公开(公告)号：US20200254002A1

公开(公告)日：2020-08-13

申请号：US16649320

申请日：2018-09-28

申请人： SAREPTA THERAPEUTICS, INC. ,  CATABASIS PHARMACEUTICALS, INC.

发明人： Marco A. PASSINI ,  Jill C. MILNE ,  Andrew J. NICHOLS

IPC分类号： A61K31/7125 ,  A61P21/00

摘要： The present disclosure relates to methods of treating Duchenne's Muscular Dystrophy by administering an antisense oligonucleotide that induces exon skipping and a non-steroidal anti-inflammatory compound.

公开(公告)号：US20170246193A1

公开(公告)日：2017-08-31

申请号：US15283995

申请日：2016-10-03

申请人： Catabasis Pharmaceuticals, Inc.

发明人： Jill C. Milne ,  Michael R. Jirousek ,  Jean E. Bemis ,  Jesse J. Smith

IPC分类号： A61K31/609

CPC分类号： A61K31/609 ,  A61K31/60 ,  C07C69/86 ,  C07C69/94 ,  C07C233/18 ,  C07C233/49 ,  C07C233/55 ,  C07C235/52 ,  C07C235/60 ,  C07C237/22 ,  C07C271/28 ,  C07C275/42 ,  C07D295/182 ,  C07D295/192

摘要： The invention relates to Fatty Acid Acetylated Salicylate Derivatives; compositions comprising an effective amount of a Fatty Acid Acetylated Salicylate Derivative; and methods for treating or preventing an inflammatory disorder comprising the administration of an effective amount of a Fatty Acid Acetylated Salicylate Derivative.

公开(公告)号：US20170073305A1

公开(公告)日：2017-03-16

申请号：US15243334

申请日：2016-08-22

申请人： Catabasis Pharmaceuticals, Inc.

发明人： Jill C. Milne ,  Michael R. Jirousek ,  Jean E. Bemis ,  Chi B. Vu ,  Amal Ting

IPC分类号： C07C323/41

CPC分类号： C07C323/41 ,  A61K45/06 ,  C07C233/20 ,  C07H13/04

摘要： The invention relates to fatty acid amides; compositions comprising an effective amount of a fatty acid amide; and methods for treating or preventing cancer, a metabolic disease or a neurodegenerative disease comprising the administration of an effective amount of a fatty acid amide.

摘要翻译： 本发明涉及脂肪酸酰胺; 包含有效量的脂肪酸酰胺的组合物; 以及用于治疗或预防癌症，代谢疾病或神经变性疾病的方法，其包括施用有效量的脂肪酸酰胺。

公开(公告)号：US09272984B2

公开(公告)日：2016-03-01

申请号：US14251257

申请日：2014-04-11

申请人： Catabasis Pharmaceuticals, Inc.

发明人： Jill C. Milne ,  Michael R. Jirousek ,  Jean E. Bemis ,  Jesse J. Smith

IPC分类号： C07C233/55 ,  C07C69/86 ,  C07C69/94 ,  C07C233/18 ,  C07C233/49 ,  C07C235/60 ,  C07C237/22 ,  C07C271/28 ,  C07C275/42 ,  C07D295/182 ,  C07D295/192 ,  C07C235/52 ,  A61K31/60

CPC分类号： A61K31/609 ,  A61K31/60 ,  C07C69/86 ,  C07C69/94 ,  C07C233/18 ,  C07C233/49 ,  C07C233/55 ,  C07C235/52 ,  C07C235/60 ,  C07C237/22 ,  C07C271/28 ,  C07C275/42 ,  C07D295/182 ,  C07D295/192

摘要： The invention relates to Fatty Acid Acetylated Salicylate Derivatives; compositions comprising an effective amount of a Fatty Acid Acetylated Salicylate Derivative; and methods for treating or preventing an inflammatory disorder comprising the administration of an effective amount of a Fatty Acid Acetylated Salicylate Derivative.

