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公开(公告)号：US09164479B2
公开(公告)日：2015-10-20
申请号：US13234485
申请日：2011-09-16
CPC分类号： G03H1/0005 , G02B21/365 , G02B26/06 , G03H1/0443 , G03H1/0866 , G03H2001/005 , G03H2001/0447 , G03H2001/0454 , G03H2001/0471 , G03H2210/10 , G03H2210/12 , G03H2223/13 , G03H2223/52 , G03H2223/55 , G03H2226/13
摘要： An embodiment of the disclosed DHM system includes a light source configured to emit coherent optical waves, a first optical Fourier element configured to Fourier transform the optical waves from the object area, wherein the Fourier transform occurs at a Fourier plane and the optical waves from the object area includes directly transmitted waves and diffracted waves, a phase modulator at the Fourier plane configured to introduce a phase delay between the directly transmitted waves and the diffracted waves, a second optical Fourier element configured to receive the directly transmitted waves and the diffracted waves from the phase modulator and to inversely Fourier transform the directly transmitted waves and the diffracted waves to provide interfered optical waves, and at least one imaging device configured to record the interfered optical waves at two image planes to generate a first interferogram and a second interferogram.
摘要翻译： 所公开的DHM系统的实施例包括被配置为发射相干光波的光源，被配置为对来自物体区域的光波进行傅立叶变换的第一光学傅里叶变换元件，其中傅里叶变换发生在傅立叶平面上， 物体区域包括直接发射的波和衍射波，在傅里叶平面处的相位调制器被配置为在直接发射的波和衍射波之间引入相位延迟;第二光学傅里叶变换器元件，被配置为接收直接发射的波和衍射波 相位调制器，并且对直接发射的波和衍射波进行逆傅立叶变换以提供干涉光波;以及至少一个成像装置，被配置为在两个图像平面处记录被干扰的光波，以产生第一干涉图和第二干涉图。
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2.发明授权Systems and methods of all-optical Fourier phase contrast imaging using dye doped liquid crystals 有权使用染料掺杂液晶的全光傅里叶相位成像的系统和方法公开(公告)号：US07738047B2
公开(公告)日：2010-06-15
申请号：US11935910
申请日：2007-11-06
IPC分类号： G02F1/13
CPC分类号： G02B21/14 , G02B27/52 , G02F1/132 , G02F1/13725
摘要： Under one aspect, a phase contrast imaging system includes a coherent light source emitting a coherent beam directed toward a sample area; a lens arranged to collect at least part of the beam from the sample area; an element Fourier transforming the collected beam in a Fourier plane; a liquid crystal cell in the Fourier plane that transmits at least part of the transformed beam, wherein the cell includes liquid crystal molecules having a phase transition temperature, and wherein at temperatures exceeding the phase transition temperature, light transmitted through the liquid crystal molecules obtains a different phase than light transmitted through the liquid crystal molecules obtains at temperatures below the phase transition temperature; and an element inversely Fourier transforming the transmitted beam to provide an image. Part of the transformed beam has an intensity sufficient to heat a portion of the liquid crystal molecules above the phase transition temperature.
摘要翻译： 在一个方面，相位对比成像系统包括发射朝向样本区域的相干光束的相干光源; 透镜，布置成从样品区域收集至少一部分光束; 在傅立叶平面中傅里叶变换收集的光束的元素; 透射至少部分变换束的傅立叶平面中的液晶单元，其中，所述单元包括具有相变温度的液晶分子，并且其中在超过相变温度的温度下，透过液晶分子的光获得 不同于透过液晶分子的光在低于相变温度的温度下获得; 以及将透射光束逆傅立叶变换以提供图像的元素。 变换束的一部分具有足以将一部分液晶分子加热到相转变温度以上的强度。
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3.发明申请Systems and Methods of All-Optical Fourier Phase Contrast Imaging Using Dye Doped Liquid Crystals 有权使用染料掺杂液晶的全光傅立叶相位对比成像系统和方法公开(公告)号：US20100245694A1
公开(公告)日：2010-09-30
申请号：US12795974
申请日：2010-06-08
CPC分类号： G02B21/14 , G02B27/52 , G02F1/132 , G02F1/13725
摘要： An assembly for converting a microscope into a phase contrast microscope includes a first optical Fourier element that Fourier transforms light from a coherent light source, a cell in the Fourier plane arranged to receive light from the first optical Fourier element, a second optical Fourier element arranged to receive light from the cell and inversely Fourier transform the received light to provide an image, an image sensor that detects the image and generates an electronic representation of the image, and an adaptor capable of coupling the first and second Fourier elements, the cell, and the image sensor to the microscope such that the first Fourier element Fourier transforms light collected by the microscope objective. The cell includes liquid crystal molecules having a phase transition temperature, wherein at temperatures exceeding the phase transition temperature, light transmitting through the liquid crystal molecules obtains a different phase than light transmitting through the liquid crystal molecules at temperatures below the phase transition temperature.
