公开(公告)号：US09254276B2

公开(公告)日：2016-02-09

申请号：US13357916

申请日：2012-01-25

申请人： Chengwu Li ,  Naohisa Yoshimi ,  Xincheng Hu ,  Shuang Li ,  Yunhua Gao

发明人： Chengwu Li ,  Naohisa Yoshimi ,  Xincheng Hu ,  Shuang Li ,  Yunhua Gao

IPC分类号： A61K9/127 ,  A61K31/19 ,  A61K31/198 ,  A61K31/203 ,  A61K31/215 ,  A61K31/375 ,  A61K31/704 ,  A61K8/14 ,  A61K8/55 ,  A61K8/60 ,  A61K8/67 ,  A61K8/92 ,  A61P17/00 ,  A61Q19/00 ,  A61K8/44 ,  A61K8/49 ,  A61K8/86 ,  A61K9/00 ,  A61K9/06

CPC分类号： A61K31/19 ,  A61K8/14 ,  A61K8/44 ,  A61K8/4946 ,  A61K8/4993 ,  A61K8/602 ,  A61K8/86 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/1271 ,  A61K31/198 ,  A61K31/203 ,  A61K31/375 ,  A61K31/704 ,  A61K2800/10 ,  A61K2800/56 ,  A61Q19/00

摘要： A liposome comprising a phospholipid, a hydrophobic active comprising a carboxylate group, and a component selected from a group consisting of: a hydrophilic adjuvant comprising a positively charged group, a complex of said hydrophobic active with said hydrophilic adjuvant, and combinations thereof. An aqueous liposome dispersion comprising the liposome, and a personal care composition comprising the liposome. A process of preparing the liposome, comprising the steps of: forming a premix by dissolving a phospholipid, a hydrophobic active comprising a carboxylate group in an organic solvent; evaporating off said organic solvent from the premix to form a phospholipid film; and hydrating said lipid film with a hydration medium comprising a hydrophilic adjuvant comprising a positively charged group and homogenize the medium to form an aqueous liposome dispersion.

摘要翻译： 包含磷脂，包含羧酸酯基团的疏水性活性物质和选自以下的组分的脂质体：包含带正电基团的亲水性佐剂，所述疏水性活性物质与所述亲水性佐剂的配合物及其组合。 包含脂质体的脂质体水分散体和包含脂质体的个人护理组合物。 一种制备脂质体的方法，包括以下步骤：通过将磷脂，包含羧酸酯基团的疏水活性物质溶于有机溶剂中形成预混物; 从预混物中蒸发出所述有机溶剂以形成磷脂膜; 以及用包含带正电基团的亲水性佐剂的水合介质水合所述脂质膜，并均质培养基以形成脂质体水分散体。

公开(公告)号：US08384374B2

公开(公告)日：2013-02-26

申请号：US12742925

申请日：2008-11-12

申请人： Yunhua Gao

发明人： Yunhua Gao

IPC分类号： G01N27/74 ,  G01R33/12

CPC分类号： G01N27/72

摘要： An apparatus for automatically testing CMOS magnetoresistive biochips is disclosed. The apparatus includes: means for directly or indirectly applying physical pressure to the fluid pumping chamber in a cartridge; a liquid injector for injecting liquid into the reaction chamber in the cartridge through an inlet or inlets in fluid connection to said reaction chamber; a CMOS magnetoresistive biochip located in the reaction chamber in the cartridge; means for applying a magnetic field to said CMOS magnetoresistive biochip in the cartridge; an electronic module for communicating with and supplying power as well as control signals to said biochip; a microprocessor to control and coordinate the aforementioned components; and a user interface for information processing. The apparatus provided by the present invention reduces the complexity of operation and enhances the detection sensitivity to a great extent.

