Collection assemblies, laminates, and autosensor assemblies for use in transdermal sampling systems
    7.
    发明申请
    Collection assemblies, laminates, and autosensor assemblies for use in transdermal sampling systems 有权
    采集组件,层压板和自动传感器组件,用于透皮采样系统

    公开(公告)号:US20020004640A1

    公开(公告)日:2002-01-10

    申请号:US09810917

    申请日:2001-03-16

    Applicant: Cygnus, Inc.

    CPC classification number: A61B5/1486

    Abstract: The invention relates generally to consumable components of a device used for continually or continuously measuring the concentration of target chemical analytes present in a biological system. More particularly, the invention relates to collection assemblies, laminate structures, and autosensor assemblies, which are used in connection with a transdermal sampling device. In one aspect, the invention includes autosensor assemblies which include laminate structures, electrode assemblies, and support trays. One important application of the invention involves an autosensor assembly for use in a blood glucose monitoring device.

    Abstract translation: 本发明一般涉及用于连续或连续地测量存在于生物系统中的目标化学分析物的浓度的装置的可消耗部件。 更具体地,本发明涉及与透皮采样装置结合使用的收集组件,层压结构和自动传感器组件。 一方面,本发明包括包括层压结构,电极组件和支撑盘的自动传感器组件。 本发明的一个重要应用涉及一种用于血糖监测装置的自动传感器组件。

    Biosensor and methods of use thereof
    8.
    发明申请
    Biosensor and methods of use thereof 有权
    生物传感器及其使用方法

    公开(公告)号:US20040167383A1

    公开(公告)日:2004-08-26

    申请号:US10778721

    申请日:2004-02-13

    Applicant: Cygnus, Inc.

    Abstract: An automated system for continual transdermal extraction of analytes present in a biological system is provided. The system can be used for detecting and/or measuring the concentration of the analyte using an electrochemical biosensor detection means. The system optionally uses reverse iontophoresis to carry out the continual transdermal extraction of the analytes.

    Abstract translation: 提供了一种用于连续透皮提取生物系统中存在的分析物的自动化系统。 该系统可用于使用电化学生物传感器检测装置来检测和/或测量分析物的浓度。 该系统可选择使用反向离子电渗法进行分析物的连续经皮提取。

    Hydrogel formulations for use in electroosmotic extraction and detection of glucose
    9.
    发明申请
    Hydrogel formulations for use in electroosmotic extraction and detection of glucose 审中-公开
    用于电渗提取和葡萄糖检测的水凝胶制剂

    公开(公告)号:US20040062759A1

    公开(公告)日:2004-04-01

    申请号:US10664467

    申请日:2003-09-17

    Applicant: Cygnus, Inc.

    CPC classification number: C12Q1/00 A61K49/0006 A61N1/0436 A61N1/0496

    Abstract: A hydrogel patch is disclosed which is comprised of a polymeric material which forms a gel with water with the material being present in an amount of about 0.5% to 40% by weight based on the weight of the patch. Electrical conductively of the water is increased by the addition of an electrolyte. The patch comprises an enzyme which is capable of catalyzing a reaction with a biomedically important molecule such as glucose. Glucose drawn into the patch undergoes a reaction with the aid of the enzyme and the hydrogen peroxide released flows through the electrically conductivity of the water and may react at an electrode surface to generate a signal related to the amount of glucose entering the patch. The patch is also preferably comprised of a buffer which maintains the pH of the patch in the range of from about 3 to 9, and may be further comprised of a cross-linking agent, a biocide, a humectant, and a surfactant. The patch is preferably in the form of a thin (5 nullm-50 mils), flat circular disc (0.5 to 10 cm2 of area) which will conform to the contours of human skin and may have a non-woven fabric embedded therein and removable release liners on each surface.

    Abstract translation: 公开了一种水凝胶贴片,其由与水形成凝胶的聚合物材料组成,该材料的存在量为贴剂重量的约0.5重量%至40重量%。 通过添加电解液可以增加导电性。 贴剂包含能够催化与生物医学上重要的分子如葡萄糖的反应的酶。 吸入贴剂的葡萄糖借助于酶发生反应,释放的过氧化氢流过水的电导率,并可在电极表面反应,产生与进入贴剂的葡萄糖量相关的信号。 贴剂还优选由将贴剂的pH保持在约3至9范围内的缓冲剂组成,并且还可以包含交联剂,杀生物剂,保湿剂和表面活性剂。 该贴片优选为薄(5m-50密耳)扁平圆盘(0.5至10cm 2面积)的形式,其将符合人体皮肤的轮廓,并且可以具有嵌入的无纺织物 其中每个表面上都有可拆卸的隔离衬垫。

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