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公开(公告)号：US08617200B2
公开(公告)日：2013-12-31
申请号：US13211409
申请日：2011-08-17
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61F2/82 , A61F2002/016 , A61F2230/0093 , A61F2250/0023
摘要： A filter device assembly and a method of using such a device to capture and remove embolic material from a body lumen or blood vessel are provided. The filter device assembly generally includes a structure having a collapsed state and an expanded state with first, second, and optionally N additional filter members circumferentially attached thereto. Each filter member forms an annulus chamber with the first filter member having porosity P1; the second filter member circumferentially having porosity P2; and the N additional filter members each having porosity [P3 . . . P(2+N)]. The magnitude of the porosity for the first, second, and N additional filter members follows the relationship P1>[P3> . . . >P(2+N)]>P2. The first, second, and N additional filter portions are configured in the expanded state to allow blood to flow there through and to capture emboli in the annulus chambers.
摘要翻译： 提供了一种过滤器装置组件和使用这种装置从体腔或血管捕获和去除栓塞材料的方法。 过滤装置组件通常包括具有收缩状态和膨胀状态的结构，其中第一，第二和任选地N个额外的过滤构件周向地附接到其上。 每个过滤器构件形成具有孔隙率P1的第一过滤构件的环空室; 周向具有孔P2的第二过滤构件; 并且N个附加的过滤器构件各自具有孔隙率[P3。 。 。 P（2 + N）]。 第一，第二和第N附加过滤器构件的孔隙度的大小遵循关系P1> [P3>。 。 。 > P（2 + N）]> P2。 第一，第二和第N附加过滤器部分被配置为膨胀状态，以允许血液在那里流过并捕获环空室中的栓塞。
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2.发明授权公开(公告)号：US08211165B1
公开(公告)日：2012-07-03
申请号：US12350561
申请日：2009-01-08
IPC分类号： A61F2/06
CPC分类号： A61F2/2475 , A61F2250/0031 , A61F2250/0059
摘要： A device for implantation in a body vessel is provided. The device includes a frame that accommodates dynamic variation in the size of the vessel. At least one leaflet is attached to the frame. The leaflet is deformable between a first position allowing fluid flow in a first, antegrade direction and a second position restricting fluid flow in a second, retrograde direction. Methods for delivering the device to a body vessel and methods and kits for treating a subject using such a device are also provided.
摘要翻译： 提供了用于植入体内容器的装置。 该装置包括容纳容器尺寸的动态变化的框架。 至少一个传单附在框架上。 所述小叶可以在第一位置和第二位置之间变形，所述第一位置允许流体在第一顺行方向上流动，并且限制第二逆向方向上的流体流动。 还提供了将装置输送到身体容器的方法以及用于使用这种装置治疗受试者的方法和试剂盒。
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公开(公告)号：US20080200899A1
公开(公告)日：2008-08-21
申请号：US12034186
申请日：2008-02-20
申请人： Charles L. McIntosh
发明人： Charles L. McIntosh
CPC分类号： A61K35/34 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/1858 , A61K38/1866 , A61K2300/00
摘要： The invention relates to a method of engrafting donor cells into injured myocardium. The method includes delivering donor cells to a delivery site adjacent to and downstream of a chronic total occlusion and treating the chronic total occlusion. The delivery device may be a catheter with a wireguide that may be provided by a retrograde approach via an un-occluded artery or antegrade approach through the chronic total occlusion. The invention also relates to a method of treating injured myocardium and cell compositions for treatment of injured myocardium.
摘要翻译： 本发明涉及将供体细胞移植到损伤心肌中的方法。 该方法包括将供体细胞递送至慢性全闭塞附近和下游的递送部位并治疗慢性完全闭塞。 递送装置可以是具有导线的导管，其可以通过经由未闭塞动脉的逆行进近或通过慢性完全闭塞的顺行方法提供。 本发明还涉及一种治疗受伤心肌的方法和用于治疗受伤心肌的细胞组合物。
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公开(公告)号：US08475516B2
公开(公告)日：2013-07-02
申请号：US13363871
申请日：2012-02-01
IPC分类号： A61F2/06
CPC分类号： A61F2/2418 , A61F2/01 , A61F2/2412 , A61F2/2475 , A61F2/848 , A61F2/86 , A61F2/88 , A61F2002/016 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2220/0066 , A61F2220/0075 , A61F2230/0013 , A61F2230/0021 , A61F2230/0026
摘要： A low profile support frame for use as an or in an expandable intraluminal medical device includes first and second wire members that define arcuate paths having opposing curves. Connectors join the wire members, and barbs can be disposed on the connectors. The support frame has radially compressed and radially expanded configurations. When the support frame is in the radially expanded configuration, substantially no portion of the support frame is disposed on a first transverse axis of the frame opposite one end of the frame and substantially no portion of the frame is disposed on a second transverse axis of the frame opposite the other end of the frame. The support frame can be used as an intraluminal medical device by itself or as a component in a medical device that includes other components, such as a stent, prosthetic valve, occluder, or filter.
