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    PERCUTANEOUSLY DELIVERABLE HEART VALVE INCLUDING FOLDED MEMBRANE CUSPS WITH INTEGRAL LEAFLETS
    1.
    发明申请
    PERCUTANEOUSLY DELIVERABLE HEART VALVE INCLUDING FOLDED MEMBRANE CUSPS WITH INTEGRAL LEAFLETS 有权

    公开(公告)号：US20210228347A1

    公开(公告)日：2021-07-29

    申请号：US17226438

    申请日：2021-04-09

    申请人： Colibri Heart Valve LLC

    发明人： R. David Fish ,  Eduardo Induni ,  David Paniagua

    IPC分类号： A61F2/24

    摘要： A transcatheter, percutaneously implantable, prosthetic heart valve is provided that comprises a lattice frame and two or more integrated cusp and leaflet folded structures attached to the lattice frame. The two or more integrated cusp and leaflet folded structures each comprise a flat sheet of biocompatible membrane that is folded to include a substantially conical shape according to a flat folding pattern. The substantially conical shape is further formed by joining apposing sides of the substantially conical shape along a seam. The two or more integrated cusp and leaflet folded structures are each attached along their respective seams to the lattice frame in a direction substantially parallel to an axis of the lattice frame. Embodiments of valves described herein have application within the entire vascular system.

    PERCUTANEOUSLY IMPLANTABLE REPLACEMENT HEART VALVE DEVICE AND METHOD OF MAKING SAME
    3.
    发明申请
    PERCUTANEOUSLY IMPLANTABLE REPLACEMENT HEART VALVE DEVICE AND METHOD OF MAKING SAME 审中-公开
    PERCUTANEOUSLY IMPLANTABLE REPLATEMENT HEART VALVE DEVICE AND METHOD OF MAKING SAME

    公开(公告)号：US20150351902A1

    公开(公告)日：2015-12-10

    申请号：US14829349

    申请日：2015-08-18

    申请人： COLIBRI HEART VALVE LLC

    发明人： David PANIAGUA ,  R. David FISH

    IPC分类号： A61F2/24 ,  A61L31/02 ,  A61L27/36

    CPC分类号： A61F2/2415 ,  A61F2240/002 ,  A61L27/3625 ,  A61L27/3687 ,  A61L31/022 ,  A61L2430/20

    摘要： A method of making a replacement heart valve device whereby a fragment of biocompatible tissue material is treated and soaked in one or more alcohol solutions and a solution of glutaraldehyde. The dried biocompatible tissue material is folded and rehydrated in such a way that forms a two- or three-leaflet/cusp valve without affixing of separate cusps or leaflets or cutting slits into the biocompatible tissue material to form the cusps or leaflets. After the biocompatible tissue material is folded, it is affixed at one or more points on the outer surface to the inner cavity or a stent.

    摘要翻译： 一种制备置换心脏瓣膜装置的方法，其中生物相容性组织材料的片段被处理并浸泡在一种或多种醇溶液和戊二醛溶液中。 干燥的生物相容性组织材料被折叠并再水化，以形成两个或三个小叶/尖瓣瓣膜，而不必将独立的尖头或小叶或切割狭缝固定到生物相容性组织材料中以形成尖头或小叶。 在生物相容的组织材料折叠之后，将其固定在外表面上的一个或多个点到内腔或支架。

    PERCUTANEOUSLY DELIVERABLE HEART VALVE AND METHODS ASSOCIATED THEREWITH
    6.
    发明申请
    PERCUTANEOUSLY DELIVERABLE HEART VALVE AND METHODS ASSOCIATED THEREWITH 审中-公开
    非常可交付的心脏瓣膜及其相关方法

    公开(公告)号：US20130123914A1

    公开(公告)日：2013-05-16

    申请号：US13723541

    申请日：2012-12-21

    申请人： COLIBRI HEART VALVE LLC

    发明人： R. David FISH ,  David PANIAGUA

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2427 ,  A61F2/0095 ,  A61F2/2412 ,  A61F2/2415 ,  A61F2/2418 ,  A61F2/2433 ,  A61F2220/0075 ,  Y10T29/49908 ,  Y10T156/10

    摘要： A prosthetic heart valve implantable by catheter without surgery includes a substantially “dry” membrane or tissue material. In at least one embodiment, the tissue is folded in a dry state to form a tissue leaflet assembly that is then attached to a frame to form an implantable prosthetic heart valve. Alternatively, one or more tissue leaflets are operatively associated with a frame to form an implantable prosthetic heart valve. The implantable prosthetic heart valve is subsequently pre-mounted on an integrated catheter delivery system. The catheter delivery system that includes the implantable prosthetic heart valve is then packaged and transported while the tissue remains dry. The implantable prosthetic heart valve, while remaining substantially dry, can then be implanted into the receiving patient.

    摘要翻译： 通过没有手术的导管植入的假体心脏瓣膜包括基本上“干”的膜或组织材料。 在至少一个实施例中，组织以干燥状态折叠以形成组织小叶组件，然后将组织小叶组件附接到框架以形成可植入的假体心脏瓣膜。 或者，一个或多个组织小叶与框架可操作地相关联以形成可植入假体心脏瓣膜。 随后将可植入式假体心脏瓣膜预先安装在集成的导管递送系统上。 包括可植入假体心脏瓣膜的导管递送系统然后在组织保持干燥时被包装和运输。 可植入假体心脏瓣膜虽然保持基本上干燥，然后可以植入接受患者。

    PERCUTANEOUSLY DELIVERABLE HEART VALVE INCLUDING FOLDED MEMBRANE CUSPS WITH INTEGRAL LEAFLETS
    7.
    发明申请
    PERCUTANEOUSLY DELIVERABLE HEART VALVE INCLUDING FOLDED MEMBRANE CUSPS WITH INTEGRAL LEAFLETS 审中-公开

    公开(公告)号：US20180185143A1

    公开(公告)日：2018-07-05

    申请号：US15680350

    申请日：2017-08-18

    申请人： Colibri Heart Valve LLC

    发明人： R. David FISH ,  Eduardo INDUNI ,  David PANIAGUA

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2415 ,  A61F2/2418 ,  A61F2220/0075 ,  A61F2230/0054

    摘要： A transcatheter, percutaneously implantable, prosthetic heart valve is provided that comprises a lattice frame and two or more integrated cusp and leaflet folded structures attached to the lattice frame. The two or more integrated cusp and leaflet folded structures each comprise a flat sheet of biocompatible membrane that is folded to include a substantially conical shape according to a flat folding pattern. The substantially conical shape is further formed by joining apposing sides of the substantially conical shape along a seam. The two or more integrated cusp and leaflet folded structures are each attached along their respective seams to the lattice frame in a direction substantially parallel to an axis of the lattice frame. Embodiments of valves described herein have application within the entire vascular system.