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1.发明授权Method and apparatus for electrostatically depositing a medicament powder upon predefined regions of a substrate 失效用于将药物粉末静电沉积在基底的预定区域上的方法和装置公开(公告)号：US06319541B1
公开(公告)日：2001-11-20
申请号：US09475453
申请日：1999-12-30
IPC分类号： B05D106
CPC分类号： A61K9/0075 , A61J3/00 , A61K9/0073 , A61M15/0045 , A61M15/0048 , A61M15/02 , A61M15/025 , B05B5/025 , B05B5/047 , G03G15/04045 , G03G15/221 , G03G15/323
摘要： A method for electrostatically depositing select doses of medicament powder at select locations on a substrate. Specifically, an apparatus contains a charged particle emitter for generating charged particles that charge a predefined region of a substrate and a charge accumulation control circuit for computing the amount of charge accumulated upon the substrate and deactivating the emitter when a selected quantity of charge has accumulated. Additionally, a triboelectric charging apparatus charges the medicament powder and forms a charged medicament cloud proximate the charged region of the substrate. The medicament particles within the medicament cloud electrostatically adhere to the charged region. The quantity of charge accumulated on the substrate at the predefined region and the charge-to-mass ratio of the medicament powder in the cloud control the amount (dose) of medicament deposited and retained by the substrate. Consequently, this apparatus accurately controls both medicament dosage and deposition location. Furthermore, since the substrate can be of any dielectric material that retains an electrostatic charge, the apparatus can be used to deposit medicament on substrates that are presently used in oral medicament consumption, e.g., substrates that are used to fabricate suppositories, inhalants, tablets, capsules and the like.
摘要翻译： 一种用于在基底上的选定位置静电沉积药物粉末的方法。 具体地，装置包含用于产生对基板的预定区域充电的带电粒子的带电粒子发射器和用于计算在基板上累积的电荷量并且在已选择的电荷积累时停用发射极的电荷累积控制电路。 此外，摩擦带电装置对药物粉末进行充电，并在基底的带电区域附近形成带电药物云。 药物云内的药物颗粒静电附着到带电区域。 在预定区域上积累在基底上的电荷量和云中的药物粉末的电荷与质量比控制由基底沉积和保留的药物的量（剂量）。 因此，该装置精确地控制药物剂量和沉积位置。 此外，由于衬底可以是保持静电电荷的任何电介质材料，所以该装置可用于在目前用于口服药物消耗的基底上沉积药物，例如用于制造栓剂，吸入剂，片剂， 胶囊等。
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2.发明授权Method for electrostatically depositing a medicament powder upon predefined regions of a substrate 失效将药物粉末静电沉积在基材的预定区域上的方法
公开(公告)号：US6074688A
公开(公告)日：2000-06-13
申请号：US733525
申请日：1996-10-18
IPC分类号： A61J3/02 , A61J3/00 , A61K9/00 , A61M11/00 , A61M15/00 , A61M15/02 , B05B5/00 , B05B5/025 , B05B5/03 , B05B5/047 , B05B5/08 , G03G15/22 , G03G15/32 , B05D1/06 , B05D3/14
CPC分类号： A61K9/0075 , A61J3/00 , A61K9/0073 , A61M15/0045 , A61M15/0048 , A61M15/025 , B05B5/025 , B05B5/047 , G03G15/04045 , G03G15/221 , G03G15/323 , A61M15/02
摘要： Method for electrostatically depositing select doses of medicament powder at select locations on a substrate. Specifically, the apparatus contains a charged particle emitter for generating charged particles that charge a predefined region of a substrate and a charge accumulation control circuit for computing the amount of charge accumulated upon the substrate and deactivating the emitter when a selected quantity of charge has accumulated. Additionally, a triboelectric charging apparatus charges the medicament powder and forms a charged medicament cloud proximate the charged region of the substrate. The medicament particles within the medicament cloud electrostatically adhere to the charged region. The quantity of charge accumulated on the substrate at the predefined region and the charge-to-mass ratio of the medicament powder in the cloud control the amount (dose) of medicament deposited and retained by the substrate. Consequently, this apparatus accurately controls both medicament dosage and deposition location. Furthermore, since the substrate can be of any dielectric material that retains an electrostatic charge, the apparatus can be used to deposit medicament on substrates that are presently used in oral medicament consumption, e.g., substrates that are used to fabricate suppositories, inhalants, tablets, capsules and the like.
