公开(公告)号：US06802313B2

公开(公告)日：2004-10-12

申请号：US10047183

申请日：2001-10-23

Applicant: Timothy Allen Pletcher ,  Pabitra Datta ,  Christopher Just Poux ,  Randall Eugene McCoy

Inventor： Timothy Allen Pletcher ,  Pabitra Datta ,  Christopher Just Poux ,  Randall Eugene McCoy

IPC: A61M1500

CPC classification number: A61K9/0075 ,  A61J3/00 ,  A61K9/0073 ,  A61M15/0045 ,  A61M15/0048 ,  A61M15/02 ,  A61M15/025 ,  B05B5/025 ,  B05B5/047 ,  G03G15/04045 ,  G03G15/221 ,  G03G15/323

Abstract: Apparatus and a concomitant method for electrostatically depositing select doses of medicament powder at select locations on a substrate. Specifically, the apparatus contains a charged particle emitter for generating charged particles that charge a predefined region of a substrate and a charge accumulation control circuit for computing the amount of charge accumulated upon the substrate and deactivating the emitter when a selected quantity of charge has accumulated. Additionally, a triboelectric charging apparatus charges the medicament powder and forms a charged medicament cloud proximate the charged region of the substrate. The medicament particles within the medicament cloud electrostatically adhere to the charged region. The quantity of charge accumulated on the substrate at the predefined region and the charge-to-mass ratio of the medicament powder in the cloud control the amount (dose) of medicament deposited and retained by the substrate. Consequently, this apparatus accurately controls both medicament dosage and deposition location. Furthermore, since the substrate can be of any dielectric material that retains an electrostatic charge, the apparatus can be used to deposit medicament on substrates that are presently used in oral medicament consumption, e.g., substrates that are used to fabricate suppositories, inhalants, tablets, capsules and the like.

Abstract translation: 用于在基底上的选定位置静电沉积选择剂量的药物粉末的装置和伴随方法。 具体地，该装置包含用于产生对基板的预定区域充电的带电粒子的带电粒子发射器和用于计算在基板上累积的电荷量并且在已选择的电荷积累时停用发射极的电荷累积控制电路。 此外，摩擦带电装置对药物粉末进行充电，并在基底的带电区域附近形成带电药物云。 药物云内的药物颗粒静电附着到带电区域。 在预定区域上积累在基底上的电荷量和云中的药物粉末的电荷与质量比控制由基底沉积和保留的药物的量（剂量）。 因此，该装置精确地控制药物剂量和沉积位置。 此外，由于衬底可以是保持静电电荷的任何电介质材料，所以该装置可用于在目前用于口服药物消耗的基底上沉积药物，例如用于制造栓剂，吸入剂，片剂， 胶囊等。

公开(公告)号：US06792942B1

公开(公告)日：2004-09-21

申请号：US10448381

申请日：2003-05-30

Applicant: Jung-Hua Ho ,  Chiu-Chan Ho

Inventor： Jung-Hua Ho ,  Chiu-Chan Ho

IPC: A61M1500

CPC classification number: A61F5/566

Abstract: A sleep silencer serves for eliminating snore by holding in a mouth. The sleep silencer comprises a hollow tube which includes a front tube and a rear tube. One end of the front tube has an opening. A periphery of one distal end of the rear tube has a safety ring enclosing the periphery. A ball stop is installed at a center of the opening of the front tube. Two sides of the ball stop are formed with respective turbulent devices which are adhered to an inner wall of the front tube so as to buffer the air in the front tube.

Abstract translation: 睡眠消音器用于通过握住嘴巴来消除打鼾。 睡眠消音器包括一个包括前管和后管的中空管。 前管的一端具有开口。 后管的一个远端的周边具有围绕周边的安全环。 在前管的开口的中心安装有球止动件。 球挡块的两侧形成有各自的湍流装置，其粘附到前管的内壁，以便缓冲前管中的空气。

公开(公告)号：US06752148B1

公开(公告)日：2004-06-22

申请号：US09623937

申请日：2000-09-01

Applicant: Joseph T. McGinn ,  Suggy S. Chrai ,  Bogdan Brycki ,  Bawa Singh ,  Peter Coyle ,  Gary Santonastaso ,  Hoi Cheong Sun

Inventor： Joseph T. McGinn ,  Suggy S. Chrai ,  Bogdan Brycki ,  Bawa Singh ,  Peter Coyle ,  Gary Santonastaso ,  Hoi Cheong Sun

IPC: A61M1500

CPC classification number: A61M15/0045 ,  A61M15/0043 ,  A61M15/0048 ,  A61M15/0051 ,  A61M15/0055

