公开(公告)号：US20240245515A1

公开(公告)日：2024-07-25

申请号：US18621297

申请日：2024-03-29

申请人： Collagen Matrix, Inc.

发明人： Shu-Tung Li ,  Hui-Chen Chen ,  Debbie Yuen

IPC分类号： A61F2/28 ,  A61F2/30 ,  A61L27/12 ,  A61L27/24 ,  A61L27/38 ,  A61L27/54 ,  A61L27/58

CPC分类号： A61F2/28 ,  A61F2/30756 ,  A61L27/12 ,  A61L27/24 ,  A61L27/3847 ,  A61L27/3852 ,  A61L27/54 ,  A61L27/58 ,  A61F2002/2839 ,  A61F2002/30016 ,  A61F2002/30062 ,  A61F2002/30293 ,  A61F2002/3092 ,  A61F2310/00371 ,  A61L2430/02 ,  A61L2430/06

摘要： An implant for the repair of bone and cartilage that includes a cell conductive zone that contains biopolymeric fibers and an osteoconductive zone that contains biopolymeric fibers and calcium-containing silicate based glass. The biopolymeric fibers from one zone overlap with the fibers in the other zone forming a stable physical and mechanical integration of the two zones, thus conferring in vivo stability to the implant.

公开(公告)号：US11918453B2

公开(公告)日：2024-03-05

申请号：US17199956

申请日：2021-03-12

申请人： ARTHREX, INC.

发明人： David Shepard ,  John Tokish ,  Brian Dorn

IPC分类号： A61F2/08 ,  A61L17/08 ,  A61L27/36 ,  A61L27/38 ,  A61L27/54 ,  A61L27/58

CPC分类号： A61F2/08 ,  A61L17/08 ,  A61L27/3604 ,  A61L27/365 ,  A61L27/3654 ,  A61L27/3658 ,  A61L27/3662 ,  A61L27/367 ,  A61L27/3834 ,  A61L27/3847 ,  A61L27/3852 ,  A61L27/3856 ,  A61L27/386 ,  A61L27/3873 ,  A61L27/3886 ,  A61L27/54 ,  A61L27/58 ,  A61L2430/10

摘要： The present disclosure describes methods of treating an injury in a subject using placental tissue streamers, engineered tissue placental tissue hybrids, suture placental tissue hybrids, placental tissue patch hybrids, and tissue hybrids, and the use of these compositions to repair, treat, or support an injury or degenerative process in a subject.

公开(公告)号：US11752002B2

公开(公告)日：2023-09-12

申请号：US16636706

申请日：2018-08-13

申请人： Griffith University ,  Queensland University of Technology ,  Gold Coast Hospital And Health Service

发明人： Cedryck Vaquette ,  Hei Man Hayman Lui ,  Saso Ivanovski ,  Randy Bindra

IPC分类号： A61F2/46 ,  A61F2/08 ,  A61F2/42 ,  B33Y80/00 ,  A61L27/22 ,  A61L27/24 ,  A61L27/38 ,  B33Y10/00 ,  A61F2/30

CPC分类号： A61F2/4261 ,  A61F2/08 ,  A61L27/222 ,  A61L27/225 ,  A61L27/227 ,  A61L27/24 ,  A61L27/386 ,  A61L27/3817 ,  A61L27/3821 ,  A61L27/3847 ,  A61L27/3886 ,  B33Y80/00 ,  A61F2002/30009 ,  A61F2002/30011 ,  A61F2002/30062 ,  A61F2002/30962 ,  A61F2002/30985 ,  A61F2002/4289 ,  A61F2002/4292 ,  B33Y10/00

摘要： The present invention relates to a three-dimensional multiphasic synthetic tissue scaffold comprising first, second and third compartments, wherein: each said compartment comprises distinct microstructural, and/or chemical, and/or mechanical properties, and is connected with at least one other compartment of the scaffold via a continuous interface; the tissue scaffold is porous; and the external morphology of the tissue scaffold mimics that of a mammalian joint or a component thereof. The invention further relates to a method for producing the three dimensional multiphasic synthetic tissue scaffold using a polymeric material, the method comprising using a three-dimensional (3D) bioprinter to print the tissue scaffold by continuously deposit the polymeric material onto a platform until the tissue scaffold is produced in its entirety.