摘要翻译： 公开了一种用于自动测试CMOS磁阻生物芯片的设备。 该装置包括：用于直接或间接地向筒中的流体泵送室施加物理压力的装置; 液体注射器，用于通过流体连接到所述反应室的入口或入口将液体注入到所述反应室中; 位于墨盒中的反应室中的CMOS磁阻生物芯片; 用于向所述盒中的所述CMOS磁阻生物芯片施加磁场的装置; 用于与所述生物芯片通信并提供电力以及控制信号的电子模块; 控制和协调上述组件的微处理器; 和用于信息处理的用户界面。 本发明提供的装置降低了操作的复杂性，并且在很大程度上提高了检测灵敏度。

公开(公告)号：US20120189678A1

公开(公告)日：2012-07-26

申请号：US13357916

申请日：2012-01-25

申请人： Chengwu LI ,  Naohisa Yoshimi ,  Xincheng Hu ,  Shuang Li ,  Yunhua Gao

发明人： Chengwu LI ,  Naohisa Yoshimi ,  Xincheng Hu ,  Shuang Li ,  Yunhua Gao

IPC分类号： A61K9/127 ,  A61K31/215 ,  A61K31/704 ,  A61K31/198 ,  A61K31/203 ,  A61K8/67 ,  A61Q19/00 ,  A61P17/00 ,  A61K8/14 ,  A61K8/55 ,  A61K8/92 ,  A61K8/60 ,  A61K31/19 ,  A61K31/375

CPC分类号： A61K31/19 ,  A61K8/14 ,  A61K8/44 ,  A61K8/4946 ,  A61K8/4993 ,  A61K8/602 ,  A61K8/86 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/1271 ,  A61K31/198 ,  A61K31/203 ,  A61K31/375 ,  A61K31/704 ,  A61K2800/10 ,  A61K2800/56 ,  A61Q19/00

摘要： A liposome comprising a phospholipid, a hydrophobic active comprising a carboxylate group, and a component selected from a group consisting of: a hydrophilic adjuvant comprising a positively charged group, a complex of said hydrophobic active with said hydrophilic adjuvant, and combinations thereof. An aqueous liposome dispersion comprising the liposome, and a personal care composition comprising the liposome. A process of preparing the liposome, comprising the steps of: forming a premix by dissolving a phospholipid, a hydrophobic active comprising a carboxylate group in an organic solvent; evaporating off said organic solvent from the premix to form a phospholipid film; and hydrating said lipid film with a hydration medium comprising a hydrophilic adjuvant comprising a positively charged group and homogenize the medium to form an aqueous liposome dispersion.

摘要翻译： 包含磷脂，包含羧酸酯基团的疏水性活性物质和选自以下的组分的脂质体：包含带正电基团的亲水性佐剂，所述疏水性活性物质与所述亲水性佐剂的配合物及其组合。 包含脂质体的脂质体水分散体和包含脂质体的个人护理组合物。 一种制备脂质体的方法，包括以下步骤：通过将磷脂，包含羧酸酯基团的疏水活性物质溶于有机溶剂中形成预混物; 从预混物中蒸发出所述有机溶剂以形成磷脂膜; 以及用包含带正电基团的亲水性佐剂的水合介质水合所述脂质膜，并均质培养基以形成脂质体水分散体。

公开(公告)号：US08323573B2

公开(公告)日：2012-12-04

申请号：US12747889

申请日：2008-12-12

申请人： Yunhua Gao

发明人： Yunhua Gao

IPC分类号： G01N27/00

CPC分类号： B01L3/502715 ,  B01L3/50273 ,  B01L2200/16 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2400/0478 ,  B01L2400/0633 ,  G01N27/745 ,  G01N2035/1034 ,  Y10T137/085 ,  Y10T137/2202 ,  Y10T137/2218 ,  Y10T137/7837 ,  Y10T137/9029

摘要： A microfluidic cartridge with solution reservoir-pump chamber is disclosed. The microfluidic cartridge comprises a channel-chamber layer, a sealing layer, a printed circuit board bound with magnetoresistive biochip. The channel-chamber layer includes at least a waste reservoir, a reaction-detection chamber, a solution reservoir-pump chamber and a plurality of micro-channels. Said solution reservoir-pump chamber realizes both functions of solution reservoir and pump chamber in a single structure. Said sealing layer is sealed with said channel-chamber layer to form an integrated microfluidic system with at least a waste reservoir, a reaction-detection chamber, a solution inlet, a solution reservoir-pump chamber and a micro-channel. Said solution reservoir-pump chamber in the present invention consists of elastic objects inside for sealing and pumping. Under pressure, said elastic object propels solution in the reservoir into said reaction-detection chamber via channels of said plurality of micro-channels.

