-
公开(公告)号：US5640010A
公开(公告)日：1997-06-17
申请号：US438707
申请日：1995-05-11
申请人： Damian Twerenbold
发明人： Damian Twerenbold
CPC分类号： H01J49/025 , C12Q1/6872
摘要： A mass spectrometer with phonon sensitive cryogenic particle detector determines the masses of macromolecules, proteins, large peptides, long DNA-fragments and polymers. The kinetic energy of the electrostatically accelerated charged macromolecule is absorbed in the cryogenic particle detector thereby exciting phonons which are detected by phonon sensors. The macromolecules are detected in the single particle counting mode with a sensitivity independent of their respective masses. The mass spectrometer contains a single-channel cryogenic particle detector providing high sensitivity. The mass spectrometer contains a spatially resolving multi-channel cryogenic detector array providing both high sensitivity and high throughput. The mass spectrometer consists of a vacuum vessel in which is a magnet, a mass separator, a feed through and a phonon sensitive cryogenic detector array. The cryogenic detector array consists of an absorber and a specified number of phonon sensors. The mass separator is placed in the magnetic field of the magnet and the feed through, on electrical potential U1, but electrically insulated from the magnet. The cryogenic detector array is on electrical ground potential U2. The macromolecules are accelerated by the voltage difference U1-U2 and reach the cryogenic detector array with a kinetic energy proportional to U1-U2. The cryogenic detector array is cooled to its operating temperature T2 by being thermally mounted to a cold finger of the cryostat with bath temperature T2. The mass of the macromolecule is determined by the spatial and time information provided by the cryogenic detector array.
摘要翻译： 具有声子敏感的低温颗粒检测器的质谱仪确定大分子，蛋白质，大肽，长DNA片段和聚合物的质量。 静电加速电荷大分子的动能被低温颗粒检测器吸收，从而激发由声子传感器检测到的声子。 在单粒子计数模式下检测大分子，灵敏度与其各自的质量无关。 质谱仪包含提供高灵敏度的单通道低温颗粒检测器。 质谱仪包含空间分辨的多通道低温检测器阵列，提供高灵敏度和高通量。 质谱仪由真空容器组成，其中是磁体，质量分离器，进料通道和声子敏感的低温检测器阵列。 低温检测器阵列由吸收器和指定数量的声子传感器组成。 质量分离器放置在磁体的磁场中，并通过电位U1进给，但与磁体电绝缘。 低温检测器阵列处于电地电位U2。 大分子由电压差U1-U2加速，并以与U1-U2成比例的动能达到低温检测器阵列。 将低温检测器阵列通过热浴安装到具有浴温度T2的低温恒温器的冷指状物上而冷却至其工作温度T2。 大分子的质量由低温检测器阵列提供的空间和时间信息确定。
-
公开(公告)号：US06710334B1
公开(公告)日：2004-03-23
申请号：US10347988
申请日：2003-01-20
申请人： Damian Twerenbold
发明人： Damian Twerenbold
IPC分类号： B01D5944
CPC分类号： H01J49/424 , H01J49/025 , H01J49/0481
摘要： This invention relates to a quadrupol ion trap mass spectrometer with improved sensitivity for massive molecules by using cryogenic particle detectors as molecule detectors. Cryogenic particle detectors have a mass independent detection efficiency and do not show a decrease of detection efficiency for increasing molecule mass as compared to ionizing detectors which are used in common quadrupol ion trap mass spectrometers.
摘要翻译： 本发明涉及通过使用低温颗粒检测器作为分子检测器，对大分子具有改进的灵敏度的四极离子阱质谱仪。 与普通四极离子阱质谱仪中使用的电离检测器相比，低温颗粒检测器具有质量独立的检测效率，并且不显示提高分子质量的检测效率的降低。
-
公开(公告)号：US06523762B1
公开(公告)日：2003-02-25
申请号：US09762891
申请日：2001-02-08
IPC分类号： A62C3102
CPC分类号： B41J2/1628 , B41J2/14233 , B41J2/1617 , B41J2/162 , B41J2/1629 , B41J2/1631 , B41J2/1642 , B41J2002/14387 , B41J2002/14475
摘要： The invention relates to a micromechanically produced nozzle for producing reproducibly small drops which consist of a liquid container delimited by a silicon structure and a pyrex structure. The silicon structure is a silicon wafer consisting of a silicon oxide layer (SiO2) and a silicon nitride layer (SI3N4). The wafer has a nozzle of silicon oxide (SiO3), which forms a nozzle opening of a liquid container. The liquid is fed into the liquid container through a channel formed in the pyrex structure. A disk made of a piezoelectric material exerts a pressure on the liquid in the container, which passes through the nozzle in the form of a drop.
摘要翻译： 本发明涉及一种微机械制造的喷嘴，用于生产可重复地小的液滴，其由由硅结构和发烟结构限定的液体容器组成。 硅结构是由氧化硅层（SiO 2）和氮化硅层（SI3N4）组成的硅晶片。 晶片具有形成液体容器的喷嘴开口的氧化硅（SiO 3）喷嘴。 液体通过形成在发泡结构中的通道进入液体容器。 由压电材料制成的盘对容器中的液体施加压力，该液体以液滴的形式通过喷嘴。
-
-
搜索结果
3 条记录 (耗时 0.01 秒)
