公开(公告)号：US20170369864A1

公开(公告)日：2017-12-28

申请号：US15633254

申请日：2017-06-26

Applicant: Niraj Tolia ,  Gautam Dantas ,  Timothy Wencewicz ,  Jooyoung Park ,  Andrew Gasparrini ,  Kevin Forsberg ,  Joseph Vogel ,  Margaret Ruth Reck ,  Chanez Tiffany Symister ,  Jana L. Markley

Inventor： Niraj Tolia ,  Gautam Dantas ,  Timothy Wencewicz ,  Jooyoung Park ,  Andrew Gasparrini ,  Kevin Forsberg ,  Joseph Vogel ,  Margaret Ruth Reck ,  Chanez Tiffany Symister ,  Jana L. Markley

IPC: C12N9/99 ,  C12Q1/04 ,  A61K39/40 ,  A61K38/00 ,  A61K31/65 ,  A61K47/00 ,  C12N9/00

CPC classification number: C12N9/99 ,  A61K31/65 ,  A61K38/005 ,  A61K39/40 ,  A61K47/00 ,  A61K47/6809 ,  C12N9/00 ,  C12Q1/04 ,  Y02A50/478

Abstract: The present disclosure provides compositions and methods for treating bacterial infections in a subject. The methods comprise administering a compound that binds a FAD-dependent flavoenzyme and a tetracycline, analog, derivative, or pharmaceutically acceptable salt thereof.

公开(公告)号：US10273468B2

公开(公告)日：2019-04-30

申请号：US15633254

申请日：2017-06-26

Applicant: Niraj Tolia ,  Gautam Dantas ,  Timothy Wencewicz ,  Jooyoung Park ,  Andrew Gasparrini ,  Kevin Forsberg ,  Joseph Vogel ,  Margaret Ruth Reck ,  Chanez Tiffany Symister ,  Jana L. Markley

Inventor： Niraj Tolia ,  Gautam Dantas ,  Timothy Wencewicz ,  Jooyoung Park ,  Andrew Gasparrini ,  Kevin Forsberg ,  Joseph Vogel ,  Margaret Ruth Reck ,  Chanez Tiffany Symister ,  Jana L. Markley

IPC: C12N9/99 ,  C12Q1/04 ,  A61K39/40 ,  A61K38/00 ,  A61K31/65 ,  A61K47/00 ,  C12N9/00 ,  A61K47/68

Abstract: The present disclosure provides compositions and methods for treating bacterial infections in a subject. The methods comprise administering a compound that binds a FAD-dependent flavoenzyme and a tetracycline, analog, derivative, or pharmaceutically acceptable salt thereof.