摘要翻译： 用作可扩展管腔内医疗装置中的或在可扩展的管腔内医疗装置中的低调支撑框架包括限定具有相对曲线的弓形路径的第一和第二线构件。 连接器连接线构件，倒钩可以设置在连接器上。 支撑框架具有径向压缩和径向扩张的构造。 当支撑框架处于径向展开构型时，支撑框架的基本上没有部分设置在与框架的一端相对的框架的第一横向轴线上，并且基本上没有框架的任何部分设置在框架的第二横向轴线上 框架与框架的另一端相对。 支撑框架可以作为管腔内医疗装置本身或作为包括其它部件（例如支架，假体瓣膜，封堵器或过滤器）的医疗装置中的部件使用。
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公开(公告)号：US20130023802A1
公开(公告)日：2013-01-24
申请号：US13555685
申请日：2012-07-23
申请人： Charles L. McIntosh , Ram H. Paul, JR. , Darin G. Schaeffer , M. Kem Hawkins , Frank J. Fischer, JR. , Grant T. Hoffman
发明人： Charles L. McIntosh , Ram H. Paul, JR. , Darin G. Schaeffer , M. Kem Hawkins , Frank J. Fischer, JR. , Grant T. Hoffman
CPC分类号： A61B17/22004 , A61B2017/22001 , A61B2017/22008 , A61B2017/22051 , A61B2017/22088 , A61B2017/22089 , A61M25/10 , A61M37/0092 , A61M2025/1013 , A61M2025/105
摘要： A device for thrombolytic therapy is provided. The device includes an elongate catheter with a distal end portion and a proximal end portion and a first lumen extending through both distal and proximal end portions. The distal end portion of the catheter includes an echogenic tubular potion that defines or surrounds a portion of the first lumen. An expandable balloon coaxially surrounds the tubular portion. The tubular portion additionally includes a plurality of indentations defined upon an outer surface thereof.
摘要翻译： 提供溶栓治疗装置。 该装置包括具有远端部分和近端部分以及延伸穿过远端部分和近端部分的第一腔的细长导管。 导管的远端部分包括限定或围绕第一内腔的一部分的回声管状药水。 可扩张气囊同轴地围绕管状部分。 管状部分还包括限定在其外表面上的多个凹口。
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公开(公告)号：US08246601B2
公开(公告)日：2012-08-21
申请号：US12034186
申请日：2008-02-20
申请人： Charles L. McIntosh
发明人： Charles L. McIntosh
IPC分类号： A61M31/00
CPC分类号： A61K35/34 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/1858 , A61K38/1866 , A61K2300/00
摘要： The invention relates to a method of engrafting donor cells into injured myocardium. The method includes delivering donor cells to a delivery site adjacent to and downstream of a chronic total occlusion and treating the chronic total occlusion. The delivery device may be a catheter with a wireguide that may be provided by a retrograde approach via an un-occluded artery or antegrade approach through the chronic total occlusion. The invention also relates to a method of treating injured myocardium and cell compositions for treatment of injured myocardium.
摘要翻译： 本发明涉及将供体细胞移植到损伤心肌中的方法。 该方法包括将供体细胞递送至慢性全闭塞附近和下游的递送部位并治疗慢性完全闭塞。 递送装置可以是具有导线的导管，其可以通过经由未闭塞动脉的逆行进近或通过慢性完全闭塞的顺行方法提供。 本发明还涉及一种治疗受伤心肌的方法和用于治疗受伤心肌的细胞组合物。
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公开(公告)号：US5693072A
公开(公告)日：1997-12-02
申请号：US448045
申请日：1995-05-23
申请人： Charles L. McIntosh
发明人： Charles L. McIntosh
CPC分类号： A61B17/06066 , A61B17/0493 , A61B2017/06085 , A61B2090/0801
摘要： A surgical needle for use in suturing non-cutaneous soft tissues of the body. The surgical needle includes a needle shaft and a needle tip formed of a rigid material suitable for use inside the body. The needle tip has a body portion integrally formed with and extending from the needle shaft and is tapered along its length. The needle tip is further provided with a blunt head which together with the body portion defines a continuously smooth outer surface lacking any sharp cutting edges. The blunt head is adapted to penetrate muscle and fascia, muscle alone, adipose, pericostal tissue and other non-cutaneous soft tissues or the body while at the same time preventing skin penetration of the gloved hand of an operator.
