公开(公告)号：US20070034812A1

公开(公告)日：2007-02-15

申请号：US11445850

申请日：2006-06-01

申请人： Chang-Ming Ma ,  Eugene Fourkal

发明人： Chang-Ming Ma ,  Eugene Fourkal

IPC分类号： H01J37/08

CPC分类号： A61N5/1031 ,  A61N5/1043 ,  A61N2005/1087 ,  A61N2005/1088 ,  G21K5/04 ,  G21K2201/00

摘要： Methods of optimizing a laser-accelerated proton radiation dose to a targeted region are disclosed. Disclosed methods include providing a plurality of modulated polyenergetic proton beamlets and irradiating the targeted region with the plurality of modulated beamlets.

公开(公告)号：US20060145088A1

公开(公告)日：2006-07-06

申请号：US10559058

申请日：2004-06-02

申请人： Chang-Ming Ma

发明人： Chang-Ming Ma

IPC分类号： H01J1/50

CPC分类号： G21K1/08 ,  A61N2005/1087 ,  A61N2005/1088 ,  G21K5/04 ,  H05H7/04 ,  H05H15/00

摘要： Devices and methods are provided for generating laser-accelerated high energy polyenergetic positive ion beams that are spatially separated and modulated based on energy level. The spatially separated and modulated high energy polyenergetic positive ion beams are used for radiation therapy. In addition, methods are provided for treating patients in radiation treatment centers using therapeutically suitable high energy polyenergetic positive ion beams that are provided by spatially separating and modulating positive ion beams. The production of radioisotopes using spatially separated and modulated laser-accelerated high energy polyenergetic positive ion beams is also provided.

摘要翻译： 提供了用于产生基于能级空间分离和调制的激光加速的高能多能正离子束的装置和方法。 空间分离和调制的高能多能正离子束用于放射治疗。 另外，提供了使用由空间上分离和调节正离子束提供的治疗上合适的高能多能正离子束来治疗放射治疗中心的患者的方法。 还提供了使用空间分离和调制的激光加速高能多能正离子束的放射性同位素的生产。

公开(公告)号：US20090050819A1

公开(公告)日：2009-02-26

申请号：US11720873

申请日：2005-12-21

申请人： Chang Ming Ma ,  Eugene S. Fourkal ,  Jinsheng Li ,  Wei Luo

发明人： Chang Ming Ma ,  Eugene S. Fourkal ,  Jinsheng Li ,  Wei Luo

IPC分类号： H01J3/14 ,  A61N5/00 ,  H01F6/00

CPC分类号： A61N5/10 ,  A61N2005/1087 ,  A61N2005/1088 ,  G21K1/093 ,  G21K5/04 ,  H05H15/00

摘要： Compact particle selection and collimation devices are disclosed for delivering beams of protons with desired energy spectra. These devices are useful with laser-accelerated proton therapy systems, in which the initial protons have broad energy and angular distributions. Superconducting magnet systems produce a desired magnetic field configuration to spread the protons with different energies and emitting angles for particle selection. The simulation of proton transport in the presence of the magnetic field shows that the selected protons are successfully refocused on the beam axis after passing through the magnetic field with the optimal magnet system. Dose distributions are also provided using Monte Carlo simulations of the laser-accelerated proton beams for radiation therapy applications.

摘要翻译： 公开了紧凑的粒子选择和准直装置，用于以期望的能谱输送质子束。 这些装置对于激光加速质子治疗系统是有用的，其中初始质子具有宽的能量和角分布。 超导磁体系统产生期望的磁场结构，以用不同的能量和发射角来扩散质子用于粒子选择。 在存在磁场的情况下，质子传输的模拟表明，所选择的质子在通过具有最佳磁体系统的磁场之后成功地重新聚焦在光束轴上。 使用激光加速质子束的蒙特卡罗模拟也可以提供剂量分布，用于放射治疗应用。

公开(公告)号：US08269189B2

公开(公告)日：2012-09-18

申请号：US12742769

申请日：2008-11-13

申请人： Chang-ming Ma ,  Iavor Veltchev ,  Eugene S. Fourkal

发明人： Chang-ming Ma ,  Iavor Veltchev ,  Eugene S. Fourkal

IPC分类号： H01J49/06

CPC分类号： H05H15/00

摘要： The energy of positive ions accelerated in laser-matter interaction experiments can be significantly increased by providing a plurality of laser pulses, e.g., through the process of splitting the incoming laser pulse, to form multiple laser-matter interaction stages. From a thermodynamic point of view, the splitting procedure can be viewed as an effective way of increasing the efficiency of energy transfer from the laser light to positive ions, which energy peaks for processes having the least amount of entropy gain. A 100% increase in the energy efficiency is achieved for a six-stage laser positive ion accelerator compared to a single-stage laser positive ion accelerator.

