公开(公告)号：US5962012A

公开(公告)日：1999-10-05

申请号：US22308

申请日：1998-02-11

Applicant: Wan-Yan Lin ,  Shu-Juan Chen ,  Chao-Wei Liao ,  Chien-Hsin D. Cheng

Inventor： Wan-Yan Lin ,  Shu-Juan Chen ,  Chao-Wei Liao ,  Chien-Hsin D. Cheng

IPC: A61K9/70 ,  A61K31/439 ,  A61K31/46 ,  A61K47/14 ,  A61K47/18 ,  A61F13/02

CPC classification number: A61K9/7061 ,  A61K31/439 ,  A61K31/46 ,  A61K47/18 ,  A61K9/0014 ,  Y10S514/946 ,  Y10S514/947

Abstract: Scopolamine is a folksy cholinergic antagonist, and is used by parasympathetic nerves in autonomic nervous neurons as an anti-motion sickness drug or an anti-emesis drug. Since the human body most effectively absorbs this drug through the postauricular skin, the drug is administered by postauricular transdermal resorption patch. The penetrability of drug is increase by adding a dermal penetrative enhancer, because the penetration ability of patch-administered drugs is usually decreased by the penetrative blockade at dermal horny layers. The present invention discloses a penetration enhancer to increase dermal absorption and penetration of the cholinergic antagonist. The present invention finds that polyethylene and amide enhance penetration, about 2.2-2.8 fold. In accordance with the present invention, a penetration enhancer is added to the formulations of transdermal patch to increase the human body's absorption of scopolamine.

Abstract translation: 东莨菪碱是一种民族胆碱能拮抗剂，由自主神经神经元中的副交感神经用作抗运动疾病药物或抗呕吐药物。 由于人体最有效地通过耳后皮肤吸收该药物，所以该药物通过耳后皮肤吸收贴片施用。 通过添加皮肤渗透性增强剂，药物的渗透性增加，因为补片施用药物的穿透能力通常通过在真皮角质层上的穿透性阻断而降低。 本发明公开了一种增加胆碱能拮抗剂的皮肤吸收和渗透的渗透促进剂。 本发明发现聚乙烯和酰胺增强渗透性，约2.2-2.8倍。 根据本发明，将渗透增强剂加入透皮贴剂的制剂中以增加人体对东莨菪碱的吸收。

公开(公告)号：US6159493A

公开(公告)日：2000-12-12

申请号：US21965

申请日：1998-02-11

Applicant: Shu-Juan Chen ,  Chao-Wei Liao ,  Chien-Hsin D. Cheng

Inventor： Shu-Juan Chen ,  Chao-Wei Liao ,  Chien-Hsin D. Cheng

IPC: A61K8/02 ,  A61K9/70 ,  A61K31/765 ,  A61K31/79 ,  A61Q19/00

CPC classification number: A61Q19/00 ,  A61K31/765 ,  A61K31/79 ,  A61K8/0208 ,  A61K9/7023 ,  Y10S514/859

Abstract: A formulation and a method for manufacturing an acne extraction patch. Water is added into polyvinyl alcohol and polyvinyl pyrrolidone to form an polymer solution. An adequate excipient is further added to form an optimal formulation. The formulation is coated directly onto the hydrophilic nonwovens or the nonwovens are placed over the release liner after coating the release liner with silicon coating. After the steps described above, the nonwovens are put into the dry oven for a two-step drying method at 55-90.degree. C., and 80-95.degree. C. A die-cut and package machine is used to cut an adequate patch. The patch is moistened with water and applied to the face or nose. The water solution of the formulation penetrates into the hair follicles or sebaceous glands. The lug of acne sticks to the polymer patch as the water evaporates. The acne is extracted from the hair follicle as the patch is removed.

Abstract translation: 用于制造痤疮提取补片的制剂和方法。 将水加入到聚乙烯醇和聚乙烯吡咯烷酮中以形成聚合物溶液。 进一步加入足够的赋形剂以形成最佳配方。 将制剂直接涂布在亲水性无纺布上，或者在用硅涂层涂布剥离衬垫之后，将非织造布放置在剥离衬垫上。 在上述步骤之后，将无纺布在55-90℃和80-95℃下放入干燥炉中进行两步干燥方法。使用模切和包装机切割适当的贴剂 。 贴片用水润湿并涂抹于脸部或鼻子上。 制剂的水溶液渗入毛囊或皮脂腺。 当水蒸发时，痤疮的耳朵粘在聚合物贴片上。 当补片被去除时，从毛囊中提取痤疮。

公开(公告)号：US5420182A

公开(公告)日：1995-05-30

申请号：US191011

申请日：1994-02-01

Applicant: Rong-Shuh Chang ,  Tsai-Wie Tseng ,  Shinn-Jen Chang ,  Chien-Hsin D. Cheng

Inventor： Rong-Shuh Chang ,  Tsai-Wie Tseng ,  Shinn-Jen Chang ,  Chien-Hsin D. Cheng

IPC: C08F8/30 ,  C08K5/20 ,  C08K5/3415 ,  C08K5/053 ,  C08K5/09

CPC classification number: C08K5/20 ,  C08F8/30 ,  C08K5/3415

Abstract: A water retaining adhesive composition prepared by polymerizing and partially crosslinking 100 parts by weight of a 20 to 35 wt % solution of the acrylic polymer with 2 to 5 parts by weight of the amine group compound, amide group compound or amino group compound at a temperature of 20.degree. C. to 80.degree. C.; adjusting the pH value of the resultant partially crosslinked polymer to 6.0 to 7.0; and then sequentially compounding 10 to 40 parts by weight of modifiers and 2 to 5 parts by weight of water retaining agent in the partially crosslinked polymer. The modifier is a polyol, a polyalcohol or a poly(ether alcohol). The water retaining agent is 2-pyrrolidone-5-carboxylate.

Abstract translation: 一种保水粘合剂组合物，其通过聚合和部分交联100重量份的丙烯酸类聚合物的20-35重量％的溶液和2-5重量份的胺基化合物，酰胺基化合物或氨基化合物，在温度 20℃至80℃。 将所得部分交联的聚合物的pH值调节至6.0至7.0; 然后在部分交联的聚合物中顺序混合10至40重量份的改性剂和2至5重量份的保水剂。 改性剂是多元醇，多元醇或聚（醚醇）。 保水剂是2-吡咯烷酮-5-羧酸酯。