated in the well.

Abstract translation: 提供一种能够充分洗涤微阵列的微阵列处理装置。 微阵列处理装置（30）包括其中形成有一个或两个以上的孔（40）的孔板（38），容纳微阵列（1）的每个孔（40）和吸入喷嘴 液体从井。 井具有上端开口的凹部，其深度等于或大于微阵列的高度，并且吸嘴的前端可以插入其中，直到下端的高度位置 微阵列容纳在井中。 吸嘴可以在井中相对下降，直到吸嘴的前端位于容纳在井中的微阵列的下端的高度位置。

公开(公告)号：US09375696B2

公开(公告)日：2016-06-28

申请号：US14371590

申请日：2013-04-04

Applicant: Mitsubishi Rayon Co., Ltd.

Inventor： Kouji Shimizu

IPC: B01L9/00 ,  B01L99/00 ,  B01J19/00 ,  G01N35/02 ,  G01N35/10 ,  G01N35/04

CPC classification number: B01L9/523 ,  B01J19/0046 ,  B01J2219/00313 ,  B01J2219/00317 ,  B01J2219/00373 ,  B01J2219/00414 ,  B01J2219/00533 ,  B01J2219/00585 ,  B01J2219/00716 ,  B01J2219/00722 ,  B01L2200/025 ,  B01L2300/0829 ,  G01N35/028 ,  G01N35/1011 ,  G01N2035/0437

Abstract: Provided is a microarray processing apparatus which is capable of sufficiently washing a microarray. The microarray processing apparatus (30) includes a well plate (38) in which one or two or more wells (40) are formed, each well (40) accommodating a microarray (1), and a suction nozzle (46) that suctions a liquid from the well. The well has a concave portion whose upper end is opened, which has a depth equal to or greater than a height of the microarray, and into which a front end of the suction nozzle can be inserted up to a height position of a lower end of the microarray accommodated in the well. The suction nozzle can relatively descend in the well until the front end of the suction nozzle is located at the height position of the lower end of the microarray accommodated in the well.

Abstract translation: 提供一种能够充分洗涤微阵列的微阵列处理装置。 微阵列处理装置（30）包括其中形成有一个或两个以上的孔（40）的孔板（38），容纳微阵列（1）的每个孔（40）和吸入喷嘴 液体从井。 井具有上端开口的凹部，其深度等于或大于微阵列的高度，并且吸嘴的前端可以插入其中，直到下端的高度位置 微阵列容纳在井中。 吸嘴可以在井中相对下降，直到吸嘴的前端位于容纳在井中的微阵列的下端的高度位置。

公开(公告)号：US20160076977A1

公开(公告)日：2016-03-17

申请号：US14888021

申请日：2013-09-18

Applicant: FREESLATE, INC.

Inventor： Stephen Lambert ,  John F. Varni ,  Gregor Hsiao

IPC: G01N1/10

CPC classification number: G01N1/10 ,  B01F13/0836 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00373 ,  B01J2219/00376 ,  B01J2219/00389 ,  B01J2219/00481 ,  C40B60/12 ,  C40B60/14 ,  G01N35/10 ,  G01N2001/105 ,  G01N2013/006

Abstract: Methods for sampling reactor contents in parallel reactor systems are disclosed. The methods may be used to sample reactor contents in non-atmospheric (e.g., pressurized) reaction vessels.

Abstract translation: 公开了在并联反应器系统中对反应器内容物进行取样的方法。 该方法可用于在非大气压（例如加压）的反应容器中对反应器内容物进行取样。

公开(公告)号：US08937174B2

公开(公告)日：2015-01-20

申请号：US12864641

申请日：2009-01-13

Applicant: Thomas Rothmann ,  Ralf Himmelreich ,  Thomas Laue

Inventor： Thomas Rothmann ,  Ralf Himmelreich ,  Thomas Laue

IPC: C07H21/00 ,  C12Q1/68 ,  C12M1/00 ,  B01L3/00 ,  B01L7/00

CPC classification number: B01L3/502715 ,  B01J2219/00335 ,  B01J2219/00373 ,  B01J2219/00423 ,  B01J2219/00605 ,  B01J2219/00641 ,  B01J2219/00722 ,  B01L7/52 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/10 ,  B01L2300/0672 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/1827 ,  C12M47/06

Abstract: The invention relates to a method and a device for the automatic processing of biological samples which can have a relatively large volume and which can be further processed by a microfluidic system. A container is provided with a filter and can be or is closed. A biological sample is introduced into the container. An inlet or outlet for liquids is mounted downstream of the filter. In order to carry out processing, liquids that are present in the container are not only sucked off through the filter and passed on via the inlet or outlet, but liquids required for processing are also pumped into the container through the filter. The container can be connected to a microfluidic system in a relatively easy manner since only one conduit is required for an automated processing.