摘要翻译： 用于缝合身体的非皮肤软组织的外科手术针。 手术针包括针轴和由适于在体内使用的刚性材料形成的针尖。 针尖具有与针轴一体形成并从针轴延伸的主体部分，并且沿其长度逐渐变细。 针尖还设置有钝头，其与主体部分一起限定了没有任何锋利的切割边缘的连续光滑的外表面。 钝头适合于穿透肌肉和筋膜，单独肌肉，脂肪，周围组织和其他非皮肤软组织或身体，同时防止手套的手的皮肤穿透。
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公开(公告)号：US08109990B2
公开(公告)日：2012-02-07
申请号：US12711915
申请日：2010-02-24
IPC分类号： A61F2/82
CPC分类号： A61F2/2418 , A61F2/01 , A61F2/2412 , A61F2/2475 , A61F2/848 , A61F2/86 , A61F2/88 , A61F2002/016 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2220/0066 , A61F2220/0075 , A61F2230/0013 , A61F2230/0021 , A61F2230/0026
摘要： A low profile support frame for use as an or in an expandable intraluminal medical device includes first and second wire members that define arcuate paths having opposing curves. Connectors join the wire members, and barbs can be disposed on the connectors. The support frame has radially compressed and radially expanded configurations. When the support frame is in the radially expanded configuration, substantially no portion of the support frame is disposed on a first transverse axis of the frame opposite one end of the frame and substantially no portion of the frame is disposed on a second transverse axis of the frame opposite the other end of the frame. The support frame can be used as an intraluminal medical device by itself or as a component in a medical device that includes other components, such as a stent, prosthetic valve, occluder, or filter.
摘要翻译： 用作可扩展管腔内医疗装置中的或在可扩展的管腔内医疗装置中的低调支撑框架包括限定具有相对曲线的弓形路径的第一和第二线构件。 连接器连接线构件，倒钩可以设置在连接器上。 支撑框架具有径向压缩和径向扩张的构造。 当支撑框架处于径向展开构型时，支撑框架的基本上没有部分设置在与框架的一端相对的框架的第一横向轴线上，并且基本上没有框架的任何部分设置在框架的第二横向轴线上 框架与框架的另一端相对。 支撑框架可以作为管腔内医疗装置本身或作为包括其它部件（例如支架，假体瓣膜，封堵器或过滤器）的医疗装置中的部件使用。
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公开(公告)号：US09101449B2
公开(公告)日：2015-08-11
申请号：US13610963
申请日：2012-09-12
IPC分类号： A61F2/01
CPC分类号： A61F2/01 , A61F2002/011
摘要： There are disclosed embodiments of a system for retrieving a filter device from within a patient. A tube or sheath and one or more cables or other elongated members, which include a protrusion such as a bead at or adjacent a distal end, are movable with respect to each other. When the tube or sheath is adjacent a filter device, the cable or elongated member is extended so that the protrusion is between or through wires of the filter, and the protrusion is engaged to or between two or more of the wires. The filter is placed within the tube or sheath, as by retracting the cable or elongated member to pull the filter, by moving the tube or sheath over the cable or elongated member while it engages the filter under tension, or both.
摘要翻译： 已经公开了用于从患者内检索过滤器装置的系统的实施例。 管或鞘和一个或多个电缆或其它细长构件，其包括诸如在远端处或邻近远端的凸起的突起，可相对于彼此移动。 当管或护套与过滤器装置相邻时，电缆或细长构件被延伸，使得突起位于过滤器的线之间或通过过滤器的导线，并且突起接合到两根或更多根线之间或之中。 过滤器放置在管或护套内，通过缩回电缆或细长构件来拉动过滤器，通过在管线或细长构件在张力下接合过滤器或两者时将管或护套移动通过电缆或细长构件。
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公开(公告)号：US08821565B2
公开(公告)日：2014-09-02
申请号：US13477452
申请日：2012-05-22
CPC分类号： A61F2/07 , A61F2/064 , A61F2/89 , A61F2/90 , A61F2/97 , A61F2002/075 , A61F2002/8483 , Y10S623/903
摘要： An assembly for open surgical repair of a damaged wall portion of a body vessel includes a stent/graft device comprising an elongated stent body and a graft material covering the stent body. The device is expandable from a compressed condition having a diameter less than a diameter of the vessel to an expanded condition at least as great as the diameter of the vessel. A sheath enclosing the device when in the compressed condition includes a sheath body and a pull string for selectively splitting the sheath body to allow expansion of the device. The device and enclosing sheath are sized for insertion through the damaged wall portion into the vessel, wherein the pull string is extendable through the damaged wall portion for splitting the sheath body.
摘要翻译： 用于身体容器的损伤壁部分的开放手术修复的组件包括支架/移植装置，其包括细长支架主体和覆盖支架主体的移植材料。 该装置可以从具有小于容器直径的直径的压缩状态扩展至膨胀状态，至少与容器的直径一样大。 当处于压缩状态时，围绕该装置的护套包括护套主体和用于选择性地分离护套主体以允许器件膨胀的拉线。 该装置和封闭护套的尺寸适于插入通过损坏的壁部分进入容器，其中拉绳可延伸通过损坏的壁部分以分离护套主体。
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