摘要翻译： 用于将显微镜转换成相差显微镜的组件包括傅里叶变换来自相干光源的光的第一光学傅里叶变换元件，布置成从第一光学傅里叶变换元件接收光的傅立叶平面中的单元，布置成 从单元接收光并对接收的光进行逆傅里叶变换以提供图像;图像传感器，其检测图像并生成图像的电子表示;以及适配器，其能够耦合第一和第二傅立叶元件，单元， 和图像传感器到显微镜，使得第一傅里叶元素傅里叶变换由显微镜物镜收集的光。 电池包括具有相变温度的液晶分子，其中在超过相变温度的温度下，透过液晶分子的光获得与低于相变温度的温度下透过液晶分子的光的不同相位。
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公开(公告)号：US20130070251A1
公开(公告)日：2013-03-21
申请号：US13234485
申请日：2011-09-16
IPC分类号： G01B9/021
CPC分类号： G03H1/0005 , G02B21/365 , G02B26/06 , G03H1/0443 , G03H1/0866 , G03H2001/005 , G03H2001/0447 , G03H2001/0454 , G03H2001/0471 , G03H2210/10 , G03H2210/12 , G03H2223/13 , G03H2223/52 , G03H2223/55 , G03H2226/13
摘要： An embodiment of the disclosed DHM system includes a light source configured to emit coherent optical waves, a first optical Fourier element configured to Fourier transform the optical waves from the object area, wherein the Fourier transform occurs at a Fourier plane and the optical waves from the object area includes directly transmitted waves and diffracted waves, a phase modulator at the Fourier plane configured to introduce a phase delay between the directly transmitted waves and the diffracted waves, a second optical Fourier element configured to receive the directly transmitted waves and the diffracted waves from the phase modulator and to inversely Fourier transform the directly transmitted waves and the diffracted waves to provide interfered optical waves, and at least one imaging device configured to record the interfered optical waves at two image planes to generate a first interferogram and a second interferogram.
摘要翻译： 所公开的DHM系统的实施例包括被配置为发射相干光波的光源，被配置为对来自物体区域的光波进行傅立叶变换的第一光学傅里叶变换元件，其中傅里叶变换发生在傅立叶平面上， 物体区域包括直接发射的波和衍射波，在傅里叶平面处的相位调制器被配置为在直接发射的波和衍射波之间引入相位延迟;第二光学傅里叶变换器元件，被配置为接收直接发射的波和衍射波 相位调制器，并且对直接发射的波和衍射波进行逆傅立叶变换以提供干涉光波;以及至少一个成像装置，被配置为在两个图像平面处记录被干扰的光波，以产生第一干涉图和第二干涉图。
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5.发明授权Systems and methods of all-optical fourier phase contrast imaging using dye doped liquid crystals 有权使用染料掺杂液晶的全光学傅立叶相位成像的系统和方法公开(公告)号：US07880820B2
公开(公告)日：2011-02-01
申请号：US12795974
申请日：2010-06-08
IPC分类号： G02F1/1335
CPC分类号： G02B21/14 , G02B27/52 , G02F1/132 , G02F1/13725
摘要： An assembly for converting a microscope into a phase contrast microscope includes a first optical Fourier element that Fourier transforms light from a coherent light source, a cell in the Fourier plane arranged to receive light from the first optical Fourier element, a second optical Fourier element arranged to receive light from the cell and inversely Fourier transform the received light to provide an image, an image sensor that detects the image and generates an electronic representation of the image, and an adaptor capable of coupling the first and second Fourier elements, the cell, and the image sensor to the microscope such that the first Fourier element Fourier transforms light collected by the microscope objective. The cell includes liquid crystal molecules having a phase transition temperature, wherein at temperatures exceeding the phase transition temperature, light transmitting through the liquid crystal molecules obtains a different phase than light transmitting through the liquid crystal molecules at temperatures below the phase transition temperature.
