公开(公告)号：US07033788B2

公开(公告)日：2006-04-25

申请号：US10089473

申请日：2002-03-26

Applicant: Kwang-Hoe Chung ,  Doo-sik Kim ,  Sung-Yu Hong ,  You-Seok Koh ,  Young-Doug Sohn ,  Weon-Kyoo You ,  Yang-Soo Jang ,  Chin-Kyu Huh

Inventor： Kwang-Hoe Chung ,  Doo-sik Kim ,  Sung-Yu Hong ,  You-Seok Koh ,  Young-Doug Sohn ,  Weon-Kyoo You ,  Yang-Soo Jang ,  Chin-Kyu Huh

IPC: C12N15/12 ,  C12N15/63 ,  C12N1/19 ,  C12N1/00 ,  A61K38/17

CPC classification number: C07K14/745 ,  A61K38/00 ,  C07K14/46

Abstract: The present invention relates to Saxatilin, a protein derived from the venom of a Korean snake, Agkistrodon saxatilis emelianov, a process for preparing Saxatilin, and pharmaceutical application of the same as anti-platelet aggregation agent and anti-tumor agent. The present inventors purified Saxatilin from the venom of Agkistrodon saxatilis emelianov, cloned its cDNA, and prepared recombinant Saxatilin by culturing a microorganism transformed with an expression vector containing the cDNA. Saxatilin effectively suppresses the platelet aggregation and angiogenesis of tumor cells, which makes possible its practical application as an active ingredient of anti-platelet agent and anti-tumor agent.

Abstract translation: 本发明涉及萨克西林，一种衍生自韩国蛇的毒液，猕猴桃，猕猴桃，一种制备萨克西林的方法，以及其抗血小板聚集剂和抗肿瘤剂的药物应用。 本发明人从猕猴桃痘病毒的毒液中纯化了萨克西林，克隆了其cDNA，并通过培养用含有cDNA的表达载体转化的微生物来制备重组萨克斯汀。 萨克西汀有效抑制肿瘤细胞的血小板聚集和血管生成，使其作为抗血小板剂和抗肿瘤剂的有效成分成为可能。

公开(公告)号：US20050032189A1

公开(公告)日：2005-02-10

申请号：US10089473

申请日：2002-03-26

Applicant: Kwang-Hoe Chung ,  Doo-Sik Kim ,  Sung-Yu Hong ,  You-Seok Koh ,  Young-Doug Sohn ,  Weon-Kyoo You ,  Yang-Soo Jang ,  Chin-Kyu Huh

Inventor： Kwang-Hoe Chung ,  Doo-Sik Kim ,  Sung-Yu Hong ,  You-Seok Koh ,  Young-Doug Sohn ,  Weon-Kyoo You ,  Yang-Soo Jang ,  Chin-Kyu Huh

IPC: C12N15/09 ,  A61K38/00 ,  A61P7/02 ,  A61P35/00 ,  C07K1/16 ,  C07K14/46 ,  C07K14/745 ,  C12N1/19 ,  C12P21/02 ,  C12R1/84 ,  C12N9/64 ,  A61K38/46 ,  C07H21/04 ,  C12N1/18 ,  C12N15/74

CPC classification number: C07K14/745 ,  A61K38/00 ,  C07K14/46

Abstract: The present invention relates to Saxatilin, a protein derived from the venom of a Korean snake, Agkistrodon saxatilis emelianov, a process for preparing Saxatilin, and pharmaceutical application of the same as anti-platelet aggregation agent and anti-tumor agent. The present inventors purified Saxatilin from the venom of Agkistrodon saxatilis emelianov, cloned its cDNA, and prepared recombinant Saxatilin by culturing a microorganism transformed with an expression vector containing the cDNA. Saxatilin effectively suppresses the platelet aggregation and angiogenesis of tumor cells, which makes possible its practical application as an active ingredient of anti-platelet agent and anti-tumor agent.

Abstract translation: 本发明涉及萨克西林，一种衍生自韩国蛇的毒液，猕猴桃，猕猴桃，一种制备萨克西林的方法，以及其抗血小板聚集剂和抗肿瘤剂的药物应用。 本发明人从猕猴桃痘病毒的毒液中纯化了萨克西林，克隆了其cDNA，并通过培养用含有cDNA的表达载体转化的微生物来制备重组萨克斯汀。 萨克西汀有效抑制肿瘤细胞的血小板聚集和血管生成，使其作为抗血小板剂和抗肿瘤剂的有效成分成为可能。

公开(公告)号：US06236799B1

公开(公告)日：2001-05-22

申请号：US09324917

申请日：1999-06-03

Applicant: Chin-kyu Huh ,  Sang-yong Han ,  Si-ken Lee ,  Jae-eun Yoo

Inventor： Chin-kyu Huh ,  Sang-yong Han ,  Si-ken Lee ,  Jae-eun Yoo

IPC: G02B600

CPC classification number: G02F1/011 ,  G02F1/1326 ,  Y10S385/901

Abstract: A flat-panel display device using an optical waveguide includes a light source for emitting light, a plurality of optical waveguides into which light emitted from the light source is incident, an optical waveguide arrangement substrate on which the plurality of optical waveguides are arranges and made of a material having a low refractive index so as to totally reflect the light transmitted through the plurality of optical waveguides, a light output controller positioned on the plurality of optical waveguides and made of a material whose refractive index changes according to an electric field, a light output portion positioned on the light output controller, for refracting the light having passed through the light output controller when the light propagated through the plurality of optical waveguides due to the electric field is transmitted through the light output controller and is output therefrom, and outputting the same to the outside, a first electrode positioned on the light output portion, made of a transparent conductive material, and to which a predetermined control voltage is applied, a second electrode positioned under the light output controller, made of a conductive material, and which forms an electric field in conjunction with the first electrode, and a driver for applying the predetermined control voltage to the first and second electrodes. Therefore, the resolution of a reproduced image can be greatly enhanced, the light efficiency is very high and the viewing angle is increased.

Abstract translation: 使用光波导的平板显示装置包括用于发光的光源，从光源发射的光入射到其上的多个光波导，配置有多个光波导的光波导配置基板 具有低折射率的材料以便完全反射透过多个光波导的光;光输出控制器，其位于多个光波导上，并且由折射率根据电场变化的材料制成， 位于光输出控制器上的光输出部分，当由于电场传播通过多个光波导的光被透射通过光输出控制器并从其输出时，用于折射已经通过光输出控制器的光，并输出 与外部相同，位于光源外的第一电极 由透明导电材料制成，并且施加预定控制电压的第二电极，位于光输出控制器下方的由导电材料制成并与第一电极结合形成电场的第二电极，以及 用于将预定控制电压施加到第一和第二电极的驱动器。 因此，可以大大提高再现图像的分辨率，光效率非常高，视角增大。