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公开(公告)号:US08030304B2
公开(公告)日:2011-10-04
申请号:US12377733
申请日:2007-09-17
申请人: Zhaogen Chen , Chafiq Hamdouchi Hamdouchi , Erik James Hembre , Philip Arthur Hipskind , Jason Kenneth Myers , Takako Takakuwa , James Lee Toth
发明人: Zhaogen Chen , Chafiq Hamdouchi Hamdouchi , Erik James Hembre , Philip Arthur Hipskind , Jason Kenneth Myers , Takako Takakuwa , James Lee Toth
IPC分类号: A01N43/58 , A01N43/54 , A01N43/64 , A01N43/78 , A01N43/56 , A61K31/50 , A61K31/505 , A61K31/41 , A61K31/425 , A61K31/415 , C07D239/42 , C07D401/04 , C07D471/04 , C07D471/22 , C07D487/04
CPC分类号: C07D487/04
摘要: The present invention relates to compounds of Formula (I), pharmaceutical compositions thereof, and use thereof as corticotropin releasing factor 1 (CRF1) receptor antagonists in the treatment of psychiatric and neuroendocrine disorders, neurological diseases, and metabolic syndrome.
摘要翻译: 本发明涉及式(I)的化合物,其药物组合物及其作为促肾上腺皮质激素释放因子1(CRF1)受体拮抗剂在治疗精神和神经内分泌障碍,神经系统疾病和代谢综合征中的用途。
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公开(公告)号:US06358971B1
公开(公告)日:2002-03-19
申请号:US09674037
申请日:2000-12-04
申请人: Jesus Ezquerra-Carrera , Joseph Michael Gruber , Chafiq Hamdouchi Hamdouchi , Richard Elmer Holmes , Wayne Alfred Spitzer
发明人: Jesus Ezquerra-Carrera , Joseph Michael Gruber , Chafiq Hamdouchi Hamdouchi , Richard Elmer Holmes , Wayne Alfred Spitzer
IPC分类号: A61K31437
CPC分类号: C07D471/04
摘要: The present invention relates to compounds of Formula (I) below, which inhibit the growth of picornaviruses, Hepatitus viruses, enteroviruses, cardioviruses, polioviruses, coxsackieviruses of the A and B groups, echo virus and Mengo virus. wherein: A is phenyl, pyridyl, substituted phenyl, substituted pyridyl, or benzyl; R is hydrogen, COR4, or COCF3; X is N—OH, O, or CHR1; R1 is hydrogen, halo, CN, C1-C4 alkyl, —C≡CH, CO(C1-C4 alkyl), CO2(C1-C4 alkyl), or CONR2R3; R2 and R3 are independently hydrogen or C1-C4 alkyl; A′ is hydrogen, halo, C1-C6 alkyl, benzyl, naphthyl, thienyl, furyl, pyridyl, pyrollyl, COR4, S(O)nR4, or a group of the formula R4 is C1-C6 alkyl, phenyl, or substituted phenyl; n is 0, 1, or 2; R5 is independently at each occurrence hydrogen or halo; m is 1, 2, 3, or 4; and R6 is hydrogen, halo, CF3, OH, CO2H, NH2, NO2, CONHOCH3, C1-C4 alkyl, or CO2(C1-C4 alkyl), C1-C4 alkoxy; or a pharmaceutically acceptable salt thereof.
摘要翻译: 本发明涉及抑制小核糖核酸病毒,肝病毒,肠病毒,心脏病毒,脊髓灰质炎病毒,A组和B组柯萨克病毒,回波病毒和孟戈病毒的生长的下列式(I)的化合物。其中A是苯基,吡啶基 取代的苯基,取代的吡啶基或苄基; R是氢,COR4或COCF3; X是N-OH,O或CHR1; R1是氢,卤素,CN,C1-C4烷基,-C = CH, C1-C4烷基),CO2(C1-C4烷基)或CONR2R3; R2和R3独立地是氢或C1-C4烷基; A'是氢,卤素,C1-C6烷基,苄基,萘基,噻吩基,呋喃基,吡啶基 ,吡咯烷基,COR4,S(O)nR4或式R4的基团是C1-C6烷基,苯基或取代的苯基; n是0,1或2; R5各自独立地为氢或卤素; m为 1,2,3或4; 或者其药学上可接受的盐,R 6是氢,卤素,CF 3,OH,CO 2 H,NH 2,NO 2,CONHOCH 3,C 1 -C 4烷基或CO 2(C 1 -C 4烷基),C 1 -C 4烷氧基。
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公开(公告)号:US20100022560A1
公开(公告)日:2010-01-28
申请号:US12438953
申请日:2007-09-13
申请人: Zhaogen Chen , Chafiq Hamdouchi Hamdouchi , Erik James Hembre , Philip Arthur Hipskind , Shaojuan Jia , James Lee Toth
发明人: Zhaogen Chen , Chafiq Hamdouchi Hamdouchi , Erik James Hembre , Philip Arthur Hipskind , Shaojuan Jia , James Lee Toth
IPC分类号: A61K31/519 , C07D487/04 , A61P25/24 , A61P25/22
CPC分类号: C07D487/04
摘要: The present invention relates to compounds of Formula (I), pharmaceutical compositions thereof, and the use of such compounds as corticotropin releasing factor 1 (CRF1) receptor antagonists in the treatment of psychiatric and neuroendocrine disorders, neurological diseases, and metabolic syndrome.