摘要翻译： 公开了一种具有溶液储层泵室的微流体筒。 微流控盒包括通道室层，密封层，与磁阻生物芯片结合的印刷电路板。 通道室层至少包括废物储存器，反应检测室，溶液储存器 - 泵室和多个微通道。 所述溶液储层泵室在单一结构中实现了溶液储层和泵室的功能。 所述密封层用所述通道室层密封以形成至少具有废物储存器，反应检测室，溶液入口，溶液储存器 - 泵室和微通道的集成微流体系统。 本发明的所述溶液储层泵室由用于密封和泵送的弹性物体组成。 在压力下，所述弹性物体通过所述多个微通道的通道推动储存器中的溶液进入所述反应检测室。

公开(公告)号：US20110035176A1

公开(公告)日：2011-02-10

申请号：US12742925

申请日：2008-11-12

申请人： Yunhua Gao

发明人： Yunhua Gao

IPC分类号： G06F19/00 ,  G01R31/00

CPC分类号： G01N27/72

摘要： An apparatus for automatically testing CMOS magnetoresistive biochips is disclosed. The apparatus includes: means for directly or indirectly applying physical pressure to the fluid pumping chamber in a cartridge; a liquid injector for injecting liquid into the reaction chamber in the cartridge through an inlet or inlets in fluid connection to said reaction chamber; a CMOS magnetoresistive biochip located in the reaction chamber in the cartridge; means for applying a magnetic field to said CMOS magnetoresistive biochip in the cartridge; an electronic module for communicating with and supplying power as well as control signals to said biochip; a microprocessor to control and coordinate the aforementioned components; and a user interface for information processing. The apparatus provided by the present invention reduces the complexity of operation and enhances the detection sensitivity to a great extent.

摘要翻译： 公开了一种用于自动测试CMOS磁阻生物芯片的设备。 该装置包括：用于直接或间接地向筒中的流体泵送室施加物理压力的装置; 液体注射器，用于通过流体连接到所述反应室的入口或入口将液体注入到所述反应室中; 位于墨盒中的反应室中的CMOS磁阻生物芯片; 用于向所述盒中的所述CMOS磁阻生物芯片施加磁场的装置; 用于与所述生物芯片通信并提供电力以及控制信号的电子模块; 控制和协调上述组件的微处理器; 和用于信息处理的用户界面。 本发明提供的装置降低了操作的复杂性，并且在很大程度上提高了检测灵敏度。

公开(公告)号：US20110020182A1

公开(公告)日：2011-01-27

申请号：US12747889

申请日：2008-12-12

申请人： Yunhua Gao

发明人： Yunhua Gao

IPC分类号： G01N27/00

CPC分类号： B01L3/502715 ,  B01L3/50273 ,  B01L2200/16 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2400/0478 ,  B01L2400/0633 ,  G01N27/745 ,  G01N2035/1034 ,  Y10T137/085 ,  Y10T137/2202 ,  Y10T137/2218 ,  Y10T137/7837 ,  Y10T137/9029

摘要： A microfluidic cartridge with solution reservoir-pump chamber is disclosed. The microfluidic cartridge comprises a channel-chamber layer, a sealing layer, a printed circuit board bound with magnetoresistive biochip. The channel-chamber layer includes at least a waste reservoir, a reaction-detection chamber, a solution reservoir-pump chamber and a plurality of micro-channels. Said solution reservoir-pump chamber realizes both functions of solution reservoir and pump chamber in a single structure. Said sealing layer is sealed with said channel-chamber layer to form an integrated microfluidic system with at least a waste reservoir, a reaction-detection chamber, a solution inlet, a solution reservoir-pump chamber and a micro-channel. Said solution reservoir-pump chamber in the present invention consists of elastic objects inside for sealing and pumping. Under pressure, said elastic object propels solution in the reservoir into said reaction-detection chamber via channels of said plurality of micro-channels.

摘要翻译： 公开了一种具有溶液储层泵室的微流体筒。 微流控盒包括通道室层，密封层，与磁阻生物芯片结合的印刷电路板。 通道室层至少包括废物储存器，反应检测室，溶液储存器 - 泵室和多个微通道。 所述溶液储层泵室在单一结构中实现了溶液储层和泵室的功能。 所述密封层用所述通道室层密封以形成至少具有废物储存器，反应检测室，溶液入口，溶液储存器 - 泵室和微通道的集成微流体系统。 本发明的所述溶液储层泵室由用于密封和泵送的弹性物体组成。 在压力下，所述弹性物体通过所述多个微通道的通道推动储存器中的溶液进入所述反应检测室。