摘要翻译： 将选择剂量的药物粉末静电沉积在基底上的选定位置的方法。 具体地，该装置包含用于产生对基板的预定区域充电的带电粒子的带电粒子发射器和用于计算在基板上累积的电荷量并且在已选择的电荷积累时停用发射极的电荷累积控制电路。 此外，摩擦带电装置对药物粉末进行充电，并在基底的带电区域附近形成带电药物云。 药物云内的药物颗粒静电附着到带电区域。 在预定区域上积累在基底上的电荷量和云中的药物粉末的电荷与质量比控制由基底沉积和保留的药物的量（剂量）。 因此，该装置精确地控制药物剂量和沉积位置。 此外，由于衬底可以是保持静电电荷的任何电介质材料，所以该装置可用于在目前用于口服药物消耗的基底上沉积药物，例如用于制造栓剂，吸入剂，片剂， 胶囊等。
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3.发明授权Method and apparatus for electrostatically depositing a medicament powder upon predefined regions of a substrate 失效用于将药物粉末静电沉积在基底的预定区域上的方法和装置公开(公告)号：US06802313B2
公开(公告)日：2004-10-12
申请号：US10047183
申请日：2001-10-23
IPC分类号： A61M1500
CPC分类号： A61K9/0075 , A61J3/00 , A61K9/0073 , A61M15/0045 , A61M15/0048 , A61M15/02 , A61M15/025 , B05B5/025 , B05B5/047 , G03G15/04045 , G03G15/221 , G03G15/323
摘要： Apparatus and a concomitant method for electrostatically depositing select doses of medicament powder at select locations on a substrate. Specifically, the apparatus contains a charged particle emitter for generating charged particles that charge a predefined region of a substrate and a charge accumulation control circuit for computing the amount of charge accumulated upon the substrate and deactivating the emitter when a selected quantity of charge has accumulated. Additionally, a triboelectric charging apparatus charges the medicament powder and forms a charged medicament cloud proximate the charged region of the substrate. The medicament particles within the medicament cloud electrostatically adhere to the charged region. The quantity of charge accumulated on the substrate at the predefined region and the charge-to-mass ratio of the medicament powder in the cloud control the amount (dose) of medicament deposited and retained by the substrate. Consequently, this apparatus accurately controls both medicament dosage and deposition location. Furthermore, since the substrate can be of any dielectric material that retains an electrostatic charge, the apparatus can be used to deposit medicament on substrates that are presently used in oral medicament consumption, e.g., substrates that are used to fabricate suppositories, inhalants, tablets, capsules and the like.
摘要翻译： 用于在基底上的选定位置静电沉积选择剂量的药物粉末的装置和伴随方法。 具体地，该装置包含用于产生对基板的预定区域充电的带电粒子的带电粒子发射器和用于计算在基板上累积的电荷量并且在已选择的电荷积累时停用发射极的电荷累积控制电路。 此外，摩擦带电装置对药物粉末进行充电，并在基底的带电区域附近形成带电药物云。 药物云内的药物颗粒静电附着到带电区域。 在预定区域上积累在基底上的电荷量和云中的药物粉末的电荷与质量比控制由基底沉积和保留的药物的量（剂量）。 因此，该装置精确地控制药物剂量和沉积位置。 此外，由于衬底可以是保持静电电荷的任何电介质材料，所以该装置可用于在目前用于口服药物消耗的基底上沉积药物，例如用于制造栓剂，吸入剂，片剂， 胶囊等。
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公开(公告)号：US6007630A
公开(公告)日：1999-12-28
申请号：US659501
申请日：1996-06-06
IPC分类号： A61J3/02 , A61J3/00 , A61K9/00 , A61M11/00 , A61M15/00 , A61M15/02 , B05B5/00 , B05B5/025 , B05B5/03 , B05B5/047 , B05B5/08 , G03G15/22 , G03G15/32
CPC分类号： A61K9/0075 , A61J3/00 , A61K9/0073 , A61M15/0045 , A61M15/0048 , A61M15/025 , B05B5/025 , B05B5/047 , G03G15/04045 , G03G15/221 , G03G15/323 , A61M15/02