摘要翻译： 用于将显微镜转换成相差显微镜的组件包括傅里叶变换来自相干光源的光的第一光学傅里叶变换元件，布置成从第一光学傅里叶变换元件接收光的傅立叶平面中的单元，布置成 从单元接收光并对接收的光进行逆傅里叶变换以提供图像;图像传感器，其检测图像并生成图像的电子表示;以及适配器，其能够耦合第一和第二傅立叶元件，单元， 和图像传感器到显微镜，使得第一傅里叶元素傅里叶变换由显微镜物镜收集的光。 电池包括具有相变温度的液晶分子，其中在超过相变温度的温度下，透过液晶分子的光获得与低于相变温度的温度下透过液晶分子的光的不同相位。
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公开(公告)号：US07653232B2
公开(公告)日：2010-01-26
申请号：US11342254
申请日：2006-01-27
CPC分类号： G06T7/0012 , A61B6/583 , G06T2207/30068
摘要： The present invention relates to systems and methods for medical imaging. Digital images are processed to provide phase images of a region of interest to aid in the diagnosis and treatment of various conditions. A preferred embodiment of the invention provides improved mammography screening for cancerous or precancerous conditions.
摘要翻译： 本发明涉及用于医学成像的系统和方法。 处理数字图像以提供感兴趣区域的相位图像，以帮助诊断和处理各种条件。 本发明的优选实施方案提供了用于癌性或癌前病症的改进的乳房摄影术筛选。
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7.发明申请SYSTEMS AND METHODS OF ALL-OPTICAL FOURIER PHASE CONTRAST IMAGING USING DYE DOPED LIQUID CRYSTALS 有权使用DYD DOPED液晶的全光学相位对比成像系统和方法公开(公告)号：US20080174860A1
公开(公告)日：2008-07-24
申请号：US11935910
申请日：2007-11-06
IPC分类号： G02B21/14
CPC分类号： G02B21/14 , G02B27/52 , G02F1/132 , G02F1/13725
摘要： Under one aspect, a phase contrast imaging system includes a coherent light source emitting a coherent beam directed toward a sample area; a lens arranged to collect at least part of the beam from the sample area; an element Fourier transforming the collected beam in a Fourier plane; a liquid crystal cell in the Fourier plane that transmits at least part of the transformed beam, wherein the cell includes liquid crystal molecules having a phase transition temperature, and wherein at temperatures exceeding the phase transition temperature, light transmitted through the liquid crystal molecules obtains a different phase than light transmitted through the liquid crystal molecules obtains at temperatures below the phase transition temperature; and an element inversely Fourier transforming the transmitted beam to provide an image. Part of the transformed beam has an intensity sufficient to heat a portion of the liquid crystal molecules above the phase transition temperature.
摘要翻译： 在一个方面，相位对比成像系统包括发射朝向样本区域的相干光束的相干光源; 透镜，布置成从样品区域收集至少一部分光束; 在傅立叶平面中傅里叶变换收集的光束的元素; 透射至少部分变换光束的傅立叶平面中的液晶单元，其中，所述单元包括具有相变温度的液晶分子，并且其中在超过相变温度的温度下，透过液晶分子的光获得 不同于透过液晶分子的光在低于相变温度的温度下获得; 以及将透射光束逆傅立叶变换以提供图像的元素。 变换束的一部分具有足以将一部分液晶分子加热到相转变温度以上的强度。
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