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公开(公告)号：US09254276B2
公开(公告)日：2016-02-09
申请号：US13357916
申请日：2012-01-25
申请人： Chengwu Li , Naohisa Yoshimi , Xincheng Hu , Shuang Li , Yunhua Gao
发明人： Chengwu Li , Naohisa Yoshimi , Xincheng Hu , Shuang Li , Yunhua Gao
IPC分类号： A61K9/127 , A61K31/19 , A61K31/198 , A61K31/203 , A61K31/215 , A61K31/375 , A61K31/704 , A61K8/14 , A61K8/55 , A61K8/60 , A61K8/67 , A61K8/92 , A61P17/00 , A61Q19/00 , A61K8/44 , A61K8/49 , A61K8/86 , A61K9/00 , A61K9/06
CPC分类号： A61K31/19 , A61K8/14 , A61K8/44 , A61K8/4946 , A61K8/4993 , A61K8/602 , A61K8/86 , A61K9/0014 , A61K9/06 , A61K9/1271 , A61K31/198 , A61K31/203 , A61K31/375 , A61K31/704 , A61K2800/10 , A61K2800/56 , A61Q19/00
摘要： A liposome comprising a phospholipid, a hydrophobic active comprising a carboxylate group, and a component selected from a group consisting of: a hydrophilic adjuvant comprising a positively charged group, a complex of said hydrophobic active with said hydrophilic adjuvant, and combinations thereof. An aqueous liposome dispersion comprising the liposome, and a personal care composition comprising the liposome. A process of preparing the liposome, comprising the steps of: forming a premix by dissolving a phospholipid, a hydrophobic active comprising a carboxylate group in an organic solvent; evaporating off said organic solvent from the premix to form a phospholipid film; and hydrating said lipid film with a hydration medium comprising a hydrophilic adjuvant comprising a positively charged group and homogenize the medium to form an aqueous liposome dispersion.
摘要翻译： 包含磷脂，包含羧酸酯基团的疏水性活性物质和选自以下的组分的脂质体：包含带正电基团的亲水性佐剂，所述疏水性活性物质与所述亲水性佐剂的配合物及其组合。 包含脂质体的脂质体水分散体和包含脂质体的个人护理组合物。 一种制备脂质体的方法，包括以下步骤：通过将磷脂，包含羧酸酯基团的疏水活性物质溶于有机溶剂中形成预混物; 从预混物中蒸发出所述有机溶剂以形成磷脂膜; 以及用包含带正电基团的亲水性佐剂的水合介质水合所述脂质膜，并均质培养基以形成脂质体水分散体。
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公开(公告)号：US20120189678A1
公开(公告)日：2012-07-26
申请号：US13357916
申请日：2012-01-25
申请人： Chengwu LI , Naohisa Yoshimi , Xincheng Hu , Shuang Li , Yunhua Gao
发明人： Chengwu LI , Naohisa Yoshimi , Xincheng Hu , Shuang Li , Yunhua Gao
IPC分类号： A61K9/127 , A61K31/215 , A61K31/704 , A61K31/198 , A61K31/203 , A61K8/67 , A61Q19/00 , A61P17/00 , A61K8/14 , A61K8/55 , A61K8/92 , A61K8/60 , A61K31/19 , A61K31/375
CPC分类号： A61K31/19 , A61K8/14 , A61K8/44 , A61K8/4946 , A61K8/4993 , A61K8/602 , A61K8/86 , A61K9/0014 , A61K9/06 , A61K9/1271 , A61K31/198 , A61K31/203 , A61K31/375 , A61K31/704 , A61K2800/10 , A61K2800/56 , A61Q19/00
摘要： A liposome comprising a phospholipid, a hydrophobic active comprising a carboxylate group, and a component selected from a group consisting of: a hydrophilic adjuvant comprising a positively charged group, a complex of said hydrophobic active with said hydrophilic adjuvant, and combinations thereof. An aqueous liposome dispersion comprising the liposome, and a personal care composition comprising the liposome. A process of preparing the liposome, comprising the steps of: forming a premix by dissolving a phospholipid, a hydrophobic active comprising a carboxylate group in an organic solvent; evaporating off said organic solvent from the premix to form a phospholipid film; and hydrating said lipid film with a hydration medium comprising a hydrophilic adjuvant comprising a positively charged group and homogenize the medium to form an aqueous liposome dispersion.
摘要翻译： 包含磷脂，包含羧酸酯基团的疏水性活性物质和选自以下的组分的脂质体：包含带正电基团的亲水性佐剂，所述疏水性活性物质与所述亲水性佐剂的配合物及其组合。 包含脂质体的脂质体水分散体和包含脂质体的个人护理组合物。 一种制备脂质体的方法，包括以下步骤：通过将磷脂，包含羧酸酯基团的疏水活性物质溶于有机溶剂中形成预混物; 从预混物中蒸发出所述有机溶剂以形成磷脂膜; 以及用包含带正电基团的亲水性佐剂的水合介质水合所述脂质膜，并均质培养基以形成脂质体水分散体。
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公开(公告)号：US20110105406A1
公开(公告)日：2011-05-05
申请号：US12915381
申请日：2010-10-29
申请人： Chengwu Li , Xincheng Hu
发明人： Chengwu Li , Xincheng Hu
CPC分类号： A61Q19/00 , A61K8/44 , A61K8/4926 , A61K8/675 , A61K8/731 , A61K8/735 , A61K2800/262
摘要： The present invention relates to a cosmetic composition comprising: a) from about 0.05% to about 10% of a salt form active; b) from about 0.001% to about 2% of a thickening agent; and c) water, wherein the composition has a turbidity no higher than about 10 NTU, and has a pH in the range of about 5.0 to about 6.8.
摘要翻译： 本发明涉及化妆品组合物，其包含：a）约0.05％至约10％的活性盐形式; b）约0.001％至约2％的增稠剂; 和c）水，其中所述组合物的浊度不高于约10NTU，并且pH在约5.0至约6.8的范围内。
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