公开(公告)号：US5306412A

公开(公告)日：1994-04-26

申请号：US46379

申请日：1993-04-08

申请人： Craig M. Whitehouse ,  John B. Fenn ,  Shida Shen ,  Cawthon Smith

发明人： Craig M. Whitehouse ,  John B. Fenn ,  Shida Shen ,  Cawthon Smith

IPC分类号： B05B17/06 ,  G01N30/60 ,  G01N30/72 ,  H01J49/04 ,  G01N27/26 ,  G01N27/447 ,  H01J49/10

CPC分类号： H01J49/167 ,  B05B17/0623 ,  B05B17/063 ,  G01N30/7246 ,  G01N30/7266 ,  H01J49/0454 ,  G01N2030/6013 ,  G01N30/7273 ,  G01N30/7293

摘要： The subject invention teaches the use of mechanical vibration to enhance the electrostatic dispersion of sample solutions into the small, highly charged droplets that can produce ions of solute species for mass spectrometric analysis. Such vibration turns out to be surprisingly effective at ultrasonic frequencies for solutions with flow rates, conductivities and surface tensions too high for stable dispersion by electrostatic forces alone as in conventional electrospray ionization. Several embodiments of the invention are described for purposes of illustration. Other possible embodiments will become apparent to those skilled in the art.

摘要翻译： 本发明教导了使用机械振动来增强样品溶液到可以产生用于质谱分析的溶质物质离子的小的高电荷液滴中的静电分散。 这种振动在超声波频率下对于流速，电导率和表面张力过高，对于通过静电力的稳定分散（如在常规电喷雾离子化）中的解决方案而言，是惊人的有效的。 为了说明的目的描述了本发明的若干实施例。 其他可能的实施例对于本领域技术人员将变得显而易见。