公开(公告)号：US09821278B2

公开(公告)日：2017-11-21

申请号：US15506654

申请日：2015-08-25

申请人： The Governors of the University of Alberta

发明人： Carlo David Montemagno ,  Jeffrey Germain ,  Kyle Minor ,  Sinoj Abraham ,  Hiofan Hoi ,  Yuan He

IPC分类号： B01D71/82 ,  C02F1/44 ,  C02F101/00 ,  C07K14/705 ,  C07K17/08 ,  C08G75/23 ,  C02F101/12 ,  C02F101/16 ,  C02F101/30 ,  C02F101/38

CPC分类号： B01D71/82 ,  C02F1/44 ,  C02F2101/12 ,  C02F2101/16 ,  C02F2101/306 ,  C02F2101/308 ,  C02F2101/38 ,  C02F2103/08 ,  C07B2200/11 ,  C07K14/47 ,  C07K14/705 ,  C07K17/00 ,  C07K17/08 ,  C07K17/12 ,  C08G75/23

摘要： Constructs having membrane proteins stabilized by functionalized beta-sheet peptides are provided. The constructs can be associated with or covalently linked to supports. The support can be a membrane. The membrane can be used to selectively move desired particles from one side of the membrane to the other while impeding passage of undesired particles through the membrane. Methods of making and using such constructs and membranes are provided.

公开(公告)号：US09670254B2

公开(公告)日：2017-06-06

申请号：US14804882

申请日：2015-07-21

申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

发明人： Steven J. Norris

IPC分类号： A61K39/02 ,  A61K39/00 ,  G01N33/53 ,  C07K14/20 ,  G01N33/569 ,  C07K17/08 ,  C07K17/12 ,  C08G69/48 ,  G01N33/68

CPC分类号： C07K14/20 ,  A61K39/00 ,  A61K39/02 ,  C07K17/08 ,  C07K17/12 ,  C08G69/48 ,  G01N33/56911 ,  G01N33/6854 ,  G01N2333/20 ,  G01N2469/20 ,  G01N2800/26 ,  Y02A50/40 ,  Y02A50/401 ,  Y02A50/57

摘要： The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borrelia, the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded amino acid sequences, application of the DNA and amino acid sequences to the production of polypeptides as antigens for immunoprophylaxis, immunotherapy, and immunodiagnosis. Also disclosed are the use of the nucleic acid sequences as probes or primers for the detection of organisms causing Lyme disease, relapsing fever, or related disorders, and kits designed to facilitate methods of using the described polypeptides, DNA segments and antibodies.

公开(公告)号：US20160208008A1

公开(公告)日：2016-07-21

申请号：US14855184

申请日：2015-09-15

申请人： ALPER BIOTECH, LLC

发明人： Özge ALPER

IPC分类号： C07K16/28 ,  A61K51/10 ,  A61K39/395 ,  C07K17/12 ,  A61K47/48 ,  C12N7/00 ,  A61K49/00 ,  C07K14/705

CPC分类号： C07K16/2881 ,  A61K39/3955 ,  A61K47/6913 ,  A61K49/0058 ,  A61K51/1027 ,  C07K14/70582 ,  C07K16/18 ,  C07K16/3069 ,  C07K17/12 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/41 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2319/30 ,  C12N7/00 ,  G01N33/57434 ,  G01N33/57484 ,  G01N2333/70582 ,  G01N2800/56

摘要： Some embodiments are directed to monoclonal antibodies (mAbs) that bind to transferrin (TF) and transferrin receptor 1 (TFRC), hybridoma lines that secrete these antibodies, and the use of these antibodies to detect TF and TFRC antigens. Some other embodiments are directed to methods and uses for detecting cancer and iron deficiency anemia, as well as methods and uses for distinguishing between early and late stage prostate cancer.

摘要翻译： 一些实施方案涉及结合转铁蛋白（TF）和转铁蛋白受体1（TFRC），分泌这些抗体的杂交瘤系的单克隆抗体（mAb），以及这些抗体用于检测TF和TFRC抗原的用途。 一些其它实施方案涉及用于检测癌症和缺铁性贫血的方法和用途，以及区分早期和晚期前列腺癌的方法和用途。

公开(公告)号：US08283458B2

公开(公告)日：2012-10-09

申请号：US13324357

申请日：2011-12-13

申请人： Steven J. Norris

发明人： Steven J. Norris

IPC分类号： C07H21/04 ,  C07H21/02 ,  A61K39/02

CPC分类号： C07K14/20 ,  A61K39/00 ,  A61K39/02 ,  C07K17/08 ,  C07K17/12 ,  C08G69/48 ,  G01N33/56911 ,  G01N33/6854 ,  G01N2333/20 ,  G01N2469/20 ,  G01N2800/26 ,  Y02A50/40 ,  Y02A50/401 ,  Y02A50/57

摘要： The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borrelia, the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded amino acid sequences, application of the DNA and amino acid sequences to the production of polypeptides as antigens for immunoprophylaxis, immunotherapy, and immunodiagnosis. Also disclosed are the use of the nucleic acid sequences as probes or primers for the detection of organisms causing Lyme disease, relapsing fever, or related disorders, and kits designed to facilitate methods of using the described polypeptides, DNA segments and antibodies.