公开(公告)号：US20150238618A1

公开(公告)日：2015-08-27

申请号：US14635567

申请日：2015-03-02

申请人： Catabasis Pharmaceuticals, Inc.

发明人： Jill C. Milne ,  Michael R. Jirousek ,  Jean E. Bemis ,  Chi B. Vu

IPC分类号： A61K47/48 ,  A61K31/385 ,  A61K31/495 ,  A61K31/4015 ,  A61K31/221 ,  A61K31/197

CPC分类号： C07C235/76 ,  A61K31/195 ,  A61K31/197 ,  A61K31/221 ,  A61K31/225 ,  A61K31/385 ,  A61K31/4015 ,  A61K31/495 ,  A61K47/55 ,  C07C233/20 ,  C07C233/38 ,  C07C233/49 ,  C07C323/41 ,  C07D207/14 ,  C07D207/40 ,  C07D207/416 ,  C07D241/04 ,  C07D295/18 ,  C07D339/04

摘要： The invention relates to Fatty Acid Fumarate Derivatives; compositions comprising an effective amount of a Fatty Acid Fumarate Derivative; and methods for treating or preventing cancer, a metabolic disorder or neurodegenerative disorder comprising the administration of an effective amount of a Fatty Acid Fumarate Derivative.

摘要翻译： 本发明涉及富马酸脂肪酸衍生物; 包含有效量的富马酸脂肪酸衍生物的组合物; 以及用于治疗或预防癌症，代谢紊乱或神经变性疾病的方法，包括施用有效量的富马酸脂肪酸衍生物。

公开(公告)号：US20210023029A1

公开(公告)日：2021-01-28

申请号：US16761783

申请日：2018-11-05

申请人： Catabasis Pharmaceuticals, Inc.

发明人： Andrew J. Nichols ,  Michael Perlman

IPC分类号： A61K31/166 ,  A61P21/00 ,  A61K9/48

摘要： The invention provides methods and compositions for treating a muscular dystrophy, e.g., Duchenne muscular dystrophy (DMD), in a subject, with a fatty acid acetylated salicylate, e.g., edasalonexent, effective to achieve a threshold plasma concentration of the fatty acid acetylated salicylate in the subject, e.g., a threshold plasma concentration of at least about 20 ng/ml for least 12 hours in a 24 hour period.

公开(公告)号：US10251845B2

公开(公告)日：2019-04-09

申请号：US15529316

申请日：2015-11-25

申请人： Catabasis Pharmaceuticals, Inc.

发明人： Chi B. Vu ,  Michael R. Jirousek

IPC分类号： A61K31/4406 ,  C07D213/82 ,  A61K31/105 ,  A61K31/095 ,  A61K31/121 ,  A61K31/195 ,  A61K45/06 ,  C07C323/23 ,  A61K47/54

摘要： The invention relates to (i) 6-membered heteroaryl substituted fatty acid cystamine conjugates, compositions thereof, methods of treating diseases involving dysregulation of autophagy, such as cystic fibrosis, idiopathic pulmonary fibrosis (IPF), a neurodegenerative disease, inflammatory disease, liver disease, muscle disease, infection and immune disease with this compound, or (ii) a method of treating idiopathic pulmonary fibrosis, mitochondrial diseases, Leigh Syndrome, Diabetes Mellitus and Deafness (DAD), Leber's hereditary optic neuropathy, Neuropathy-ataxia-retinis pigmentosa and ptosis (NARP), myoneurogenic gastrointestinal encephalopathy (MNGlE), myoclonic epilepsy with ragged red fibers (MERRF), or mitochondrial myopathy-encephalomy-opathy-lactic acidosis stroke like symptoms (MELAS), comprising administering to a patient the fatty acid cysteamine conjugate, (4Z, 7Z. 10Z, 13Z, 16Z, 19Z)—N-(2-mercaptoethyl) docosa-4,7,10,13,16,19-hexaenamide or (5Z, 8Z, 11Z, 14Z, 17Z)—N-(2-mercaptoethyl) icosa-5,8,11,14,17-pentaenamide.