摘要： Apparatus and a concomitant method for electrostatically depositing select doses of medicament powder at select locations on a substrate. Specifically, the apparatus contains a charged particle emitter for generating charged particles that charge a predefined region of a substrate and a charge accumulation control circuit for computing the amount of charge accumulated upon the substrate and deactivating the emitter when a selected quantity of charge has accumulated. Additionally, a triboelectric charging apparatus charges the medicament powder and forms a charged medicament cloud proximate the charged region of the substrate. The medicament particles within the medicament cloud electrostatically adhere to the charged region. The quantity of charge accumulated on the substrate at the predefined region and the charge-to-mass ratio of the medicament powder in the cloud control the amount (dose) of medicament deposited and retained by the substrate. Consequently, this apparatus accurately controls both medicament dosage and deposition location. Furthermore, since the substrate can be of any dielectric material that retains an electrostatic charge, the apparatus can be used to deposit medicament on substrates that are presently used in oral medicament consumption, e.g., substrates that are used to fabricate suppositories, inhalants, tablets, capsules and the like.
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5.发明授权Apparatus for electrostatically depositing a medicament powder upon predefined regions of a substrate 失效用于将药物粉末静电沉积在基底的预定区域上的装置
公开(公告)号：US5714007A
公开(公告)日：1998-02-03
申请号：US471889
申请日：1995-06-06
IPC分类号： A61J3/02 , A61J3/00 , A61K9/00 , A61M11/00 , A61M15/00 , A61M15/02 , B05B5/00 , B05B5/025 , B05B5/03 , B05B5/047 , B05B5/08 , G03G15/22 , G03G15/32 , B65B5/015
CPC分类号： A61K9/0075 , A61J3/00 , A61K9/0073 , A61M15/0045 , A61M15/0048 , A61M15/025 , B05B5/025 , B05B5/047 , G03G15/04045 , G03G15/221 , G03G15/323 , A61M15/02
摘要： Apparatus and a concomitant method for electrostatically depositing select doses of medicament powder at select locations on a substrate. Specifically, the apparatus contains charged particle emitter for generating charged particles that charge a predefined region of a substrate and a charge accumulation control circuit for computing the amount of charge accumulated upon the substrate and deactivating the emitter when a selected quantity of charge has accumulated. Additionally, a triboelectric charging apparatus charges the medicament powder and forms a charged medicament cloud proximate the charged region of the substrate. The medicament particles within the medicament cloud electrostatically adhere to the charged region. The quantity of charge accumulated on the substrate at the predefined region and the charge-to-mass ratio of the medicament powder in the cloud control the amount (dose) of medicament deposited and retained by the substrate. Consequently, this apparatus accurately controls both medicament dosage and deposition location. Furthermore, since the substrate can be of any dielectric material that retains an electrostatic charge, the apparatus can be used to deposit medicament on substrates that are presently used in oral medicament consumption, e.g., substrates that are used to fabricate suppositories, inhalants, tablets, capsules and the like.
摘要翻译： 用于在基底上的选定位置静电沉积选择剂量的药物粉末的装置和伴随方法。 具体地，该装置包含用于产生对基板的预定区域充电的带电粒子的带电粒子发射器和用于计算积累在基板上的电荷量并在所选择的电荷积累时停用发射极的电荷累积控制电路。 此外，摩擦带电装置对药物粉末进行充电，并在基底的带电区域附近形成带电药物云。 药物云内的药物颗粒静电附着到带电区域。 在预定区域上积累在基底上的电荷量和云中的药物粉末的电荷与质量比控制由基底沉积和保留的药物的量（剂量）。 因此，该装置精确地控制药物剂量和沉积位置。 此外，由于衬底可以是保持静电电荷的任何电介质材料，所以该装置可用于在目前用于口服药物消耗的基底上沉积药物，例如用于制造栓剂，吸入剂，片剂， 胶囊等。
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