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1.
公开(公告)号:US08653255B2
公开(公告)日:2014-02-18
申请号:US12897523
申请日:2010-10-04
申请人: Sanjay Jain , Peter Laing , Gregory Gregoriadis , Dale Howard Hreczuk-Hirst , Ioannis Papaioannou
发明人: Sanjay Jain , Peter Laing , Gregory Gregoriadis , Dale Howard Hreczuk-Hirst , Ioannis Papaioannou
IPC分类号: A61K31/702 , A61K31/726 , C07H5/06
CPC分类号: A61K47/4823 , A61K31/702 , A61K31/726 , A61K38/27 , A61K38/28 , A61K39/44 , A61K47/61 , A61K47/6807 , C07H3/06 , C07H5/06 , C07H15/04 , C07K17/12 , C08B37/00 , C08B37/0006 , C08B37/006 , C08B37/0063
摘要: Derivatives are synthesized of starting materials, usually polysaccharides, having sialic acid at the reducing terminal end, in which the reducing terminal unit is transformed into an aldehyde group. Where the polysaccharide has a sialic acid unit at the non-reducing end it may be passivated, for instance by converting into hydroxyl-substituted moiety. The derivatives may be reacted with substrates, for instance containing amine or hydrazine groups, to form non-cross-linked polysialylated compounds. The substrates may, for instance, be therapeutically useful drugs peptides or proteins or drug delivery systems.
摘要翻译: 衍生物由还原性末端具有唾液酸的原料(通常为多糖)合成,其中还原末端单元转化为醛基。 当多糖在非还原末端具有唾液酸单元时,其可以被钝化,例如通过转化成羟基取代的部分。 衍生物可以与底物反应,例如含有胺或肼基团,以形成非交联的聚唾液酸化化合物。 底物可以例如是治疗上有用的药物肽或蛋白质或药物递送系统。
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2.
公开(公告)号:US20110082077A1
公开(公告)日:2011-04-07
申请号:US12897523
申请日:2010-10-04
申请人: Sanjay JAIN , Peter LAING , Gregory GREGORIADIS , Dale Howard HRECZUK-HIRST , Ioannis PAPAIOANNOU
发明人: Sanjay JAIN , Peter LAING , Gregory GREGORIADIS , Dale Howard HRECZUK-HIRST , Ioannis PAPAIOANNOU
IPC分类号: A61K38/00 , C07H1/00 , A61K31/715 , C07K14/00 , A61P3/10
CPC分类号: A61K47/4823 , A61K31/702 , A61K31/726 , A61K38/27 , A61K38/28 , A61K39/44 , A61K47/61 , A61K47/6807 , C07H3/06 , C07H5/06 , C07H15/04 , C07K17/12 , C08B37/00 , C08B37/0006 , C08B37/006 , C08B37/0063
摘要: Derivatives are synthesised of starting materials, usually polysaccharides, having sialic acid at the reducing terminal end, in which the reducing terminal unit is transformed into an aldehyde group. Where the polysaccharide has a sialic acid unit at the non-reducing end it may be passivated, for instance by converting into hydroxyl-substituted moiety. The derivatives may be reacted with substrates, for instance containing amine or hydrazine groups, to form non-cross-linked polysialylated compounds. The substrates may, for instance, be therapeutically useful drugs peptides or proteins or drug delivery systems.
摘要翻译: 衍生物由还原性末端具有唾液酸的原料(通常为多糖)合成,其中还原末端单元转化为醛基。 当多糖在非还原末端具有唾液酸单元时,其可以被钝化,例如通过转化成羟基取代的部分。 衍生物可以与底物反应,例如含有胺或肼基团,以形成非交联的聚唾液酸化化合物。 底物可以例如是治疗上有用的药物肽或蛋白质或药物递送系统。
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3.