Abstract translation: 本发明涉及一种用于自动处理生物样品的方法和装置，其可以具有相对较大的体积并且可以由微流体系统进一步处理。 容器设有过滤器，可以被关闭。 将生物样品引入容器中。 用于液体的入口或出口安装在过滤器的下游。 为了进行处理，存在于容器中的液体不仅通过过滤器吸出并经由入口或出口通过，而且处理所需的液体也通过过滤器被泵送到容器中。 容器可以以相对容易的方式连接到微流体系统，因为仅需要一个管道用于自动化处理。

公开(公告)号：US20120252132A1

公开(公告)日：2012-10-04

申请号：US13484358

申请日：2012-05-31

Applicant: Hideji Tajima

Inventor： Hideji Tajima

IPC: G01N21/64 ,  B01L3/00

CPC classification number: C12Q1/6804 ,  B01J2219/00292 ,  B01J2219/00364 ,  B01J2219/00373 ,  B01J2219/005 ,  B01J2219/0052 ,  B01J2219/00545 ,  B01J2219/00576 ,  B01J2219/00596 ,  B01L3/0275 ,  B01L3/502 ,  B01L2200/0647 ,  B01L2300/0636 ,  B01L2300/0838 ,  B01L2300/1827 ,  G01N30/6047 ,  G01N30/6052 ,  G01N30/6073 ,  G01N33/54313 ,  G01N35/10 ,  G01N2035/00564 ,  G01N2035/00574 ,  G01N2035/1055 ,  Y10T436/11

Abstract: A various-substance holder, a various-substance holder treating apparatus, and a various-substance holder treating method are provided which enable the mutual identification of particulate carriers to which various substances are or can be immobilized without the need to arrange the particulate carriers at predetermined positions or in a predetermined order, eliminating the need for time and effort to arrange the various substances at predetermined positions or in a predetermined order to allow treatments to be quickly and easily achieved. The various-substance holder has a plurality of particulate carriers or plural sets of particulate carriers to which plural types of chemical substances are or can be immobilized and a carrier holding portion holding the plurality of particulate carriers or the plural sets of particulate carriers in a substantially stationary state such that the plurality of particulate carriers or the plural sets of particulate carriers can be externally measured.

Abstract translation: 提供了各种物质保持器，各种物质保持器处理装置和各种物质保持器处理方法，其能够相互识别各种物质可固定或可固定的颗粒载体，而无需将颗粒载体置于 预定位置或以预定顺序，消除了对各种物质在预定位置或以预定顺序排列的时间和精力的需要，以便快速且容易地实现治疗。 各种物质保持器具有多个颗粒状载体或多组微粒载体，多种化学物质被固定在其上，并且载体保持部分将多个颗粒载体或多组微粒载体保持在基本上 使得可以外部测量多个颗粒载体或多组颗粒载体。

公开(公告)号：US20060133968A1

公开(公告)日：2006-06-22

申请号：US11272249

申请日：2005-11-10

Applicant: G. Dales ,  Johannes van Beek ,  Damian Hajduk ,  Ralph Nielsen ,  Paul Mansky ,  Leonid Matsiev ,  Eric McFarland

Inventor： G. Dales ,  Johannes van Beek ,  Damian Hajduk ,  Ralph Nielsen ,  Paul Mansky ,  Leonid Matsiev ,  Eric McFarland

IPC: B01J19/00

CPC classification number: B01L3/50851 ,  B01F13/0818 ,  B01F13/0827 ,  B01F15/00201 ,  B01F15/00207 ,  B01F15/00246 ,  B01J19/0006 ,  B01J19/0013 ,  B01J19/004 ,  B01J19/0046 ,  B01J2219/00029 ,  B01J2219/00162 ,  B01J2219/002 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00333 ,  B01J2219/00335 ,  B01J2219/00351 ,  B01J2219/00367 ,  B01J2219/00373 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00601 ,  B01J2219/00686 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00736 ,  B01J2219/00738 ,  B01J2219/00745 ,  B01L3/50853 ,  B01L7/54 ,  B01L2200/026 ,  B01L2300/049 ,  B01L2300/06 ,  B01L2300/0627 ,  B01L2300/14 ,  B01L2300/1805 ,  C40B40/14 ,  C40B40/18 ,  G01K13/00 ,  G01N11/16 ,  G01N35/1079 ,  Y10T436/11 ,  Y10T436/115831 ,  Y10T436/119163 ,  Y10T436/12 ,  Y10T436/25 ,  Y10T436/25875

Abstract: Devices and methods for controlling and monitoring the progress and properties of multiple reactions are disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight. Computer-based methods are disclosed for process monitoring and control, and for data display and analysis.