Abstract: An inhaler disc cartridge comprises a carrier disc with radially outwardly extending resilient fingers, each with a medicament powder dosage. A sealing disc and an indexing ring are bonded to the disc. A cam sequentially and manually deflects a selected finger causing it to snap against an anvil to release the dosage by momentum energy transfer. In other embodiments, a cassette includes a carrier substrate reel of deposited powder dosages with a dosage sealing tape. The substrate comprises a belt with a plurality of transversely extending triangular fingers, each finger tip with a dosage thereon. Each finger is snapped in sequence against an anvil while a clamp secures the belt as the fingers are deflected. The spring fingers are corrugated in one embodiment cooperating with an anvil having channels and a device for inducing agglomeration breakup air streams through the channels. Other embodiments are for impact deflection of a dosage carrying substrate in a cartridge or cassette against an anvil to release the dosages.

Abstract translation: 一个吸入式盘盒包括一个具有径向向外延伸的弹性指状物的承载盘，每个都带有药物粉末剂量。 密封盘和分度环结合到盘上。 凸轮顺序地并且手动地偏转所选择的手指，使其与砧座卡扣以通过动量能量传递释放剂量。 在其他实施例中，盒包括具有剂量密封带的沉积的粉末剂量的载体衬底卷轴。 衬底包括具有多个横向延伸的三角形指状物的带，每个指尖具有其上的剂量。 每个手指按照砧座顺序扣合，同时当手指偏转时，夹具固定皮带。 在一个实施例中，弹簧指状物是波纹状的，与具有通道的砧座配合，以及用于通过通道引起团聚分解空气流的装置。 其他实施方案是用于将剂量携带衬底在药筒或药盒中抵抗砧座的冲击挠曲以释放剂量。

公开(公告)号：US06745765B2

公开(公告)日：2004-06-08

申请号：US10071998

申请日：2002-02-07

Applicant: Götz Kullik ,  Jochim Koch

Inventor： Götz Kullik ,  Jochim Koch

IPC: A61M1500

CPC classification number: A61M16/18 ,  A61M16/109 ,  A61M16/147 ,  A61M2205/073

Abstract: A reusable anesthetic container (1) has an anesthetic reserve space (2), which is provided with at least one movable wall element (3). The wall element (3) can be caused to follow the liquid anesthetic volume. In one embodiment, the movable wall element (3) is designed as a piston, which is caused to follow the anesthetic volume via a toothed piston rod (9). An elastomer ring is preferably provided on the storage container as a detent pawl for the piston rod (9). The anesthetic container (1) has a first metering element (5), which is actuated inductively by means of a complementary second metering element (6) cooperating with another metering element on the anesthesia apparatus (7) for metering the anesthetic.

Abstract translation: 可重复使用的麻醉容器（1）具有设置有至少一个可动壁元件（3）的麻醉储备空间（2）。 可以使壁元件（3）跟随液体麻醉体积。 在一个实施例中，可移动壁元件（3）被设计为活塞，其通过齿形活塞杆（9）而跟随麻醉体积。 弹性体环优选设置在储存容器上，作为用于活塞杆（9）的止动爪。 麻醉容器（1）具有第一计量元件（5），其通过与麻醉装置（7）上的另一计量元件配合的互补的第二计量元件（6）感应地致动，用于计量麻醉剂。

公开(公告)号：US06745763B2

公开(公告)日：2004-06-08

申请号：US09250272

申请日：1999-02-16

Applicant: Garth T. Webb

Inventor： Garth T. Webb

IPC: A61M1500

CPC classification number: B05B11/007 ,  A61M11/06 ,  B05B7/08 ,  B05B11/00412 ,  B05B11/0072 ,  B05B11/0078 ,  C12N2799/027 ,  Y10T137/7879 ,  Y10T137/788 ,  Y10T137/7886 ,  Y10T137/7895

Abstract: In existing vaporizers the medication passes through unsterilized passages which preclude heir use to administer sterile medications. The present invention therefore provides a device for dispensing a vaporized spray of sterile medicated liquid. It uses a combination atomizing and pressure release valve in which there is a flexible membrane with an aperture, and a plug extending upwardly through the aperture and having a surface against which the membrane is biassed in the closed position, the membrane lifting off the surface of the plug in the open position to thereby open the aperture.

