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公开(公告)号：US20210283301A1
公开(公告)日：2021-09-16
申请号：US17332833
申请日：2021-05-27
Applicant: Collagen Matrix, Inc.
Inventor： Lukas Pfister , Kurt Ruffieux
Abstract: A bone graft substitute which combines substantially the high mechanical stability of spherical porous granules without the limitation of reduced intergranular space, and a method for manufacturing the bone graft substitute. In an exemplary embodiment of the invention, the surface of the granules comprises indentations that increases the porosity within the implanted mass significantly and thus provides more space between the granules for tissue ingrowth. The indentations on the granules cause them to have an irregular shape and thus an increase in the intergranular space is achieved, while mechanical stability is maintained. An exemplary method according to the invention includes the steps of manufacturing the granules; mixing the granules with a porogen; pressing the porogen into the surface of at least a portion of the granules; and removing the porogen from the implant mass to form the indentations in the surface where the porogen was pressed into the granules.
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公开(公告)号：US20210236689A1
公开(公告)日：2021-08-05
申请号：US17234365
申请日：2021-04-19
Applicant: Collagen Matrix, Inc.
Inventor： Lukas PFISTER , Kurt RUFFIEUX
Abstract: A bone graft substitute which combines substantially the high mechanical stability of spherical porous granules without the limitation of reduced intergranular space. The granules have a high porosity whilst maintaining high stability, and can be pushed into a defect without risking significant breakage of the granules and, simultaneously, bone cells can grow into the space between the granules. In an exemplary embodiment of the invention, the surface of the granules comprises indentations, when viewed from the exterior of the granules. An indentation increases the porosity within the implanted mass significantly and thus provides more space between the granules for tissue ingrowth. Due to the indentations on the granules, the granules have an irregular shape and thus an increase in the intergranular space is achieved, while mechanical stability is maintained. A biocompatible polymer, such as a polypeptide, is disposed about at least some of the granules to form a coating thereon.
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公开(公告)号：US10286104B2
公开(公告)日：2019-05-14
申请号：US15450789
申请日：2017-03-06
Applicant: Collagen Matrix, Inc.
Inventor： Shu-Tung Li , Hui-Chen Chen , Debbie Yuen
Abstract: A carbonate apatite prepared from natural bone. The carbonate apatite has a protein content of 2000-8000 parts per million and a surface area of 15 to 70 m2/g. Also provided is a method for preparing the carbonate apatite from cancellous bone particles.
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公开(公告)号：US10279077B2
公开(公告)日：2019-05-07
申请号：US16101907
申请日：2018-08-13
Applicant: Collagen Matrix, Inc.
Inventor： Shu-Tung Li , Debbie Yuen
Abstract: A collagen-coated tissue based membrane that is smooth on both sides so as to inhibit cell and tissue adhesion. Also disclosed are methods for making a collagen-coated tissue-based membrane.
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公开(公告)号：US20250032667A1
公开(公告)日：2025-01-30
申请号：US18712869
申请日：2022-11-29
Applicant: Collagen Matrix, Inc.
Inventor： Hui-Chen Chen , Shruti Saxena , Daniel Ammon , Diana Legarda
Abstract: Bioactive ceramic particles (such as bioglass) that are customized with ions to enhance tissue healing. The ions may include one or more of Magnesium, Copper, Cobalt, Silver, Aluminum, Iron, Manganese, Zinc, Calcium, Lithium, Gallium, Strontium and/or other Group 5 based ions. Medical applications for use of the customized bioglass particles include wound (dermis) repair, orthopedics (bone), spine, tendon, ligaments, cartilage, neurologic and dental. Embodiments of the customized bioglass particles contain multiple layers, each layer having a different composition. In some embodiments, the ions in each layer work in conjunction with a biologic process. Also disclosed are methods for forming the customized bioglass particles.
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Patent Agency Ranking
公开(公告)号：US10945846B2
公开(公告)日：2021-03-16
申请号：US15241568
申请日：2016-08-19
Applicant: Collagen Matrix, Inc.
Inventor： Shu-Tung Li , Hui-Chen Chen , Debbie Yuen
Abstract: An implant for the repair of bone and cartilage that includes a cell conductive zone that contains biopolymeric fibers and an osteoconductive zone that contains biopolymeric fibers and calcium-containing mineral particles. The biopolymeric fibers from one zone overlap with the fibers in the other zone forming a stable physical and mechanical integration of the two zones, thus conferring in vivo stability to the implant.
