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公开(公告)号:US10906018B2
公开(公告)日:2021-02-02
申请号:US15741820
申请日:2016-07-05
发明人: Yongliang Zhao , Martin Möller , Xiaomin Zhu
IPC分类号: A61K8/11 , B01J13/18 , A61K8/25 , C08L83/12 , C08L83/06 , A61Q19/00 , C08F2/18 , C08F20/14 , C08G77/18 , C08G77/46 , F28D20/02
摘要: The present invention relates to a method for enclosing either hydrophobic or hydrophilic substances in silica-based micro- and nanocapsules via emulsion techniques. More specifically, it relates to a method for the preparation of 0.01-100 μm, particularly 0.01-10 μm, silica-based microcapsules containing up to 99% (w/w) payload using a silica precursor polymer, polyalkoxysiloxane (PAOS), preferentially polyalkylalkoxysiloxane (R-PAOS), which acts not only as a silica source but also an emulsifier. In order to obtain mechanically stable capsules, the conversion of PAOS or R-PAOS is accompanied with the solidification of the organic phase. For the encapsulation of hydrophobic substances, oil-in-water emulsions are formed. The formation of water-in-oil-in-water double emulsions is required to encapsulate hydrophilic compounds.
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公开(公告)号:US20180200689A1
公开(公告)日:2018-07-19
申请号:US15741820
申请日:2016-07-05
发明人: Yongliang ZHAO , Martin MÖLLER , Xiaomin ZHU
CPC分类号: B01J13/185 , A61K8/11 , A61K8/25 , A61K2800/10 , A61K2800/412 , A61Q19/00 , C08F2/18 , C08F20/14 , C08G77/18 , C08G77/46 , C08L83/06 , C08L83/12 , F28D20/023 , C08F12/08 , C08F2/44 , C08L25/06 , C08L83/04
摘要: The present invention relates to a method for enclosing either hydrophobic or hydrophilic substances in silica-based micro- and nanocapsules via emulsion techniques. More specifically, it relates to a method for the preparation of 0.01-100 μm, particularly 0.01-10 μm, silica-based microcapsules containing up to 99% (w/w) payload using a silica precursor polymer, polyalkoxysiloxane (PAOS), preferentially polyalkylalkoxysiloxane (R-PAOS), which acts not only as a silica source but also an emulsifier. In order to obtain mechanically stable capsules, the conversion of PAOS or R-PAOS is accompanied with the solidification of the organic phase. For the encapsulation of hydrophobic substances, oil-in-water emulsions are formed. The formation of water-in-oil-in-water double emulsions is required to encapsulate hydrophilic compounds.
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公开(公告)号:US20210238236A1
公开(公告)日:2021-08-05
申请号:US17253291
申请日:2019-06-21
发明人: Ulrich SCHWANEBERG , Nursen SÖZER , Alan MERTENS , Mehdi DAVARI DOLATABADI , Felix JAKOB , Shohana ISLAM , Lina APITIUS
IPC分类号: C07K14/435 , C07K14/31 , C12Q1/42 , G01N33/44
摘要: The present invention pertains to a novel fusion protein and/or fusion peptide, preferably for use in the separation from and/or detection in an environment of one or more target polymers or plastics, e.g., one or more target polymer fragments and/M or particles or target plastic fragments and/or particles, preferably wherein the one or more target polymer particles or target plastic particles are microplastics; a method of preparing such novel fusion protein and/or fusion peptide, a system and kit comprising the novel fusion protein and/or fusion peptide and a (polymer or non-polymer) carrier or carrier system, a use of the novel fusion protein and/or fusion peptide or of a system and kit as mentioned in the separation from and/or detection in an environment of one or more target polymers or plastics, e.g., one or more target polymer fragments and/or particles or target plastic fragments and/or particles, preferably wherein the one or more target polymer particles or target plastic particles are microplastics; a method of separation of one or more target polymers or plastics from an environment, e.g., one or more target polymer fragments and/or particles or target plastic fragments and/or particles, and a method of detection of one or more target polymers or plastics in an environment, e.g., one or more target polymer fragments and/or particles or target plastic fragments and/or particles, preferably wherein the one or more target polymer particles or target plastic particles are microplastics.
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公开(公告)号:US11779681B2
公开(公告)日:2023-10-10
申请号:US17350695
申请日:2021-06-17
CPC分类号: A61L27/446 , A61L27/042 , A61L27/48 , A61L27/52 , A61L2400/06
摘要: The present invention relates to a macroscopically alignable, injectable, soft hydrogel composition which is able to form an anisotropic structure in vivo, after injection, to generate healthy functioning tissue and regenerate injured or diseased soft tissue.
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公开(公告)号:US20220072069A1
公开(公告)日:2022-03-10
申请号:US17413437
申请日:2019-12-12
IPC分类号: A61K35/747 , A61K9/70 , A61K35/744 , A61K35/745 , A61P31/04
摘要: A topical pharmaceutical or cosmetic formulation is disclosed, comprising two polymer membranes enclosing probiotic bacteria having antimicrobial activities against skin pathogens sandwiched therebetween, one of the membranes being semipermeable and having a pore size which does not allow penetration of the bacteria, and medical and cosmetic uses thereof. Preferably the probiotic bacteria are of the order Lactobacillales, most preferably of the strain L. plantarum 8P-A3 (DSM 32835).
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公开(公告)号:US20210308331A1
公开(公告)日:2021-10-07
申请号:US17350695
申请日:2021-06-17
摘要: The present invention relates to a macroscopically alignable, injectable, soft hydrogel composition which is able to form an anisotropic structure in vivo, after injection, to generate healthy functioning tissue and regenerate injured or diseased soft tissue.
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公开(公告)号:US11071806B2
公开(公告)日:2021-07-27
申请号:US16331454
申请日:2017-09-25
摘要: The present invention relates to a macroscopically alignable, injectable, soft hydrogel composition which is able to form an anisotropic structure in vivo, after injection, to generate healthy functioning tissue and regenerate injured or diseased soft tissue.
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