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    Process for separation of syn and anti oxime isomers of cephalosporin-compounds
    3.
    发明授权
    Process for separation of syn and anti oxime isomers of cephalosporin-compounds 失效
    分离头孢菌素化合物的顺式和反式肟异构体的方法

    公开(公告)号：US4717768A

    公开(公告)日：1988-01-05

    申请号：US648382

    申请日：1984-09-07

    Applicant: Colin Robinson ,  David T. Eastlick ,  Audrey J. Bownass

    Inventor： Colin Robinson ,  David T. Eastlick ,  Audrey J. Bownass

    IPC: C07D277/30 ,  C07D307/54 ,  C07D501/04 ,  C07D501/12 ,  C07D501/14 ,  C07D501/20 ,  C07D501/34 ,  C07D501/46 ,  A61K31/545

    CPC classification number: C07D307/54

    Abstract: A process for the separation of a mixture of syn and anti oxime isomers one from the other which comprises adsorbing said mixed oxime isomers onto a non-functional macroreticular adsorption resin, and eluting said resin to yield at least one eluate fraction containing one of said isomers while being substantially free of the other of said isomers.The application of this process to the separation of syn and anti isomers of cephalosporin compounds possessing an oxime grouping in a side-chain in the 7.beta.-position, and of acids corresponding to this 7.beta.-side chain, is described.

    Abstract translation: 一种将Syn和反肟异构体混合物分离的方法，其包括将所述混合肟异构体吸附到非功能性大网络吸附树脂上，并洗脱所述树脂以产生至少一种含有所述异构体之一的洗脱液组分 同时基本上不含其它所述异构体。 描述了该方法在7β-位的侧链中具有肟基的头孢菌素化合物和对应于该7β-侧链的酸的顺式和反异构体的分离的应用。

    Extraction of N-blocked amino acids from aqueous media
    5.
    发明授权
    Extraction of N-blocked amino acids from aqueous media 失效
    从含水介质中提取N-封闭的氨基酸

    公开(公告)号：US4059573A

    公开(公告)日：1977-11-22

    申请号：US671935

    申请日：1976-03-30

    Applicant: Colin Robinson ,  Derek Walker

    Inventor： Colin Robinson ,  Derek Walker

    IPC: C07D499/00 ,  C07D499/18 ,  C07D501/12 ,  C07C103/52

    CPC classification number: C07D499/00

    Abstract: N-blocked amino acids, particularly derived from natural sources such as fermentation liquors, are extractively esterified from aqueous media by treatment of the aqueous solution with a diazoalkane, e.g. diphenyldiazomethane, in the presence of a water-immiscible organic solvent. Useful applications of the process include the extractive esterification of N-blocked derivatives of cephalosporin C and desacetyl cephalosporin C from fermentation broths.

    Abstract translation: 特别是衍生自天然来源例如发酵液的N-封闭的氨基酸通过用重氮烷（例如水溶液）处理水溶液从水性介质中萃取酯化。 二苯基重氮甲烷，在与水不混溶的有机溶剂的存在下。 该方法的有用应用包括从发酵液中提取酯化头孢菌素C和去乙酰基头孢菌素C的N-封闭衍生物。

    "> Process for the separation of a mixture of
    7.
    发明授权
    Process for the separation of a mixture of "syn" and "anti" oxime isomers 失效
    分离“顺式”和“抗”肟异构体混合物的方法

    公开(公告)号：US4876351A

    公开(公告)日：1989-10-24

    申请号：US114841

    申请日：1987-10-30

    Applicant: Colin Robinson ,  David T. Eastlick ,  Audrey J. Bownass

    Inventor： Colin Robinson ,  David T. Eastlick ,  Audrey J. Bownass

    IPC: C07D277/30 ,  C07D307/54 ,  C07D501/04 ,  C07D501/12 ,  C07D501/14 ,  C07D501/20 ,  C07D501/34 ,  C07D501/46

    CPC classification number: C07D307/54

    Abstract: A process for the separation of a mixture of syn and anti oxime isomers one from the other which comprises adsorbing said mixed oxime isomers onto a non-functional macroreticular adsorption resin, and eluting said resin to yield at least one eluate fraction containing one of said isomers while being substantially free of the other of said isomers.The application of this process to the separation of syn and anti isomers of cephalosporin compounds possessing an oxime grouping in a side-chain in the 7.beta.-position, and of acids corresponding to this 7.beta.-side chain, is described.

    Abstract translation: 一种将Syn和反肟异构体混合物分离的方法，其包括将所述混合肟异构体吸附到非功能性大网络吸附树脂上，并洗脱所述树脂以产生至少一种含有所述异构体之一的洗脱液组分 同时基本上不含其它所述异构体。 描述了该方法在7β-位的侧链中具有肟基的头孢菌素化合物和对应于该7β-侧链的酸的顺式和反异构体的分离的应用。

    Ceftazidime dihydrochloride formic acid solvates
    9.
    发明授权
    Ceftazidime dihydrochloride formic acid solvates 失效
    头孢他啶二盐酸盐甲酸溶剂化物

    公开(公告)号：US4943632A

    公开(公告)日：1990-07-24

    申请号：US305541

    申请日：1989-02-03

    Applicant: Colin Robinson

    Inventor： Colin Robinson

    IPC: C07D501/00 ,  A61K31/545 ,  C07D501/46

    CPC classification number: A61K31/545

    Abstract: The invention relates to the crystalline formic acid solvate of (6R, 7R)-7-[(Z)-2-(2-Aminothiazol-4-y1)-2-(2-carboxyprop-2-oxyimino)acetamido]-3-(1-pyridiniummethyl)ceph-3-em-4-carboxylate dihydrochloride (ceftazidime dihydrochloride).The crystalline solvate is a useful intermediate in the preparation of forms of ceftazidime suitable for administration, e.g. the pentahydrate.

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