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公开(公告)号：US5786332A
公开(公告)日：1998-07-28
申请号：US400983
申请日：1995-03-06
CPC分类号： C07K7/06 , C07K14/68 , C07K14/695 , C07K5/0812 , C07K5/1024 , A61K38/00
摘要： The present invention relates to novel peptides that are potent cytokine restraining agents. In addition, the present invention relates to pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a cytokine restraining agent. Administration of such a cytokine restraining agent to a subject restrains, but does not necessarily suppress, cytokine activity completely. Thus, the present invention provides a method of restraining pathologically elevated cytokine activity in a subject. The invention also provides methods of treating disuse deconditioning and diseases mediated by nitric oxide and cytokines, such as diabetes and glomerulonephritis, a method of organ protection, a method of organ protection, and a method of reducing the negative side effects of cancer chemotherapy, such as nephrotoxicity.
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2.发明授权Cytokine regulatory agents and methods of use in pathologies and conditions associated with altered cytokine levels 失效细胞因子调节剂和与改变的细胞因子水平相关的病理学和病症中使用的方法
公开(公告)号：US5726156A
公开(公告)日：1998-03-10
申请号：US527056
申请日：1995-09-12
申请人： Beverly E. Girten , Ali Andalibi , Amaresh Basu , Patrick Fagan , Richard A. Houghten , Costas C. Loullis , Paul Omholt , Ronald R. Tuttle , Mark J. Suto , Patricia A. Weber
发明人： Beverly E. Girten , Ali Andalibi , Amaresh Basu , Patrick Fagan , Richard A. Houghten , Costas C. Loullis , Paul Omholt , Ronald R. Tuttle , Mark J. Suto , Patricia A. Weber
IPC分类号： A61K38/00 , A61K45/00 , A61P3/00 , A61P3/08 , A61P3/10 , A61P9/00 , A61P11/00 , A61P13/02 , A61P15/00 , A61P29/00 , A61P35/00 , A61P37/00 , A61P43/00 , C07K5/087 , C07K5/117 , C07K5/12 , C07K7/06 , C07K7/64 , C07K14/68 , C07K14/695
CPC分类号： C07K14/695 , C07K14/68 , C07K5/0812 , C07K5/1024 , A61K38/00
摘要： The present invention relates to novel peptides that are potent cytokine regulatory agents. In addition, the present invention relates to pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a cytokine regulatory agent. Administration of such a cytokine regulatory agent to a subject can enhance or restrain cytokine activity. Thus, the present invention provides a method of regulating cytokine activity in a subject having a condition characterized by aberrant or altered cytokine activity. The invention also provides methods of treating such conditions, including, for example, disuse deconditioning, diseases mediated by nitric oxide and cytokines, adverse drug reactions, obesity, septic shock, and adverse side effects due to cancer chemotherapy or occurring as in response to organ transplantation.
摘要翻译： 本发明涉及有效的细胞因子调节剂的新型肽。 此外，本发明涉及包含药学上可接受的载体和细胞因子调节剂的药物组合物。 向受试者施用这样的细胞因子调节剂可以增强或抑制细胞因子活性。 因此，本发明提供一种调节受试者中细胞因子活性的方法，其特征在于异常或改变的细胞因子活性。 本发明还提供了治疗这些病症的方法，包括例如废除解毒，由一氧化氮和细胞因子介导的疾病，药物不良反应，肥胖症，败血性休克以及由于癌症化学疗法或作为对器官的反应而发生的不良副作用 移植。
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公开(公告)号：US06245738B1
公开(公告)日：2001-06-12
申请号：US08336473
申请日：1994-11-09
IPC分类号： A61K3800
CPC分类号： A61K38/08 , C07K5/1024 , C07K14/68 , C07K14/685 , C07K14/695
摘要： The present invention provides novel cytokine restraining agents, which limit or control the biological activity of cytokines. The invention also provides pharmaceutical compositions comprising a cytokine restraining peptide and methods of administering the pharmaceutical composition to a subject. The invention further provides methods for using the novel peptides to restrain cytokine activity in a subject.
摘要翻译： 本发明提供限制或控制细胞因子生物学活性的新型细胞因子抑制剂。 本发明还提供了包含细胞因子抑制肽的药物组合物和向受试者施用药物组合物的方法。 本发明进一步提供了使用新型肽抑制受试者中细胞因子活性的方法。
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4.发明授权Cytokine restraining agents and methods of use in pathologies and conditions associated with altered cytokine levels 失效细胞因子抑制剂和与改变的细胞因子水平相关的病理学和病症中使用的方法
公开(公告)号：US5760001A
公开(公告)日：1998-06-02
申请号：US447143
申请日：1995-05-22
CPC分类号： C07K7/06 , C07K14/68 , C07K14/695 , C07K5/0812 , C07K5/1024 , A61K38/00
摘要： The present invention relates to novel peptides that are potent cytokine restraining agents. In addition, the present invention relates to pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a cytokine restraining agent. Administration of such a cytokine restraining agent to a subject restrains, but does not necessarily suppress, cytokine activity completely. Thus, the present invention provides a method of restraining pathologically elevated cytokine activity in a subject. The invention also provides methods of treating disuse deconditioning and diseases mediated by nitric oxide and cytokines, such as diabetes and glomerulonephritis, a method of organ protection, a method of organ protection, and a method of reducing the negative side effects of cancer chemotherapy, such as nephrotoxicity.
摘要翻译： 本发明涉及有效的细胞因子抑制剂的新型肽。 此外，本发明涉及包含药学上可接受的载体和细胞因子抑制剂的药物组合物。 对受试者施用这种细胞因子抑制剂抑制，但不一定抑制细胞因子活性。 因此，本发明提供抑制受试者中病理升高的细胞因子活性的方法。 本发明还提供了治疗废用脱毒和由一氧化氮和细胞因子如糖尿病和肾小球肾炎介导的疾病，器官保护方法，器官保护方法和降低癌症化学疗法的负面副作用的方法， 作为肾毒性。
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公开(公告)号：US5420109A
公开(公告)日：1995-05-30
申请号：US151534
申请日：1993-11-12
IPC分类号： A61N1/30 , A61K38/00 , A61K38/08 , A61P1/00 , A61P29/00 , A61P37/00 , A61P43/00 , C07K5/117 , C07K7/06 , C07K7/64 , C07K9/00 , C07K14/68 , C07K14/685 , C07K14/695 , C07K5/00 , C07K7/00 , C07K17/00
CPC分类号： A61K38/08 , C07K14/68 , C07K14/685 , C07K14/695 , C07K5/1024
摘要： The present invention provides novel cytokine restraining agents, which limit or control the biological activity of cytokines. The invention also provides pharmaceutical compositions comprising a cytokine restraining peptide and methods of administering the pharmaceutical composition to a subject. The invention further provides methods for using the novel peptides to restrain cytokine activity in a subject.
摘要翻译： 本发明提供限制或控制细胞因子生物学活性的新型细胞因子抑制剂。 本发明还提供了包含细胞因子抑制肽的药物组合物和向受试者施用药物组合物的方法。 本发明进一步提供了使用新型肽抑制受试者中细胞因子活性的方法。
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