公开(公告)号:US07807824B2
公开(公告)日:2010-10-05
申请号:US10568043
申请日:2004-08-12
申请人: Sanjay Jain , Peter Laing , Gregory Gregoriadis , Dale Howard Hreczuk-Hirst , Ioannis Papaioannou
发明人: Sanjay Jain , Peter Laing , Gregory Gregoriadis , Dale Howard Hreczuk-Hirst , Ioannis Papaioannou
IPC分类号: A61K31/715 , C07H1/00 , C08B37/00 , C12P19/04
CPC分类号: A61K47/4823 , A61K31/702 , A61K31/726 , A61K38/27 , A61K38/28 , A61K39/44 , A61K47/61 , A61K47/6807 , C07H3/06 , C07H5/06 , C07H15/04 , C07K17/12 , C08B37/00 , C08B37/0006 , C08B37/006 , C08B37/0063
摘要: Derivatives are synthesised of starting materials, usually polysaccharides, having sialic acid at the reducing terminal end, in which the reducing terminal unit is transformed into an aldehyde group. Where the polysaccharide has a sialic acid unit at the non-reducing end it may be passivated, for instance by converting into hydroxyl-substituted moiety. The derivatives may be reacted with substrates, for instance containing amine or hydrazine groups, to form non-cross-linked polysialylated compounds. The substrates may, for instance, be therapeutically useful drugs peptides or proteins or drug delivery systems.
摘要翻译: 衍生物由还原性末端具有唾液酸的原料(通常为多糖)合成,其中还原末端单元转化为醛基。 当多糖在非还原末端具有唾液酸单元时,其可以被钝化,例如通过转化成羟基取代的部分。 衍生物可以与底物反应,例如含有胺或肼基团,以形成非交联的聚唾液酸化化合物。 底物可以例如是治疗上有用的药物肽或蛋白质或药物递送系统。
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公开(公告)号:US20100221808A1
公开(公告)日:2010-09-02
申请号:US12717073
申请日:2010-03-03
申请人: Dale Howard Hreczuk-Hirst , Sanjay Jain , Peter Laing , Gregory Gregoriadis , Ioannis Papaioannou
发明人: Dale Howard Hreczuk-Hirst , Sanjay Jain , Peter Laing , Gregory Gregoriadis , Ioannis Papaioannou
CPC分类号: C08B37/0006 , A61K31/715 , A61K47/61 , A61K47/68 , C07K1/006 , C07K1/1077 , C07K1/13 , C07K14/001 , C07K17/10 , C08B37/00 , C12N9/96
摘要: A polysialic acid compound is reacted with a hetero-bifunctional reagent to introduce a pendant functional group for site-specific conjugation to sulfhydryl groups, for instance side chains of cysteine units in drugs, drug delivery systems, proteins or peptides. The functional group is, for instance, an N-maleimide group.
摘要翻译: 将多唾液酸化合物与异双功能试剂反应以引入用于位点特异性缀合的侧链官能团,例如巯基,例如药物,药物递送系统,蛋白质或肽中半胱氨酸单元的侧链。 官能团是例如N-马来酰亚胺基团。
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公开(公告)号:US07691826B2
公开(公告)日:2010-04-06
申请号:US10568111
申请日:2004-08-12
申请人: Dale Howard Hreczuk-Hirst , Sanjay Jain , Peter Laing , Gregory Gregoriadis , Ioannis Papaioannou
发明人: Dale Howard Hreczuk-Hirst , Sanjay Jain , Peter Laing , Gregory Gregoriadis , Ioannis Papaioannou
IPC分类号: A61K31/7008 , A61K31/7012 , A61K31/7028 , A61K31/7056 , A61K31/715
CPC分类号: C08B37/0006 , A61K31/715 , A61K47/61 , A61K47/68 , C07K1/006 , C07K1/1077 , C07K1/13 , C07K14/001 , C07K17/10 , C08B37/00 , C12N9/96
摘要: A polysialic acid compound is reacted with a hetero-bifunctional reagent to introduce a pendant functional group for site-specific conjugation to sulfhydryl groups, for instance side chains of cysteine units in drugs, drug delivery systems, proteins or peptides. The functional group is, for instance, an N-maleimide group.
摘要翻译: 将多唾液酸化合物与异双功能试剂反应以引入用于位点特异性缀合的侧链官能团,例如巯基,例如药物,药物递送系统,蛋白质或肽中半胱氨酸单元的侧链。 官能团是例如N-马来酰亚胺基团。
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