公开(公告)号：US20060117869A1

公开(公告)日：2006-06-08

申请号：US11241297

申请日：2005-09-30

Applicant: Thomas Brinz ,  Jane Lewis ,  Markus Tiefenbacher ,  Thomas Geiger

Inventor： Thomas Brinz ,  Jane Lewis ,  Markus Tiefenbacher ,  Thomas Geiger

IPC: G01D7/00

CPC classification number: B01L3/0217 ,  B01J2219/00373 ,  B01J2219/0038 ,  B01L2200/0657 ,  B01L2200/141 ,  B65B1/38 ,  G01F11/003 ,  G01F11/027 ,  G01F11/10

Abstract: A method for metering powders as well as a powder metering device are described which are used in particular for preparing combinatorial material libraries. The powder metering device includes a metering element having a tubular supply vessel open on one end for taking up the powder to be metered and a plunger which is axially movable and which reversibly closes the end of the tubular supply vessel opposite the opening. To take up the powder, the opening of the metering element is first plunged with a predetermined force into a loose fill of the powder to be metered previously charged in a metering receiver.

Abstract translation: 描述了用于计量粉末的方法以及粉末计量装置，其特别用于制备组合材料库。 粉末计量装置包括计量元件，该计量元件具有在一端开口用于吸收要计量的粉末的管状供应容器和可轴向移动并且可逆地封闭与开口相对的管状供应容器的端部的柱塞。 为了吸收粉末，首先将计量元件的开口以预定的力冲入到预先装入计量接收器中的要计量的粉末的松散填充物中。

公开(公告)号：US20050166782A2

公开(公告)日：2005-08-04

申请号：US10490519

申请日：2004-03-23

Applicant: Yoshihide Hayashizaki

Inventor： Yoshihide Hayashizaki

IPC: B42D11/00 ,  B01J19/00 ,  B42D15/00 ,  C07B61/00 ,  C07K14/59 ,  C12N15/00 ,  C12N15/09 ,  B41F1/00

CPC classification number: B01J19/0046 ,  B01J2219/00373 ,  B01J2219/00378 ,  B01J2219/00387 ,  B01J2219/00527 ,  B01J2219/00547 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00637 ,  B01J2219/00641 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00729 ,  B01J2219/00731 ,  B42D15/0086 ,  C07B2200/11 ,  C07K14/59 ,  C40B40/00

Abstract: Abstract of the DisclosureA printed material comprising at least one support having at least one oligomer and/or polymer applied thereon is provided. Also, a method for preparing the printed material and a method for delivering and storing at least one oligomer and/or polymer are provided. The printed materials of the present invention are useful in providing scientists with oligomers and/or polymers of interest from the printed materials easily and immediately.

Abstract translation: 公开摘要提供了包含至少一种具有至少一种低聚物和/或聚合物的载体的印刷材料。 此外，提供了制备印刷材料的方法和用于递送和存储至少一种低聚物和/或聚合物的方法。 本发明的印刷材料可用于向科学家提供易于且立即从印刷材料的感兴趣的低聚物和/或聚合物。

公开(公告)号：US06890492B1

公开(公告)日：2005-05-10

申请号：US09724276

申请日：2000-11-28

Applicant: Howard Turner ,  G. Cameron Dales ,  Lynn VanErden ,  Johannes A. M. Van Beek ,  Damian A. Hajduk ,  Ralph B. Nielsen ,  Paul Mansky ,  Leonid Matsiev ,  Pei Wang ,  Eric McFarland

Inventor： Howard Turner ,  G. Cameron Dales ,  Lynn VanErden ,  Johannes A. M. Van Beek ,  Damian A. Hajduk ,  Ralph B. Nielsen ,  Paul Mansky ,  Leonid Matsiev ,  Pei Wang ,  Eric McFarland

IPC: B01F15/00 ,  B01J19/00 ,  B01L3/00 ,  B01L7/00 ,  C40B40/14 ,  C40B40/18 ,  G01K13/00 ,  G01N11/16 ,  G01N35/10 ,  B01F7/00