摘要翻译： 激光物质相互作用实验中加速的正离子的能量可以通过提供多个激光脉冲，例如通过分离入射的激光脉冲的过程形成多个激光物质相互作用阶段来显着增加。 从热力学的角度来看，分裂过程可以被看作是提高从激光到正离子的能量转移效率的有效方式，对于具有最小熵增益的过程的能量峰值。 与单级激光正离子加速器相比，六级激光正离子加速器的能量效率提高了100％。

公开(公告)号：US20110198516A1

公开(公告)日：2011-08-18

申请号：US12681019

申请日：2008-10-01

申请人： Jiajin Fan ,  Chang Ming Ma

发明人： Jiajin Fan ,  Chang Ming Ma

IPC分类号： G21F1/12

CPC分类号： G21F1/125 ,  A61N2005/1087 ,  A61N2005/1088 ,  A61N2005/1094 ,  G21F7/00

摘要： Disclosed are radiation shields substantially enclosing a source of polyenergetic positive ions. The shielding layers are spatially arranged to absorb substantially all unwanted radiation arising directly or indirectly from the polyenergetic positive Also disclosed are methods of shielding unwanted radiation leaking from a system providing a therapeutic dose of polyenergetic positive radiation, as well as shielded polyenergetic positive ion selection systems.

摘要翻译： 公开了基本上包围多能正离子源的辐射屏蔽。 屏蔽层在空间上被布置成吸收基本上从多能量阳极直接或间接产生的所有不需要的辐射。还公开了屏蔽从提供治疗剂量的多能正阳性辐射的系统泄漏的不需要的辐射的方法以及屏蔽多能正离子选择系统 。

公开(公告)号：US07755068B2

公开(公告)日：2010-07-13

申请号：US11720873

申请日：2005-12-21

申请人： Chang Ming Ma ,  Eugene S Fourkal ,  Jinsheng Li ,  Wei Luo

发明人： Chang Ming Ma ,  Eugene S Fourkal ,  Jinsheng Li ,  Wei Luo

IPC分类号： G21K5/04

CPC分类号： A61N5/10 ,  A61N2005/1087 ,  A61N2005/1088 ,  G21K1/093 ,  G21K5/04 ,  H05H15/00

摘要： Compact particle selection and collimation devices are disclosed for delivering beams of ions with desired energy spectra. These devices are useful with laser-accelerated ion therapy systems, in which the initial ions have broad energy and angular distributions. Superconducting electromagnet systems produce a desired magnetic field configuration to spread the ions with different energies and emitting angles for particle selection. The simulation of ion transport in the presence of the magnetic field shows that the selected ions are successfully refocused on the beam axis after passing through the magnetic field. Dose distributions are also provided using Monte Carlo simulations of the laser-accelerated ion beams for radiation therapy applications.

摘要翻译： 公开了紧凑的粒子选择和准直装置，用于以期望的能谱输送离子束。 这些装置对于激光加速离子治疗系统是有用的，其中初始离子具有宽的能量和角分布。 超导电磁体系统产生期望的磁场结构，以便以不同的能量和发射角来扩散离子以进行粒子选择。 在存在磁场的情况下，离子迁移的模拟表明，所选择的离子在通过磁场后成功地重新聚焦在光束轴上。 使用激光加速离子束的蒙特卡罗模拟也可以提供剂量分布，用于放射治疗应用。