公开(公告)号：US20230270554A1

公开(公告)日：2023-08-31

申请号：US18142238

申请日：2023-05-02

申请人： University of Connecticut

发明人： Thanh Duc Nguyen ,  Ritopa Das

IPC分类号： A61F2/28 ,  A61L27/58 ,  A61L27/34 ,  A61L27/18 ,  A61L27/54 ,  A61L27/38

CPC分类号： A61F2/28 ,  A61L27/58 ,  A61L27/34 ,  A61L27/18 ,  A61L27/54 ,  A61L27/3847 ,  A61L2430/02 ,  A61F2002/2864 ,  A61F2002/2821 ,  A61F2002/30062

摘要： A scaffold comprised of a plurality of PLLA layers, which may include stem cells, for regenerating bone or tissue. The PLLA layers are separated by a plurality of hydrogel layers. The PLLA layers comprise a nanofiber mesh having a piezoelectric constant to apply an electrical charge to the bone or tissue upon application of ultrasound energy.

公开(公告)号：US20230241292A1

公开(公告)日：2023-08-03

申请号：US18134274

申请日：2023-04-13

申请人： ForCyte Medical, LLC ,  The Cleveland Clinic Foundation

发明人： Robert Assell ,  Andrew Freeman ,  George Muschler

IPC分类号： A61L27/38 ,  A61B17/88 ,  A61L27/46

CPC分类号： A61L27/3847 ,  A61L27/3821 ,  A61B17/8833 ,  A61L27/46 ,  A61L2430/02

摘要： A bone void filler preparation system that includes a processing vessel, a processing cover, a bone void filler preparation container and tubing. The processing vessel has a recess formed therein. The processing vessel is adapted to receive bone marrow aspirate. The processing cover includes an outer wall, a central wall member and a connection port. The outer wall has an upper edge and a lower edge. The central wall member extends inwardly from the outer wall intermediate the upper and lower edges of the processing cover. The central wall member has an aperture formed therein. The central wall member has a downwardly directed portion that defines an air-retaining region. The air-retaining region is closer to the outer wall upper edge than the aperture. The connection port is operably connected to the aperture. The processing cover is movable in the processing cover recess. The bone void filler preparation container has an inlet portion and an outlet port. The bone void filler preparation container is adapted to receive a bone void filler matrix therein. The tubing fluidly connects the processing cover connection port and the bone void filler preparation container inlet port.

公开(公告)号：US20190231933A1

公开(公告)日：2019-08-01

申请号：US16264717

申请日：2019-02-01

申请人： Board of Supervisors of Louisiana State University and Agricultural and Mechanical College

发明人： Yufeng DONG

IPC分类号： A61L27/38 ,  A61L27/54 ,  A61L27/58 ,  A61L27/28 ,  A61L27/36 ,  A61L27/14 ,  A61L27/04

CPC分类号： A61L27/3834 ,  A61L27/04 ,  A61L27/14 ,  A61L27/28 ,  A61L27/365 ,  A61L27/3847 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/412 ,  A61L2420/02 ,  A61L2430/02

摘要： A tissue engineered periosteum for a patient comprising a sheet of stem cells. A method of repairing bone injury on a patient comprising implanting into the patient an engineered bone graph comprising a scaffold wrapped in a tissue engineered periosteum. A tissue engineered bone graph comprising a scaffold and a tissue engineered periosteum wrapped around an exterior of the scaffold.

公开(公告)号：US10010649B2

公开(公告)日：2018-07-03

申请号：US12598811

申请日：2008-05-02

申请人： Christer Busch

发明人： Christer Busch

IPC分类号： A61L27/20 ,  A61L27/38 ,  C12N5/077 ,  C12N5/0775

CPC分类号： A61L27/20 ,  A61L27/3821 ,  A61L27/3834 ,  A61L27/3847 ,  A61L27/3865 ,  A61L27/3895 ,  A61L2430/02 ,  C12N5/0654 ,  C12N5/0663 ,  C12N2533/78 ,  C08L1/08

摘要： A method of culturing human or mammalian mesenchymal stem cells (MSC) or osteoblastic cells to form corresponding cell aggregates evenly distributed in the culturing medium having a reduced content of cells with fibroblast morphology comprises contacting MSC or OC with a water-soluble cellulose derivative over a period of from 1 day to one or two weeks. Also disclosed are a corresponding aggregates, a culture medium and a pharmaceutical composition, and uses of the aggregate, the culturing medium and the composition.

