公开(公告)号：US10993335B1

公开(公告)日：2021-04-27

申请号：US16716514

申请日：2019-12-17

Applicant: Yun-Chang Tsui ,  Sampson Yang ,  Cheng-Han Yu

Inventor： Yun-Chang Tsui ,  Sampson Yang ,  Cheng-Han Yu

IPC: H05K5/00 ,  H05K5/03 ,  G06F1/16

Abstract: A clamping device for a protection casing of an electronic device serves to clamp a protection casing for receiving an electronic device. The protection casing includes an upper cover for covering an upper side of the electronic device and a lower cover for covering a lower side of the electronic device; and in assembly state, the upper cover is connected to the lower cover to enclose the electronic device. The clamping device comprises an upper clamping frame and a lower clamping frame for clamping the protection casing therein. A combining structure is arranged on lateral sides of the upper clamping frame and the lower clamping frame for combining the upper clamping frame and the lower clamping frame so that the upper clamping frame and the lower clamping frame clamp the protection casing tightly and thus the protection casing retains its function for a long time.

公开(公告)号：US20200333332A1

公开(公告)日：2020-10-22

申请号：US16847206

申请日：2020-04-13

Applicant: GEEN-DONG CHANG ,  MING-SHYUE LEE ,  CHENG-HAN YU

Inventor： GEEN-DONG CHANG ,  MING-SHYUE LEE ,  CHENG-HAN YU

IPC: G01N33/544 ,  G01N33/563 ,  G16B35/20 ,  A61K47/62 ,  A61K38/44 ,  A61K38/17 ,  A61K38/45

Abstract: Systems and methods to identify new protein targets of a chemical compound or its derivatives were described. The methods can be used for detection of new binding partners as long as the chemical compound can covalently bind to the protein targets. Once protein targets are resolved, information related to new protein targets can then be used to couple with real-world patient data such as adverse events, efficacy data, and disease correlation data to deduce real-world evidence. Systems collectively with all this information can aide clinical development and use of pharmaceutical drug. Methods are provided for detection of covalently bound phenyl vinyl sulfone (PVS) or its derivatives, and afatinib or its derivatives. Furthermore, generation of antiserum recognizing carrier bound PVS or carrier bound afatinib is described. PRMT1 is described as a new target of PVS and RRM1, RRM2, and NFKB are described as new targets of afatinib.

公开(公告)号：US20230118154A1

公开(公告)日：2023-04-20

申请号：US18067308

申请日：2022-12-16

Applicant: GEEN-DONG CHANG ,  MING-SHYUE LEE ,  CHENG-HAN YU

Inventor： GEEN-DONG CHANG ,  MING-SHYUE LEE ,  CHENG-HAN YU

IPC: G01N33/68 ,  G01N33/543

Abstract: Systems and methods to identify new protein targets of a chemical compound or its derivatives were described. The methods can be used for detection of new binding partners as long as the chemical compound can covalently bind to the protein targets. Once protein targets are resolved, information related to new protein targets can then be used to couple with real-world patient data such as adverse events, efficacy data, and disease correlation data to deduce real-world evidence. Systems collectively with all this information can aide clinical development and use of pharmaceutical drug. Methods are provided for detection of covalently bound phenyl vinyl sulfone (PVS) or its derivatives, and afatinib or its derivatives. Furthermore, generation of antiserum recognizing carrier bound PVS or carrier bound afatinib is described. PRMT1 is described as a new target of PVS and RRM1, RRM2, and NFKB are described as new targets of afatinib.

公开(公告)号：US20120326820A1

公开(公告)日：2012-12-27

申请号：US13480463

申请日：2012-05-24

Applicant: Cheng-Han YU ,  Yu-Chun LAI ,  Hsin-Wei Tsai

Inventor： Cheng-Han YU ,  Yu-Chun LAI ,  Hsin-Wei Tsai

IPC: H01F3/00

CPC classification number: H01F3/08 ,  H01F3/14 ,  H01F17/062 ,  H01F27/26 ,  H01F2003/106

Abstract: The disclosure discloses a magnetic unit, which includes a first ferrite core component, a second ferrite core component and a winding. There is a first hollow portion within the first ferrite core component. The second ferrite core component is disposed in the first hollow portion. There is a second hollow portion within the second ferrite core component. Magnetic saturation characteristics of the second ferrite core component are better than magnetic saturation characteristics of the first ferrite core component. The winding is wound on the first ferrite core component and the second ferrite core to component.

Abstract translation: 本公开公开了一种磁性单元，其包括第一铁氧体磁芯部件，第二铁氧体磁芯部件和绕组。 第一铁氧体磁芯组件内有第一中空部分。 第二铁氧体磁芯部件设置在第一中空部分中。 在第二铁氧体磁芯组件内有第二中空部分。 第二铁氧体磁芯组件的磁饱和特性优于第一铁氧体磁芯组件的磁饱和特性。 绕组缠绕在第一铁氧体芯部件上，第二铁氧体磁芯缠绕到部件上。