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1.发明授权Cytokine regulatory agents and methods of use in pathologies and conditions associated with altered cytokine levels 失效细胞因子调节剂和与改变的细胞因子水平相关的病理学和病症中使用的方法
公开(公告)号：US5726156A
公开(公告)日：1998-03-10
申请号：US527056
申请日：1995-09-12
申请人： Beverly E. Girten , Ali Andalibi , Amaresh Basu , Patrick Fagan , Richard A. Houghten , Costas C. Loullis , Paul Omholt , Ronald R. Tuttle , Mark J. Suto , Patricia A. Weber
发明人： Beverly E. Girten , Ali Andalibi , Amaresh Basu , Patrick Fagan , Richard A. Houghten , Costas C. Loullis , Paul Omholt , Ronald R. Tuttle , Mark J. Suto , Patricia A. Weber
IPC分类号： A61K38/00 , A61K45/00 , A61P3/00 , A61P3/08 , A61P3/10 , A61P9/00 , A61P11/00 , A61P13/02 , A61P15/00 , A61P29/00 , A61P35/00 , A61P37/00 , A61P43/00 , C07K5/087 , C07K5/117 , C07K5/12 , C07K7/06 , C07K7/64 , C07K14/68 , C07K14/695
CPC分类号： C07K14/695 , C07K14/68 , C07K5/0812 , C07K5/1024 , A61K38/00
摘要： The present invention relates to novel peptides that are potent cytokine regulatory agents. In addition, the present invention relates to pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a cytokine regulatory agent. Administration of such a cytokine regulatory agent to a subject can enhance or restrain cytokine activity. Thus, the present invention provides a method of regulating cytokine activity in a subject having a condition characterized by aberrant or altered cytokine activity. The invention also provides methods of treating such conditions, including, for example, disuse deconditioning, diseases mediated by nitric oxide and cytokines, adverse drug reactions, obesity, septic shock, and adverse side effects due to cancer chemotherapy or occurring as in response to organ transplantation.
摘要翻译： 本发明涉及有效的细胞因子调节剂的新型肽。 此外，本发明涉及包含药学上可接受的载体和细胞因子调节剂的药物组合物。 向受试者施用这样的细胞因子调节剂可以增强或抑制细胞因子活性。 因此，本发明提供一种调节受试者中细胞因子活性的方法，其特征在于异常或改变的细胞因子活性。 本发明还提供了治疗这些病症的方法，包括例如废除解毒，由一氧化氮和细胞因子介导的疾病，药物不良反应，肥胖症，败血性休克以及由于癌症化学疗法或作为对器官的反应而发生的不良副作用 移植。
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公开(公告)号：US20070265224A1
公开(公告)日：2007-11-15
申请号：US11818666
申请日：2007-06-14
申请人： Phillip Cook , Guangyi Wang , Thomas Bruice , Nicholas Boyle , Janet Leeds , Jennifer Brooks , Marija Prhavc , Maria Ariza , Patrick Fagan , Yi Jin , Vivek Rajwanshi , Kathleen Tucker
发明人： Phillip Cook , Guangyi Wang , Thomas Bruice , Nicholas Boyle , Janet Leeds , Jennifer Brooks , Marija Prhavc , Maria Ariza , Patrick Fagan , Yi Jin , Vivek Rajwanshi , Kathleen Tucker
IPC分类号： A61K31/7072 , A61K31/505 , A61K31/7076 , A61P31/12 , A61P35/00 , C07H19/06 , C07H19/16 , C07D239/02 , A61P31/18 , A61P31/00 , A61K31/7068
摘要： The present invention relates to nucleoside diphosphate mimics and nucleoside triphosphate mimics, which contain diphosphate or triphosphate moiety mimics and optionally sugar-modifications and/or base-modifications. The nucleotide mimics of the present invention, in a form of a pharmaceutically acceptable salt, a pharmaceutically acceptable prodrug, or a pharmaceutical formulation, are useful as antiviral, antimicrobial, and anticancer agents. The present invention provides a method for the treatment of viral infections, microbial infections, and proliferative disorders. The present invention also relates to pharmaceutical compositions comprising the compounds of the present invention optionally in combination with other pharmaceutically active agents.
摘要翻译： 本发明涉及核苷二磷酸模拟物和核苷三磷酸模拟物，其含有二磷酸酯或三磷酸酯部分模拟物和任选的糖修饰和/或碱基修饰。 本发明的核苷酸模拟物以药学上可接受的盐，药学上可接受的前药或药物制剂的形式可用作抗病毒，抗微生物剂和抗癌剂。 本发明提供了一种治疗病毒感染，微生物感染和增殖性疾病的方法。 本发明还涉及包含任选与其它药物活性剂组合的本发明化合物的药物组合物。
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公开(公告)号：US20070259832A1
公开(公告)日：2007-11-08
申请号：US11818990
申请日：2007-06-14
申请人： Phillip Cook , Guangyi Wang , Thomas Bruice , Nicholas Boyle , Janet Leeds , Jennifer Brooks , Marija Prhavc , Maria Ariza , Patrick Fagan , Yi Jin , Vivek Rajwanshi , Kathleen Tucker
发明人： Phillip Cook , Guangyi Wang , Thomas Bruice , Nicholas Boyle , Janet Leeds , Jennifer Brooks , Marija Prhavc , Maria Ariza , Patrick Fagan , Yi Jin , Vivek Rajwanshi , Kathleen Tucker
IPC分类号： A61K31/711 , C07H19/04
摘要： The present invention relates to nucleoside diphosphate mimics and nucleoside triphosphate mimics, which contain diphosphate or triphosphate moiety mimics and optionally sugar-modifications and/or base-modifications. The nucleotide mimics of the present invention, in a form of a pharmaceutically acceptable salt, a pharmaceutically acceptable prodrug, or a pharmaceutical formulation, are useful as antiviral, antimicrobial, and anticancer agents. The present invention provides a method for the treatment of viral infections, microbial infections, and proliferative disorders. The present invention also relates to pharmaceutical compositions comprising the compounds of the present invention optionally in combination with other pharmaceutically active agents.
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