公开(公告)号：US20180177597A1

公开(公告)日：2018-06-28

申请号：US15658992

申请日：2017-07-25

申请人： THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY

发明人： Rebecca Chung ,  Antonio Valdevit ,  Dilhan Kalyon

IPC分类号： A61F2/28 ,  A61L27/56 ,  A61L27/18 ,  A61L27/58 ,  A61L27/38 ,  A61L27/54 ,  C12N5/00 ,  C12N5/077 ,  B33Y80/00 ,  B33Y10/00

CPC分类号： A61F2/2846 ,  A61L27/18 ,  A61L27/3608 ,  A61L27/3821 ,  A61L27/3834 ,  A61L27/3847 ,  A61L27/3895 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L2300/412 ,  A61L2300/64 ,  A61L2300/802 ,  A61L2400/18 ,  A61L2430/02 ,  B33Y10/00 ,  B33Y80/00 ,  C12N5/0062 ,  C12N5/0654 ,  C12N2513/00 ,  C12N2527/00 ,  C12N2533/40 ,  C08L67/04

摘要： A bone repair scaffold having two moduli that match those of the cancellous and cortical bone in a patient receiving a bone graft/implant. The bone repair scaffold possesses increased mechanical properties to sustain physiological loading and biologically active capability to facilitate bone fusion. The bone repair scaffold may be 3D-printed, which allows for a variety of scaffold designs and configurations. Pore size, interconnected porosity, shape, and modulus of the bone repair scaffold may be modified for different bone graft applications, whether it is used as filler for bone cancer resections or trauma, or as a fusion device in cases of surgery. Depending on the defect location of the bone shaft, the relative porosity of the scaffold may be modified to account for changes in cortical bone thickness. A method for treating a bone defect using the bone repair scaffold is also disclosed.

公开(公告)号：US09982232B2

公开(公告)日：2018-05-29

申请号：US14652552

申请日：2013-12-17

申请人： NEWSOUTH INNOVATIONS PTY LIMITED

发明人： John Pimanda ,  Vashe Chandrakanthan

IPC分类号： C12N5/074 ,  C12N5/0775 ,  A61K35/32 ,  A61K35/33 ,  A61K35/35 ,  A61K31/706 ,  A61L27/16 ,  A61L27/38 ,  A61L27/52 ,  A61K35/28 ,  A61K38/18

CPC分类号： C12N5/0662 ,  A61K31/706 ,  A61K35/28 ,  A61K35/32 ,  A61K35/33 ,  A61K35/35 ,  A61K38/1858 ,  A61L27/16 ,  A61L27/3804 ,  A61L27/3834 ,  A61L27/3843 ,  A61L27/3847 ,  A61L27/3852 ,  A61L27/3895 ,  A61L27/52 ,  A61L2300/414 ,  A61L2430/02 ,  C12N2500/40 ,  C12N2501/06 ,  C12N2501/135 ,  C12N2503/02 ,  C12N2506/13 ,  A61K2300/00 ,  C08L23/0853

摘要： The present invention relates to methods for generating mammalian multilineage-potential cells, including mesenchymal stem cells, comprising contacting mammalian somatic cells exhibiting a mature phenotype with PDGF-AB or functional derivative, fragment or mimetic thereof and Azacitidine or functional derivative or analog thereof for a time and under conditions sufficient to induce the transition of the somatic cells to cells exhibiting multilineage differentiative potential. Also provided are uses of said multilineage-potential cells, such as in promoting tissue repair and regeneration.

公开(公告)号：US09765292B2

公开(公告)日：2017-09-19

申请号：US14406043

申请日：2013-06-04

申请人： CELLEC BIOTEK AG ,  UNIVERSITY HOSPITAL OF BASEL

发明人： Elia Piccinini ,  David Wendt ,  Adam Papadimitropoulos ,  Laura Spinelli ,  Stefania Adele Riboldi ,  Francesco Giovanni Greco ,  Peter Iwatschenko

IPC分类号： C12M1/00 ,  A01N1/00 ,  C12N5/00 ,  A61L27/38 ,  C12M1/12 ,  C12N5/0775

CPC分类号： C12M23/40 ,  A61L27/3847 ,  A61L27/3895 ,  C12M23/00 ,  C12M25/14 ,  C12M29/00 ,  C12N5/0062 ,  C12N5/0663 ,  C12N2533/14

摘要： A bioreactor for preferably three-dimensional cell culturing comprises a scaffold chamber, a first tube, a second tube and a first valve with a scaffold adapter, a tube adapter and a medium adapter. The first valve has a housing with a longitudinal female portion ending in an opening and a longitudinal actuator being arranged through the opening of the female portion of the housing such that the actuator is arranged partially inside the housing and partially outside the housing, wherein the actuator of the first valve is axially moveable relative to the housing of the first valve between a first position in which the first valve is in the operation position and a second position in which the first valve is in the medium change position. By providing the actuators in the first valve which is applied by axial movements, operation of the bioreactor can be comparably simple and safe.