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    BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES
    5.
    发明申请
    BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES 审中-公开
    双功能复合物和制备和使用这种复合物的方法

    公开(公告)号：US20130281324A1

    公开(公告)日：2013-10-24

    申请号：US13641588

    申请日：2011-04-16

    申请人： Alex Haahr Gouliaev ,  Thomas Franch ,  Michael Anders Godskesen ,  Kim Birkebæk Jensen

    发明人： Alex Haahr Gouliaev ,  Thomas Franch ,  Michael Anders Godskesen ,  Kim Birkebæk Jensen

    IPC分类号： C12N15/10

    CPC分类号： C12N15/1065 ,  C12N15/1068

    摘要： The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.

    摘要翻译： 本发明涉及一种双官能复合物的合成方法，其包括分子部分和识别分子部分的识别寡核苷酸部分。 当包含任选保护的标签或寡核苷酸标识符的新生双功能复合物与固体支持物连接时，根据本发明的合成方法的一部分优选在一种或多种有机溶剂中进行，另一部分合成方法为 优选在适合于向溶液中的新生双功能复合物酶促添加寡核苷酸标签的条件下进行。

    Quasirandom Structure and Function Guided Synthesis Methods
    6.
    发明申请
    Quasirandom Structure and Function Guided Synthesis Methods 有权
    Quasirandom结构与功能引导合成方法

    公开(公告)号：US20080193983A1

    公开(公告)日：2008-08-14

    申请号：US10539288

    申请日：2003-12-19

    申请人： Alex Haahr Gouliaev ,  Anette Holtmann ,  Henrik Pedersen ,  Thomas Franch

    发明人： Alex Haahr Gouliaev ,  Anette Holtmann ,  Henrik Pedersen ,  Thomas Franch

    IPC分类号： C12P19/34 ,  C07H21/04 ,  C07K5/08 ,  G01N33/50

    CPC分类号： C40B30/04 ,  C12N15/1068 ,  C40B20/04 ,  C40B40/06 ,  C40B50/04 ,  C40B50/08 ,  Y10T436/145555

    摘要： The present invention is directed to the synthesis of molecules guided b connector polynucleotides (CPNs capable of hybridizing to complementary connector polynucleotides (CCPNs) harbouring at least one functional entity comprising at least one reactive group. At least one of said CCPNs capable of hybridize to at least two CPNs. Each CPN will “call” for one or more CCPNs capable of hybridization to the CPN. Following the formation of a supramolecular hybridization complex comprising a plurality of CPNs and a plurality of CCPNs, the reaction of functional entity reactive groups result I the formation of a molecule comprising covalently linked functional entities. The formation of the molecule involves the transfer of functional entities from one or more “donor CCPNs” to at least on “acceptor CCPN” with which the transferred functional entities were not associated prior to the transfer.

    摘要翻译： 本发明涉及分子引导的b连接体多核苷酸（能够与包含至少一个包含至少一个反应性基团的至少一个功能实体的互补连接子多核苷酸（CCPN）杂交）的分子的合成，所述至少一种能够与 至少两个CPN，每个CPN将“呼叫”一个或多个能够与CPN杂交的CCPN，形成包含多个CPN和多个CCPN的超分子杂交复合物后，功能性实体反应性基团的反应导致I 分子的形成包括共价连接的功能实体。分子的形成涉及将功能性实体从一个或多个“供体CCPN”转移至至少在“受体CCPN”之间，转移的功能实体在其之前不相关联 转让。

    Quasirandom structure and function guided synthesis methods
    8.
    发明授权
    Quasirandom structure and function guided synthesis methods 有权
    曲斯兰结构和功能指导合成方法

    公开(公告)号：US09121110B2

    公开(公告)日：2015-09-01

    申请号：US10539288

    申请日：2003-12-19

    申请人： Alex Haahr Gouliaev ,  Anette Holtmann ,  Henrik Pedersen ,  Thomas Franch

    发明人： Alex Haahr Gouliaev ,  Anette Holtmann ,  Henrik Pedersen ,  Thomas Franch

    IPC分类号： C40B50/00 ,  C40B20/04 ,  C40B30/00 ,  C40B50/10 ,  C12Q1/68 ,  C07H21/02 ,  C40B30/04 ,  C12N15/10 ,  C40B40/06 ,  C40B50/08 ,  C40B50/04

    CPC分类号： C40B30/04 ,  C12N15/1068 ,  C40B20/04 ,  C40B40/06 ,  C40B50/04 ,  C40B50/08 ,  Y10T436/145555

    摘要： The present invention is directed to the synthesis of molecules guided by connector polynucleotides (CPNs) capable of hybridizing to complementary connector polynucleotides (CCPNs) harboring at least one functional entity comprising at least one reactive group. At least one of the CCPNs is capable of hybridizing to at least two CPNs. Each CPN will “call” for one or more CCPNs capable of hybridization to the CPN. Following the formation of a supramolecular hybridization complex comprising a plurality of CPNs and a plurality of CCPNs, the reaction of reactive groups results in the formation of a molecule comprising covalently linked functional entities. The formation of the molecule involves the transfer of functional entities from one or more “donor CCPNs” to at least one “acceptor CCPN” with which the transferred functional entities were not associated prior to the transfer.

    摘要翻译： 本发明涉及由能够与包含至少一个反应性基团的至少一个功能实体的互补连接多核苷酸（CCPN）杂交的连接体多核苷酸（CPN）引导的分子的合成。 至少有一个CCPN能够与至少两个CPN杂交。 每个CPN将“呼叫”一个或多个能够与CPN杂交的CCPN。 在形成包含多个CPN和多个CCPN的超分子杂交复合物之后，反应性基团的反应导致包含共价连接的功能性实体的分子的形成。 分子的形成涉及将功能性实体从一个或多个“供体CCPN”转移至至少一个转移的功能实体在转移之前与之不相关的“受体CCPN”。