摘要翻译： 本发明涉及编码病原性疏螺旋体的Vmp样多肽的DNA序列，重组载体中的DNA序列用于表达多肽的用途，编码的氨基酸序列，将DNA和氨基酸序列应用于产生多肽作为抗原 用于免疫预防，免疫治疗和免疫诊断。 还公开了使用核酸序列作为检测引起莱姆病，复发性发热或相关病症的生物的探针或引物，以及旨在促进使用所述多肽，DNA区段和抗体的方法的试剂盒。

公开(公告)号：US4959461A

公开(公告)日：1990-09-25

申请号：US436163

申请日：1989-11-14

申请人： Manssur Yalpani ,  Magdy M. Abdel-Malik

发明人： Manssur Yalpani ,  Magdy M. Abdel-Malik

IPC分类号： C07K17/12 ,  C08B11/20 ,  C08B15/06 ,  C08B37/00 ,  C12N11/12

CPC分类号： C12N11/12 ,  C07K17/12 ,  C08B11/20 ,  C08B15/06 ,  C08B37/0033 ,  Y10S530/81 ,  Y10S530/813

摘要： New Amines and amides of carboxylated polysaccharides having the nitrogen of the amido and amino groups directly attached to the polysaccharides and method of making same, based on reacting in solution a material having carboxyl-containing polysaccharides, such as carboxymethyl cellulose, with ammonium donors having the general formula >NH such as primary and secondary amine reagents and with or without a reducing agent to obtain amides or amines. These products may be used for instance in biological separations, for the immobilization of proteins, for the removal of metal ions, a thickeners, and as suspension agents.

摘要翻译： 具有直接连接到多糖上的酰氨基和氨基的氮的羧基多糖的新胺和酰胺及其制备方法，基于溶液中具有含羧基的多糖（例如羧甲基纤维素）的材料与具有 通式> NH如伯胺和仲胺试剂，有或没有还原剂，以获得酰胺或胺。 这些产品可用于例如生物分离，用于固定蛋白质，去除金属离子，增稠剂和悬浮剂。

公开(公告)号：US20170102380A1

公开(公告)日：2017-04-13

申请号：US15122470

申请日：2015-03-05

申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (CEA)

发明人： Julie CREDOU ,  Thomas BERTHELOT ,  Rita FADDOUL

IPC分类号： G01N33/548 ,  G01N33/545 ,  C07K17/12

CPC分类号： G01N33/548 ,  C07K17/08 ,  C07K17/12 ,  G01N33/545

摘要： The immobilization of biomolecules on a non-functionalized carrier by irradiating the biomolecule-impregnated carrier with a light of a wavelength of at least 340 nm.

公开(公告)号：US20160102124A1

公开(公告)日：2016-04-14

申请号：US14804882

申请日：2015-07-21

申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

发明人： Steven J. NORRIS

IPC分类号： C07K14/20 ,  C08G69/48 ,  G01N33/68 ,  C07K17/12 ,  C07K17/08

CPC分类号： C07K14/20 ,  A61K39/00 ,  A61K39/02 ,  C07K17/08 ,  C07K17/12 ,  C08G69/48 ,  G01N33/56911 ,  G01N33/6854 ,  G01N2333/20 ,  G01N2469/20 ,  G01N2800/26 ,  Y02A50/40 ,  Y02A50/401 ,  Y02A50/57

摘要： The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borrelia, the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded amino acid sequences, application of the DNA and amino acid sequences to the production of polypeptides as antigens for immunoprophylaxis, immunotherapy, and immunodiagnosis. Also disclosed are the use of the nucleic acid sequences as probes or primers for the detection of organisms causing Lyme disease, relapsing fever, or related disorders, and kits designed to facilitate methods of using the described polypeptides, DNA segments and antibodies.

公开(公告)号：US20140220605A1

公开(公告)日：2014-08-07

申请号：US14257613

申请日：2014-04-21

申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

发明人： Steven J. NORRIS

IPC分类号： G01N33/569 ,  C07K14/20

CPC分类号： C07K14/20 ,  A61K39/00 ,  A61K39/02 ,  C07K17/08 ,  C07K17/12 ,  C08G69/48 ,  G01N33/56911 ,  G01N33/6854 ,  G01N2333/20 ,  G01N2469/20 ,  G01N2800/26 ,  Y02A50/40 ,  Y02A50/401 ,  Y02A50/57

摘要： The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borrelia, the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded amino acid sequences, application of the DNA and amino acid sequences to the production of polypeptides as antigens for immunoprophylaxis, immunotherapy, and immunodiagnosis. Also disclosed are the use of the nucleic acid sequences as probes or primers for the detection of organisms causing Lyme disease, relapsing fever, or related disorders, and kits designed to facilitate methods of using the described polypeptides, DNA segments and antibodies.