CPC classification number: B01L3/50851 ,  B01F13/0818 ,  B01F13/0827 ,  B01F15/00201 ,  B01F15/00207 ,  B01F15/00246 ,  B01J19/0006 ,  B01J19/0013 ,  B01J19/004 ,  B01J19/0046 ,  B01J2219/00029 ,  B01J2219/00162 ,  B01J2219/002 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00333 ,  B01J2219/00335 ,  B01J2219/00351 ,  B01J2219/00367 ,  B01J2219/00373 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00601 ,  B01J2219/00686 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00736 ,  B01J2219/00738 ,  B01J2219/00745 ,  B01L3/50853 ,  B01L7/54 ,  B01L2200/026 ,  B01L2300/049 ,  B01L2300/06 ,  B01L2300/0627 ,  B01L2300/14 ,  B01L2300/1805 ,  C40B40/14 ,  C40B40/18 ,  G01K13/00 ,  G01N11/16 ,  G01N35/1079 ,  Y10T436/11 ,  Y10T436/115831 ,  Y10T436/119163 ,  Y10T436/12 ,  Y10T436/25 ,  Y10T436/25875

Abstract: Devices and methods for controlling and monitoring the progress and properties of multiple reactions are disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight. Computer-based methods are disclosed for process monitoring and control, and for data display and analysis.

Abstract translation: 公开了用于控制和监测多个反应的进展和性质的装置和方法。 该方法和装置对于组合文库的合成，筛选和表征特别有用，但是与常规实验反应器相比也具有显着的优点。 该装置通常包括用于容纳反应混合物的多个容器和用于控制各个反应混合物或反应混合物组的搅拌速率和温度的系统。 此外，该装置可以包括用于独立地控制每个容器中的压力的​​装置，以及用于以不同于环境压力的压力将液体注入容器的系统。 单独反应混合物的原位监测为过程控制器提供反馈，并提供了确定反应速率，产物产率和反应产物各种性质（包括粘度和分子量）的数据。 公开了基于计算机的方法，用于过程监控和控制，以及数据显示和分析。

公开(公告)号：US20030124028A1

公开(公告)日：2003-07-03

申请号：US10156222

申请日：2002-05-24

Inventor： Eric D. Carlson ,  Peijun Cong ,  William H. Chandler JR. ,  Henry K. Chau ,  Earl Danielson ,  Peter J. Desrosiers ,  Robert D. Doolen ,  Luping Wu ,  C. Eric Ramberg ,  Thomas Crevier ,  Ralph B. Nielsen ,  Colin S. Masui ,  John F. Varni

IPC: G01N021/47 ,  G01N033/00

CPC classification number: B01L3/50255 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/00315 ,  B01J2219/00335 ,  B01J2219/00364 ,  B01J2219/00373 ,  B01J2219/00423 ,  B01J2219/00481 ,  B01J2219/00484 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00689 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/00725 ,  B01J2219/00756 ,  B01L3/06 ,  B01L7/00 ,  B01L2300/0829 ,  B01L2300/185 ,  C40B40/04 ,  C40B40/10 ,  C40B60/10 ,  C40B60/14 ,  G01N5/045 ,  G01N21/23 ,  G01N21/65 ,  G01N25/04 ,  G01N33/15 ,  G01N33/54366 ,  G01N35/028 ,  G01N2013/006 ,  G01N2021/651 ,  G01N2500/00 ,  G16C20/20 ,  G16C20/90 ,  Y10T117/10

Abstract: The invention provides methods, apparatus, and systems for performing high-throughput preparation and screening of salts and polymorphs of drug candidates. The invention is directed towards enhancing the pre-formulation discovery process used for drug development. In particular, processes that determine suitable salts and processes that discover substantially every polymorph that can form from a particular drug candidate are provided. The processes are performed using several apparatuses that are specifically configured to carry-out various steps in a high-throughput characterization process. One such apparatus is configured for synthesizing a plurality of library members based on, for example, a library model generated by a computer system. Another apparatus may filter the synthesized solution to provide a substantially pure mixture that can be subjected to salt or polymorph testing. Yet another apparatus may be used to crystallize mixtures on a substrate such that the crystallized mixture can be screened by one or more screening devices.

Abstract translation: 本发明提供了用于进行候选药物的盐和多晶型物的高通量制备和筛选的方法，装置和系统。 本发明旨在增强用于药物开发的预配制发现过程。 特别地，提供了确定基本上发现可从特定药物候选物形成的每个多晶型物的合适的盐和方法的方法。 使用特定配置为在高吞吐量表征过程中执行各种步骤的几个装置来执行处理。 一种这样的装置被配置为基于例如由计算机系统生成的库模型来合成多个库成员。 另一种装置可以过滤合成的溶液以提供可以进行盐或多晶型测试的基本上纯的混合物。 可以使用另一种装置将混合物在基底上结晶，使得结晶的混合物可以被一个或多个筛选装置筛选。