摘要翻译: 本发明涉及式(I)的化合物,其药物组合物,以及这些化合物作为促肾上腺皮质激素释放因子1(CRF1)受体拮抗剂在治疗精神和神经内分泌障碍,神经系统疾病和代谢综合征中的用途。
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公开(公告)号:US20100222339A1
公开(公告)日:2010-09-02
申请号:US12377733
申请日:2007-09-17
申请人: Zhaogen Chen , Chafiq Hamdouchi Hamdouchi , Erik James Hembre , Philip Arthur Hipskind , Jason Kenneth Myers , Takako Takakuwa , James Lee Toth
发明人: Zhaogen Chen , Chafiq Hamdouchi Hamdouchi , Erik James Hembre , Philip Arthur Hipskind , Jason Kenneth Myers , Takako Takakuwa , James Lee Toth
IPC分类号: A61K31/5377 , C07D471/04 , A61K31/437 , C07D417/14 , A61P25/30 , A61P25/32
CPC分类号: C07D487/04
摘要: The present invention relates to compounds of Formula (I), pharmaceutical compositions thereof, and use thereof as corticotropin releasing factor 1 (CRF1) receptor antagonists in the treatment of psychiatric and neuroendocrine disorders, neurological diseases, and metabolic syndrome.
摘要翻译: 本发明涉及式(I)的化合物,其药物组合物及其作为促肾上腺皮质激素释放因子1(CRF1)受体拮抗剂在治疗精神和神经内分泌障碍,神经系统疾病和代谢综合征中的用途。
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公开(公告)号:US20090318443A1
公开(公告)日:2009-12-24
申请号:US12509886
申请日:2009-07-27
申请人: Rosanne Bonjouklian , Chafiq Hamdouchi Hamdouchi , Chuan Shih , Alfonso De Dios , Miriam Filadelfa Del Prado , Carlos Jaramillo Aguado , Pramila Kotiyan , Mary Margaret Mader , Sheila Pleite Selgas , Concepcion Sanchez-Martinez
发明人: Rosanne Bonjouklian , Chafiq Hamdouchi Hamdouchi , Chuan Shih , Alfonso De Dios , Miriam Filadelfa Del Prado , Carlos Jaramillo Aguado , Pramila Kotiyan , Mary Margaret Mader , Sheila Pleite Selgas , Concepcion Sanchez-Martinez
IPC分类号: A61K31/5377 , A61K31/437 , A61P35/00
CPC分类号: C07D471/04
摘要: The present invention provides kinase inhibitors of Formula I.
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公开(公告)号:US07320995B2
公开(公告)日:2008-01-22
申请号:US10522227
申请日:2003-07-31
申请人: Rosanne Bonjouklian , Jose Eugenio De Diego Gomez , Alfonso De Dios , Chafiq Hamdouchi Hamdouchi , Tiecho Li , Beatriz Lopez De Uralde Garmendia , Michal Vieth , Jeremy Schulenberg York , Robert Dean Dally , Miriam Filadelfa Del Prado Catalina , Carlos Jaramillo Aguado , Luisa Maria Martin-Cabrejas , Carlos Montero Salgado , Sheila Pleite Selgas , Concepcion Sanchez-Martinez , Timothy Alan Shepherd , James Howard Wikel
发明人: Rosanne Bonjouklian , Jose Eugenio De Diego Gomez , Alfonso De Dios , Chafiq Hamdouchi Hamdouchi , Tiecho Li , Beatriz Lopez De Uralde Garmendia , Michal Vieth , Jeremy Schulenberg York , Robert Dean Dally , Miriam Filadelfa Del Prado Catalina , Carlos Jaramillo Aguado , Luisa Maria Martin-Cabrejas , Carlos Montero Salgado , Sheila Pleite Selgas , Concepcion Sanchez-Martinez , Timothy Alan Shepherd , James Howard Wikel
IPC分类号: A61K31/4184 , A61K31/428 , C07D277/68 , C07D235/10
CPC分类号: C07D403/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D513/04
摘要: The present invention provides kinase inhibitors of Formula I: wherein W represents inter alia imidazol, oxazol, pyrazol, thiazol as triazol, which are substituted by phenyl or thienyl. The disclosed compounds inhibit p-38 kinase and are useful in the treatment of metastasis or rheumatoid arthritis
摘要翻译: 本发明提供式I的激酶抑制剂:其中W代表由苯基或噻吩取代的咪唑,恶唑,吡唑,噻唑三唑。 所公开的化合物抑制p-38激酶,并且可用于治疗转移或类风湿性关节炎
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