Abstract translation: 在现有的蒸发器中，药物通过未灭菌的通道，排除继续使用来施用无菌药物。 因此，本发明提供了一种用于分配无菌药液的汽化喷雾的装置。 它使用组合雾化和压力释放阀，其中存在具有孔的柔性膜，以及向上延伸穿过孔的插塞，并且具有膜，所述表面在封闭位置被膜偏压，膜从表面上脱落 插头处于打开位置，从而打开光圈。

公开(公告)号：US06715485B1

公开(公告)日：2004-04-06

申请号：US09700532

申请日：2000-11-15

Applicant: Per Gisle Djupesland

Inventor： Per Gisle Djupesland

IPC: A61M1500

CPC classification number: A61M3/0233 ,  A61M3/0279 ,  A61M15/0018 ,  A61M15/002 ,  A61M15/0021 ,  A61M15/0028 ,  A61M15/0045 ,  A61M15/0065 ,  A61M15/009 ,  A61M15/0091 ,  A61M15/0098 ,  A61M15/08 ,  A61M16/0866 ,  A61M16/1055 ,  A61M16/1065 ,  A61M2202/0468 ,  A61M2202/064 ,  A61M2205/43 ,  A61M2205/59 ,  A61M2206/10 ,  A61M2206/14 ,  A61M2210/0618 ,  A61M2210/0625

Abstract: A delivery device (20, 22) for and a method of delivering a substance to the nasal airway (1) of a subject, in particular the posterior region of the nasal airway, the delivery device comprising: a closure unit for causing the closure of the oropharyngeal velum of the subject; and a delivery unit for delivering a gas flow entraining a substance to one of the nostrils of the subject at such a driving pressure as to flow around the posterior margin of the nasal septum and out of the other nostril of the subject, wherein the delivery unit comprises a nosepiece (30, 40, 58, 82, 102, 132) which includes an outlet through which the gas flow is in use delivered to the one nostril and a sealing member for sealing the one nostril to the outlet such as in use to prevent the escape of the gas flow through the one nostril.

Abstract translation: 一种用于将物质递送到受试者的鼻气道（1）的输送装置（20,22），特别是鼻气道的后部区域，所述输送装置包括：封闭单元， 主题的口咽舌头; 以及输送单元，用于以这样的驱动压力将夹带物质的气体流入到鼻隔膜的后缘周围并流过受试者的其他鼻孔，其中输送单元 包括一个鼻梁（30,40,58,82,102,132），其包括一个出口，气体流通过该出口被输送到一个鼻孔;以及密封构件，用于将一个鼻孔密封到出口，例如在使用中 防止气流通过一个鼻孔。

公开(公告)号：US06691702B2

公开(公告)日：2004-02-17

申请号：US10134868

申请日：2002-04-29

Applicant: William Scot Appel ,  David Phillip Winter ,  Brian Kenneth Sward ,  Masato Sugano ,  Edmund Salter ,  James A. Bixby

Inventor： William Scot Appel ,  David Phillip Winter ,  Brian Kenneth Sward ,  Masato Sugano ,  Edmund Salter ,  James A. Bixby

IPC: A61M1500

CPC classification number: B01D63/00 ,  A61M16/024 ,  A61M16/0677 ,  A61M16/10 ,  A61M16/101 ,  A61M16/107 ,  A61M16/1075 ,  A61M2016/1025 ,  A61M2202/0208 ,  A61M2202/03 ,  A61M2205/332 ,  A61M2205/3553 ,  A61M2205/3569 ,  A61M2205/8212 ,  A61M2205/8237 ,  A61M2230/04 ,  A61M2230/06 ,  A61M2230/205 ,  A61M2230/30 ,  A61M2230/40 ,  A61M2230/42 ,  A61M2230/50 ,  A61M2230/63 ,  A62B19/00 ,  B01D53/0446 ,  B01D53/047 ,  B01D53/0473 ,  B01D53/0476 ,  B01D53/053 ,  B01D53/22 ,  B01D53/261 ,  B01D53/326 ,  B01D2253/104 ,  B01D2253/106 ,  B01D2253/108 ,  B01D2256/12 ,  B01D2257/102 ,  B01D2257/80 ,  B01D2259/40005 ,  B01D2259/40009 ,  B01D2259/40052 ,  B01D2259/40081 ,  B01D2259/402 ,  B01D2259/4061 ,  B01D2259/4065 ,  B01D2259/4533 ,  B01D2259/4541 ,  B01D2313/18 ,  F16K15/021 ,  A61M2202/0007

Abstract: A portable oxygen concentrator system adapted to be readily transported by a user includes a rechargeable energy source and a concentrator powered by the energy source. The concentrator converts ambient air into concentrated oxygen gas for the user and includes a plurality of adsorption beds and a rotary valve assembly. The rotary valve assembly is relatively rotatable with respect to the plurality of adsorption beds to provide valving action for selectively transferring fluids through the plurality of adsorption beds for converting ambient air into concentrated oxygen gas for the user. The ratio of adiabatic power to oxygen flow for the concentrator is in the range of 6.2 W/LPM to 23.0 W/LPM.