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公开(公告)号：US20200038193A1
公开(公告)日：2020-02-06
申请号：US16597181
申请日：2019-10-09
Applicant: Collagen Matrix, Inc.
Inventor： Shu-Tung Li , Natsuyo S. Lee , Gregory J. Pomrink
Abstract: A method for producing a collagen meniscus implant by obtaining a freshly excised non-human meniscus, rinsing it in an aqueous solution, drying the rinsed meniscus, shaping it to approximate in dimension an average-sized human meniscus, extracting non-collagenous material from the shaped meniscus, cross-linking, and sterilizing it, yielding a collagen meniscus implant containing at least 90% by weight of type I collagen, less than 0.5% by weight of native glycosaminoglycan, and less than 600 ppm DNA. Also disclosed is a collagen meniscus implant prepared by the above method. Further provided is a biocompatible and bioresorbable porous implant for meniscus repair. The implant includes a three-dimensional network of collagen fibers oriented in a direction approximating the collagen fiber orientation of a human meniscus. The implant has a size and a contour substantially equivalent to a human meniscus, and has a chemical composition similar to the above-described collagen meniscus implant.
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公开(公告)号：US10537417B2
公开(公告)日：2020-01-21
申请号：US15204517
申请日：2016-07-07
Applicant: Collagen Matrix, Inc.
Inventor： Shu-Tung Li , Natsuyo Shishido Lee , Debbie Yuen
Abstract: A density gradient biopolymeric matrix implant is disclosed. The implant includes a first homogeneous matrix layer and a second homogeneous matrix layer having a density different from that of the first homogeneous matrix layer. Biopolymeric fibers at the surface of the first homogeneous matrix layer are physically in contact with and cross-linked to the biopolymeric fibers at the surface of the second homogeneous matrix layer. Also disclosed is a three-dimensional density gradient biopolymeric matrix implant that includes a first homogeneous matrix surrounding a second homogeneous matrix having a different density. Biopolymeric fibers at an inner surface of the first homogeneous matrix are physically in contact with and cross-linked to biopolymeric fibers at an outer surface of the second homogeneous matrix. Furthermore, methods for preparing the density gradient biopolymeric matrix implant and the three-dimensional density gradient biopolymeric matrix implant are provided.
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公开(公告)号：US20190054208A1
公开(公告)日：2019-02-21
申请号：US15680700
申请日：2017-08-18
Applicant: Collagen Matrix, Inc.
Inventor： Shu-Tung Li , Natsuyo Shishido Lee
Abstract: A method for producing a collagen meniscus implant by obtaining a freshly excised non-human meniscus, rinsing it in an aqueous solution, drying the rinsed meniscus, shaping it to approximate in dimension an average-sized human meniscus, extracting non-collagenous material from the shaped meniscus, and sterilizing it, yielding a collagen meniscus implant containing at least 90% by weight of type I collagen, less than 0.5% by weight of glycosaminoglycan, and less than 600 ppm DNA. Also disclosed is a collagen meniscus implant prepared by the above method. Further provided is a biocompatible and bioresorbable porous implant for meniscus repair. The implant includes a three-dimensional network of collagen fibers oriented in a direction approximating the collagen fiber orientation of a human meniscus. The implant has a size and a contour substantially equivalent to a human meniscus, and has a chemical composition similar to the above-described collagen meniscus implant.
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公开(公告)号：US11969349B2
公开(公告)日：2024-04-30
申请号：US17199920
申请日：2021-03-12
Applicant: Collagen Matrix, Inc.
Inventor： Shu-Tung Li , Hui-Chen Chen , Debbie Yuen
CPC classification number: A61F2/28 , A61F2/30756 , A61L27/12 , A61L27/24 , A61L27/3847 , A61L27/3852 , A61L27/54 , A61L27/58 , A61F2002/2839 , A61F2002/30016 , A61F2002/30062 , A61F2002/30293 , A61F2002/3092 , A61F2310/00371 , A61L2430/02 , A61L2430/06
Abstract: An implant for the repair of bone and cartilage that includes a cell conductive zone that contains biopolymeric fibers and an osteoconductive zone that contains biopolymeric fibers and calcium-containing mineral particles. The biopolymeric fibers from one zone overlap with the fibers in the other zone forming a stable physical and mechanical integration of the two zones, thus conferring in vivo stability to the implant.
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