公开(公告)号：US20180325923A1

公开(公告)日：2018-11-15

申请号：US15839346

申请日：2017-12-12

申请人： Catabasis Pharmaceuticals, Inc.

发明人： Jill C. Milne ,  Michael R. Jirousek ,  Jean E. Bemis ,  Jesse J. Smith

IPC分类号： A61K31/609 ,  C07C235/52 ,  C07D295/192 ,  C07D295/182 ,  C07C275/42 ,  C07C271/28

CPC分类号： A61K31/609 ,  A61K31/60 ,  C07C69/86 ,  C07C69/94 ,  C07C233/18 ,  C07C233/49 ,  C07C233/55 ,  C07C235/52 ,  C07C235/60 ,  C07C237/22 ,  C07C271/28 ,  C07C275/42 ,  C07D295/182 ,  C07D295/192

摘要： The invention relates to Fatty Acid Acetylated Salicylate Derivatives; compositions comprising an effective amount of a Fatty Acid Acetylated Salicylate Derivative; and methods for treating or preventing an inflammatory disorder comprising the administration of an effective amount of a Fatty Acid Acetylated Salicylate Derivative.

公开(公告)号：US20160106712A1

公开(公告)日：2016-04-21

申请号：US14977006

申请日：2015-12-21

申请人： Catabasis Pharmaceuticals, Inc.

发明人： Jill C. Milne ,  Michael R. Jirousek ,  Jean E. Bemis ,  Chi B. Vu

IPC分类号： A61K31/405 ,  A61K31/165

CPC分类号： A61K31/405 ,  A61K31/165 ,  A61K47/542 ,  A61K47/55

摘要： The invention relates to fatty acid COX inhibitor derivatives; compositions comprising an effective amount of a fatty acid COX inhibitor derivative; and methods for treating or preventing a metabolic, autoimmune inflammatory, or neurodegenerative disorder comprising the administration of an effective amount of a fatty acid COX inhibitor derivative.

摘要翻译： 本发明涉及脂肪酸COX抑制剂衍生物; 包含有效量的脂肪酸COX抑制剂衍生物的组合物; 以及用于治疗或预防代谢，自身免疫性炎症或神经变性疾病的方法，包括施用有效量的脂肪酸COX抑制剂衍生物。

公开(公告)号：US20160015819A1

公开(公告)日：2016-01-21

申请号：US14803965

申请日：2015-07-20

申请人： Catabasis Pharmaceuticals, Inc.

发明人： Jill C. Milne ,  Michael R. Jirousek ,  Amal Ting ,  Chi B. Vu ,  Allison Wensley

IPC分类号： A61K47/48 ,  A61K31/506 ,  A61K31/40 ,  A61K31/505 ,  C07J9/00 ,  C07J43/00

CPC分类号： C07J9/00 ,  A61K31/366 ,  A61K31/40 ,  A61K31/505 ,  A61K31/506 ,  A61K47/542 ,  C07J43/003

摘要： The invention relates to fatty acid statin conjugates and fatty acid FXR agonist conjugates; compositions comprising an effective amount of a fatty acid statin conjugate or a fatty acid FXR agonist conjugate; and methods for treating or preventing a metabolic disease comprising the administration of an effective amount of a fatty acid statin conjugate or a fatty acid FXR agonist conjugate.

摘要翻译： 本发明涉及脂肪酸他汀类共轭物和脂肪酸FXR激动剂缀合物; 包含有效量的脂肪酸他汀类缀合物或脂肪酸FXR激动剂缀合物的组合物; 以及用于治疗或预防代谢疾病的方法，包括施用有效量的脂肪酸他汀类缀合物或脂肪酸FXR激动剂缀合物。