Abstract translation: 适于容易地由使用者运送的便携式氧气浓缩器系统包括可再生能量源和由能量源供电的浓缩器。 集中器将环境空气转换成用户的浓氧气，并且包括多个吸附床和旋转阀组件。 旋转阀组件相对于多个吸附床可相对旋转，以提供阀选择性作用，用于选择性地将流体传送通过多个吸附床，以将环境空气转换成用于使用者的浓氧气。 集中器的绝热功率与氧气流量的比例在6.2 W / LPM到23.0 W / LPM的范围内。

公开(公告)号：US06688305B1

公开(公告)日：2004-02-10

申请号：US10138943

申请日：2002-05-03

Applicant: Doreen L. Perry

Inventor： Doreen L. Perry

IPC: A61M1500

CPC classification number: A61M11/00 ,  A61M2205/59

Abstract: A therapeutic aid for providing therapeutic vapors to a child having cold symptoms. The therapeutic aid includes a body member having a perimeter wall. The perimeter wall defines an interior space. The perimeter wall of the body member has a slot positioned along a front portion of the body member whereby the slot is for permitting access to the interior space of the body member. A treatment member is insertable into the interior space of the body member. The treatment member is designed for emitting therapeutic vapors through the body member for easing the cold symptoms of the child when the body member is positioned in a proximity to the child.

Abstract translation: 用于向具有冷症状的儿童提供治疗性蒸汽的治疗辅助剂。 治疗助剂包括具有周壁的主体构件。 周边墙壁定义了一个内部空间。 主体构件的周壁具有沿主体构件的前部定位的狭槽，由此狭槽用于允许进入主体构件的内部空间。 处理构件可插入主体构件的内部空间中。 治疗部件设计成用于通过身体部件发射治疗性蒸气，以便当身体部件位于儿童附近时，缓解儿童的感冒症状。

公开(公告)号：US06679256B2

公开(公告)日：2004-01-20

申请号：US09731368

申请日：2000-12-06

Applicant: Frank W. Ingle ,  Steve Paboojian ,  Carlos Schuler ,  Andrew Clark

Inventor： Frank W. Ingle ,  Steve Paboojian ,  Carlos Schuler ,  Andrew Clark

IPC: A61M1500

CPC classification number: B05B11/062 ,  A61M11/001 ,  A61M15/002 ,  A61M15/0028 ,  A61M15/0036 ,  A61M15/0041 ,  A61M2202/064 ,  A61M2205/073 ,  B05B7/1413 ,  B65D75/366 ,  B65D2575/362

Abstract: A method for aerosolizing a powder utilizes a receptacle having a cavity containing a powder. An access end of an extraction tube is inserted into the cavity, and an inlet opening is formed in the receptacle. A pressurized gas is flowed through the inlet opening, through the cavity and through the extraction tube to move the powder in the cavity into the extraction tube where the powder is entrained in the gas to form an aerosol.

Abstract translation: 用于雾化粉末的方法利用具有包含粉末的空腔的容器。 抽吸管的入口端插入空腔中，并且在容器中形成入口。 加压气体通过入口开口流过空腔并通过抽出管，将空腔中的粉末移动到提取管中，将粉末夹带在气体中形成气溶胶。

公开(公告)号：US06655381B2

公开(公告)日：2003-12-02

申请号：US09888277

申请日：2001-06-23

Applicant: Laurence Keane ,  David O'Leary

Inventor： Laurence Keane ,  David O'Leary

IPC: A61M1500

CPC classification number: G06M1/272 ,  A61M1/0001 ,  A61M15/0008 ,  A61M15/0045 ,  A61M15/0048 ,  A61M15/0068 ,  A61M15/0086 ,  A61M15/0091 ,  A61M2202/064 ,  A61M2206/16 ,  G06M1/248

Abstract: A pre-metered dose assembly for consistently supplying precise doses of medicament is provided for a breath-actuated dry powder inhaler. The assembly includes a cap defining a dry powder delivery passageway for providing air to a dry powder supply port of a swirl chamber of a breath-actuated dry powder inhaler, and a magazine including a plurality of reservoirs for holding pre-metered doses of dry powder. One of the magazine and the cap is movable with respect to the other of the magazine and the cap for sequentially positioning the reservoirs within the delivery passageway of the cap. A breath-induced low pressure at an outlet port of the swirl chamber of the inhaler causes an air flow through the dry powder delivery passageway of the assembly and into the dry powder supply port of the swirl chamber that entrains dry powder from the reservoir positioned in the passageway for inhalation by a patient using the inhaler. The present disclosure also provides a breath-actuated dry powder inhaler including the pre-metered dose assembly in combination with a de-agglomerator for breaking up aggregates and micronizing particles of dry powder prior to inhalation of the powder by a patient.