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    Mitochondrial Aldehyde Dehydrogenase-2 Modulators and Methods of Use Thereof
    1.
    发明申请
    Mitochondrial Aldehyde Dehydrogenase-2 Modulators and Methods of Use Thereof 审中-公开
    线粒体醛脱氢酶-2调节剂及其使用方法

    公开(公告)号：US20110105602A2

    公开(公告)日：2011-05-05

    申请号：US12044870

    申请日：2008-03-07

    申请人： DARIA MOCHLY-ROSEN ,  Che-Hong Chen ,  Xiaohu Ouyang

    发明人： DARIA MOCHLY-ROSEN ,  Che-Hong Chen ,  Xiaohu Ouyang

    IPC分类号： A61K31/34 ,  C07D317/44

    CPC分类号： C07D317/58 ,  C07D405/12

    摘要： The present invention provides compounds that function as modulators of mitochondrial aldehyde dehydrogenase-2 (ALDH2) activity; and pharmaceutical compositions comprising the compounds. The present invention provides therapeutic methods involving administering a subject compound, or a subject pharmaceutical composition. The present invention further provides assays for identifying agonists of ALDH2.

    摘要翻译： 本发明提供作为线粒体醛脱氢酶-2（ALDH2）活性调节剂的化合物; 和包含该化合物的药物组合物。 本发明提供治疗方法，其包括给予主题化合物或主题药物组合物。 本发明还提供用于鉴定ALDH2激动剂的测定法。

    Methods and compositions for modulating mitochondrial aldehyde dehydrogenase-2
    4.
    发明申请
    Methods and compositions for modulating mitochondrial aldehyde dehydrogenase-2 失效
    调节线粒体醛脱氢酶-2的方法和组成

    公开(公告)号：US20050171043A1

    公开(公告)日：2005-08-04

    申请号：US11008482

    申请日：2004-12-08

    申请人： Daria Mochly-Rosen ,  Che-Hong Chen

    发明人： Daria Mochly-Rosen ,  Che-Hong Chen

    IPC分类号： A61K48/00 ,  C12Q1/32 ,  G01N33/50 ,  G01N33/566 ,  G01N33/573

    CPC分类号： G01N33/573 ,  G01N33/5008 ,  G01N33/566 ,  G01N2500/00

    摘要： The present invention provides screening methods for identifying agents that modulate the activity of mitochondrial aldehyde dehydrogenase-2 (AldDH2), as well as agents identified by the screening methods. The present invention further provides methods of reducing ischemic tissue damage or free-radical induced damage in an organ, the methods generally involving contacting the organ with an agent that increases AldDH2 levels and/or activity. The present invention further provides methods of treating solid tumors, the methods generally involving administering an agent that decreases AldDH2 levels and/or activity.

    摘要翻译： 本发明提供用于鉴定调节线粒体醛脱氢酶-2（AldDH2）的活性的试剂以及通过筛选方法鉴定的试剂的筛选方法。 本发明还提供了减少器官中缺血组织损伤或自由基诱导的损伤的方法，所述方法通常涉及使器官与增加AldDH2水平和/或活性的药剂接触。 本发明还提供治疗实体瘤的方法，所述方法通常涉及施用降低AldDH2水平和/或活性的药剂。

    Methods and compositions for modulating mitochondrial aldehyde dehydrogenase-2
    7.
    发明授权
    Methods and compositions for modulating mitochondrial aldehyde dehydrogenase-2 失效
    调节线粒体醛脱氢酶-2的方法和组成

    公开(公告)号：US07560241B2

    公开(公告)日：2009-07-14

    申请号：US11008482

    申请日：2004-12-08

    申请人： Daria Mochly-Rosen ,  Che-Hong Chen

    发明人： Daria Mochly-Rosen ,  Che-Hong Chen

    IPC分类号： G01N33/53 ,  G01N33/566

    CPC分类号： G01N33/573 ,  G01N33/5008 ,  G01N33/566 ,  G01N2500/00

    摘要： The present invention provides screening methods for identifying agents that modulate the activity of mitochondrial aldehyde dehydrogenase-2 (AldDH2), as well as agents identified by the screening methods. The present invention further provides methods of reducing ischemic tissue damage or free-radical induced damage in an organ, the methods generally involving contacting the organ with an agent that increases AldDH2 levels and/or activity. The present invention further provides methods of treating solid tumors, the methods generally involving administering an agent that decreases AldDH2 levels and/or activity.