公开(公告)号：US20090230318A1

公开(公告)日：2009-09-17

申请号：US11720886

申请日：2005-12-22

申请人： Eugene S Fourkal ,  Iavor Veltchev ,  Chang Ming Ma

发明人： Eugene S Fourkal ,  Iavor Veltchev ,  Chang Ming Ma

IPC分类号： H01J27/00 ,  G21K1/00 ,  A61N5/00

CPC分类号： H01J27/24 ,  G21B1/19 ,  H01L21/268 ,  Y02E30/16

摘要： Methods for designing a laser-accelerated ion beam are disclosed. The methods include modeling a system including a heavy ion layer, an electric field, and high energy light positive ions having a maximum light positive ion energy, correlating physical parameters of the heavy ion layer, the electric field, and the maximum light positive ion energy using the model, and varying the parameters of the heavy ion layer to optimize the energy distribution of the high energy light positive ions. One method includes analyzing the acceleration of light positive ions, for example protons, through interaction of a high-power laser pulse with a double-layer target using two-dimensional particle-in-cell (PIC) simulations and a one-dimensional analytical model. The maximum energy acquired by the accelerated light positive ions, e.g., protons, in this model depends on the physical characteristics of the heavy-ion layer—the electron-ion mass ratio and effective charge state of the ions. The hydrodynamic equations for both electron and heavy ion species solved and the test-particle approximation for the protons is applied. It was found that the heavy ion motion modifies the longitudinal electric field distribution, thus changing the acceleration conditions for the light positive ions.

摘要翻译： 公开了设计激光加速离子束的方法。 所述方法包括对包括重离子层，电场和具有最大的光正离子能量的高能量的光正离子进行建模，将重离子层的物理参数，电场和最大的光正离子能量相关联 使用该模型，改变重离子层的参数，以优化高能光阳离子的能量分布。 一种方法包括通过使用二维粒子单元（PIC）模拟的高功率激光脉冲与双层靶的相互作用来分析光正离子（例如质子）的加速度，以及一维分析模型 。 在该模型中由加速的光正离子（例如质子）获得的最大能量取决于重离子层的物理特性 - 离子的电子 - 离子质量比和有效电荷状态。 解决了电子和重离子物质的流体动力学方程，并应用质子的测试粒子近似。 发现重离子运动改变纵向电场分布，从而改变光正离子的加速条件。

公开(公告)号：US07268358B2

公开(公告)日：2007-09-11

申请号：US11445850

申请日：2006-06-01

申请人： Chang-Ming Ma ,  Eugene S. Fourkal

发明人： Chang-Ming Ma ,  Eugene S. Fourkal

IPC分类号： H01J37/08 ,  G21K5/10

CPC分类号： A61N5/1031 ,  A61N5/1043 ,  A61N2005/1087 ,  A61N2005/1088 ,  G21K5/04 ,  G21K2201/00

摘要： Methods of optimizing a laser-accelerated proton radiation dose to a targeted region are disclosed. Disclosed methods include providing a plurality of modulated polyenergetic proton beamlets and irradiating the targeted region with the plurality of modulated beamlets.

摘要翻译： 公开了将目标区域的激光加速质子辐射剂量优化的方法。 公开的方法包括提供多个调制的多能子质子子束并用多个调制子束照射目标区域。

公开(公告)号：US20100320394A1

公开(公告)日：2010-12-23

申请号：US12742769

申请日：2008-11-13

申请人： Chang-ming Ma ,  Iavor Veltchev ,  Eugene S. Fourkal

发明人： Chang-ming Ma ,  Iavor Veltchev ,  Eugene S. Fourkal

IPC分类号： H05H15/00 ,  H01J27/00

CPC分类号： H05H15/00

摘要： The energy of positive ions accelerated in laser-matter interaction experiments can be significantly increased by providing a plurality of laser pulses, e.g., through the process of splitting the incoming laser pulse, to form multiple laser-matter interaction stages. From a thermodynamic point of view, the splitting procedure can be viewed as an effective way of increasing the efficiency of energy transfer from the laser light to positive ions, which energy peaks for processes having the least amount of entropy gain. A 100% increase in the energy efficiency is achieved for a six-stage laser positive ion accelerator compared to a single-stage laser positive ion accelerator.

摘要翻译： 激光物质相互作用实验中加速的正离子的能量可以通过提供多个激光脉冲，例如通过分离入射的激光脉冲的过程形成多个激光物质相互作用阶段来显着增加。 从热力学的角度来看，分裂过程可以被看作是提高从激光到正离子的能量转移效率的有效方式，对于具有最小熵增益的过程的能量峰值。 与单级激光正离子加速器相比，六级激光正离子加速器的能量效率提高了100％。