Substituted (alkoxycarbonylthioureido)-(acylamino)-benzene derivatives
    5.
    发明授权
    Substituted (alkoxycarbonylthioureido)-(acylamino)-benzene derivatives 失效
    取代的(烷氧基羰基硫脲基) - (酰氨基) - 苯衍生物

    公开(公告)号:US4034107A

    公开(公告)日:1977-07-05

    申请号:US628669

    申请日:1975-11-04

    摘要: Benzene derivatives of the formula: ##STR1## wherein R.sup.1 represents alkyl, R.sup.2 represents a group --SR.sup.3, --SOR.sup.3, --SO.sub.2 R.sup.3, --OR.sup.3, --SCONH.sub.2, --SCN or --T(CH.sub.2).sub.m T.sup.1 R.sup.4 [wherein R.sup.3 represeents alkyl, cycloalkyl, alkenyl, alkynyl, aralkyl, unsubstituted or substituted aryl, or cycloalkylalkyl, R.sup.4 represents hydrogen or alkyl, T and T.sup.1 each represent oxygen, sulphur or sulphinyl, and m is an integer from 1 to 7] whose position on the benzene ring is either para to the group --NHCSNHCOOR.sup.1 or para to the group --NHCOAZ, A represents a bivalent straight-chain aliphatic hydrocarbon radical of 1 to 4 carbon atoms or a said hydrocarbon radical substituted by at least one methyl group, and Z represents a group of the formula:- ##STR2## wherein R.sup.5 represents hydrogen or alkyl, R.sup.6 represents hydrogen, alkyl or phenylalkyl, and R.sup.7 represents hydrogen or alkyl, or R.sup.6 and R.sup.7 together with the nitrogen atom to which they are attached form a 5-,6- or 7-membered heterocyclic ring optionally substituted by alkyl group(s), and X.sup.- represents a pharmaceutically acceptable anion, are new compounds useful as anthelmintics and antifungal agents.

    摘要翻译: 下式的苯衍生物:其中R1代表烷基,R2代表基团-SR3,-SOR3,-SO2R3,-OR3,-SCONH2,-SCN或-T(CH2)mT1R4 [其中R3代表烷基,环烷基 ,烯基,炔基,芳烷基,未取代或取代的芳基或环烷基烷基,R 4表示氢或烷基,T和T1各自表示氧,硫或亚磺酰基,m是1至7的整数],其在苯环上的位置是 基团-NHCSNHCOOR1的对位或基团-NHCOAZ的对位,A表示1至4个碳原子的二价直链脂族烃基或被至少一个甲基取代的所述烃基,Z表示 式:其中R 5表示氢或烷基,R 6表示氢,烷基或苯基烷基,R 7表示氢或烷基,或者R 6和R 7与它们所连接的氮原子一起形成5-,6-或 任选被烷基取代的7元杂环, ,X'表示药学上可接受的阴离子,是可用作驱肠虫剂和抗真菌剂的新化合物。