    摘要翻译： 本发明提供用于鉴定调节线粒体醛脱氢酶-2（AldDH2）的活性的试剂以及通过筛选方法鉴定的试剂的筛选方法。 本发明还提供了减少器官中缺血组织损伤或自由基诱导的损伤的方法，所述方法通常涉及使器官与增加AldDH2水平和/或活性的药剂接触。 本发明还提供治疗实体瘤的方法，所述方法通常涉及施用降低AldDH2水平和/或活性的药剂。

    MITOCHONDRIAL ALDEHYDE DEHYDROGENASE-2 MODULATORS AND METHODS OF USE THEREOF
    8.
    发明申请
    MITOCHONDRIAL ALDEHYDE DEHYDROGENASE-2 MODULATORS AND METHODS OF USE THEREOF 审中-公开
    木糖醛酸脱氢酶-2调节剂及其使用方法

    公开(公告)号：US20090082431A1

    公开(公告)日：2009-03-26

    申请号：US12044870

    申请日：2008-03-07

    申请人： Daria Mochly-Rosen ,  Che-Hong Chen ,  Xiaohu Ouyang

    发明人： Daria Mochly-Rosen ,  Che-Hong Chen ,  Xiaohu Ouyang

    IPC分类号： A61K31/34 ,  C07D317/44

    CPC分类号： C07D317/58 ,  C07D405/12

    摘要： The present invention provides compounds that function as modulators of mitochondrial aldehyde dehydrogenase-2 (ALDH2) activity; and pharmaceutical compositions comprising the compounds. The present invention provides therapeutic methods involving administering a subject compound, or a subject pharmaceutical composition. The present invention further provides assays for identifying agonists of ALDH2.

    摘要翻译： 本发明提供作为线粒体醛脱氢酶-2（ALDH2）活性调节剂的化合物; 和包含该化合物的药物组合物。 本发明提供治疗方法，其包括给予主题化合物或主题药物组合物。 本发明还提供用于鉴定ALDH2激动剂的测定法。

    Crystal Structure of Aldehyde Dehydrogenase and Methods of Use Thereof
    10.
    发明申请
    Crystal Structure of Aldehyde Dehydrogenase and Methods of Use Thereof 审中-公开
    醛脱氢酶的晶体结构及其使用方法

    公开(公告)号：US20120028287A1

    公开(公告)日：2012-02-02

    申请号：US13270051

    申请日：2011-10-10

    申请人： Che-Hong CHEN ,  Daria MOCHLY-ROSEN ,  Thomas D. HURLEY

    发明人： Che-Hong CHEN ,  Daria MOCHLY-ROSEN ,  Thomas D. HURLEY

    IPC分类号： C12Q1/32 ,  G06F7/60 ,  G06G7/58 ,  C12N11/02

    CPC分类号： C12Y102/01004 ,  C07K2299/00 ,  C12Y102/01003 ,  G16C20/50

    摘要： The present disclosure provides a crystal structure of aldehyde dehydrogenase (ALDH) with a modulator of ALDH bound thereto. The present disclosure provides a computer readable medium comprising atomic coordinates for an ALDH polypeptide and a modulator bound to a site within the polypeptide. A method is also provided. In general terms, the method comprises computationally identifying a compound that binds to an ALDH polypeptide, using the atomic coordinates.

    摘要翻译： 本公开提供了与其结合的ALDH调节剂的醛脱氢酶（ALDH）的晶体结构。 本公开提供了包括ALDH多肽的原子坐标和与多肽内的位点结合的调节剂的计算机可读介质。 还提供了一种方法。 一般来说，该方法包括使用原子坐标计算上鉴定与ALDH多肽结合的化合物。