摘要翻译： 本发明涉及编码病原性疏螺旋体的Vmp样多肽的DNA序列，重组载体中的DNA序列用于表达多肽的用途，编码的氨基酸序列，将DNA和氨基酸序列应用于产生多肽作为抗原 用于免疫预防，免疫治疗和免疫诊断。 还公开了使用核酸序列作为检测引起莱姆病，复发性发热或相关病症的生物的探针或引物，以及旨在促进使用所述多肽，DNA区段和抗体的方法的试剂盒。

公开(公告)号：US20110082077A1

公开(公告)日：2011-04-07

申请号：US12897523

申请日：2010-10-04

申请人： Sanjay JAIN ,  Peter LAING ,  Gregory GREGORIADIS ,  Dale Howard HRECZUK-HIRST ,  Ioannis PAPAIOANNOU

发明人： Sanjay JAIN ,  Peter LAING ,  Gregory GREGORIADIS ,  Dale Howard HRECZUK-HIRST ,  Ioannis PAPAIOANNOU

IPC分类号： A61K38/00 ,  C07H1/00 ,  A61K31/715 ,  C07K14/00 ,  A61P3/10

CPC分类号： A61K47/4823 ,  A61K31/702 ,  A61K31/726 ,  A61K38/27 ,  A61K38/28 ,  A61K39/44 ,  A61K47/61 ,  A61K47/6807 ,  C07H3/06 ,  C07H5/06 ,  C07H15/04 ,  C07K17/12 ,  C08B37/00 ,  C08B37/0006 ,  C08B37/006 ,  C08B37/0063

摘要： Derivatives are synthesised of starting materials, usually polysaccharides, having sialic acid at the reducing terminal end, in which the reducing terminal unit is transformed into an aldehyde group. Where the polysaccharide has a sialic acid unit at the non-reducing end it may be passivated, for instance by converting into hydroxyl-substituted moiety. The derivatives may be reacted with substrates, for instance containing amine or hydrazine groups, to form non-cross-linked polysialylated compounds. The substrates may, for instance, be therapeutically useful drugs peptides or proteins or drug delivery systems.

摘要翻译： 衍生物由还原性末端具有唾液酸的原料（通常为多糖）合成，其中还原末端单元转化为醛基。 当多糖在非还原末端具有唾液酸单元时，其可以被钝化，例如通过转化成羟基取代的部分。 衍生物可以与底物反应，例如含有胺或肼基团，以形成非交联的聚唾液酸化化合物。 底物可以例如是治疗上有用的药物肽或蛋白质或药物递送系统。

公开(公告)号：US07807824B2

公开(公告)日：2010-10-05

申请号：US10568043

申请日：2004-08-12

申请人： Sanjay Jain ,  Peter Laing ,  Gregory Gregoriadis ,  Dale Howard Hreczuk-Hirst ,  Ioannis Papaioannou

发明人： Sanjay Jain ,  Peter Laing ,  Gregory Gregoriadis ,  Dale Howard Hreczuk-Hirst ,  Ioannis Papaioannou

IPC分类号： A61K31/715 ,  C07H1/00 ,  C08B37/00 ,  C12P19/04

CPC分类号： A61K47/4823 ,  A61K31/702 ,  A61K31/726 ,  A61K38/27 ,  A61K38/28 ,  A61K39/44 ,  A61K47/61 ,  A61K47/6807 ,  C07H3/06 ,  C07H5/06 ,  C07H15/04 ,  C07K17/12 ,  C08B37/00 ,  C08B37/0006 ,  C08B37/006 ,  C08B37/0063

摘要： Derivatives are synthesised of starting materials, usually polysaccharides, having sialic acid at the reducing terminal end, in which the reducing terminal unit is transformed into an aldehyde group. Where the polysaccharide has a sialic acid unit at the non-reducing end it may be passivated, for instance by converting into hydroxyl-substituted moiety. The derivatives may be reacted with substrates, for instance containing amine or hydrazine groups, to form non-cross-linked polysialylated compounds. The substrates may, for instance, be therapeutically useful drugs peptides or proteins or drug delivery systems.

摘要翻译： 衍生物由还原性末端具有唾液酸的原料（通常为多糖）合成，其中还原末端单元转化为醛基。 当多糖在非还原末端具有唾液酸单元时，其可以被钝化，例如通过转化成羟基取代的部分。 衍生物可以与底物反应，例如含有胺或肼基团，以形成非交联的聚唾液酸化化合物。 底物可以例如是治疗上有用的药物肽或蛋白质或药物递送系统。