OXADIAZOLINE LIGANDS FOR MODULATING THE EXPRESSION OF EXOGENOUS GENES VIA AN ECDYSONE RECEPTOR COMPLEX
    3.
    发明申请
    OXADIAZOLINE LIGANDS FOR MODULATING THE EXPRESSION OF EXOGENOUS GENES VIA AN ECDYSONE RECEPTOR COMPLEX 有权
    用于通过ECDYSONE受体复合物调节外源基因表达的OXADIAZOLINE LIGANDS

    公开(公告)号:US20070287731A1

    公开(公告)日:2007-12-13

    申请号:US11838090

    申请日:2007-08-13

    CPC classification number: C07D271/06 C07D413/12

    Abstract: The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene.

    Abstract translation: 本发明涉及用于基于核受体的诱导型基因表达系统的非甾体配体,以及调节外源基因表达的方法,其中蜕皮激素受体复合物包含:DNA结合结构域; 配体结合域; 反式激活域 并且配体与包含以下的DNA构建体接触:外源基因和应答元件; 其中外源基因处于响应元件的控制之下,并且在配体存在下DNA结合结构域与响应元件的结合导致基因的激活或抑制。

    POWER-BASED DYNAMIC ADJUSTMENT OF MEMORY MODULE BANDWIDTH

    公开(公告)号:US20190042121A1

    公开(公告)日:2019-02-07

    申请号:US16112461

    申请日:2018-08-24

    Abstract: In embodiments, a memory controller includes a sensor poller and a proportional integral controller (PIC) coupled to the sensor poller. The sensor poller is to obtain a temperature and a power of a memory module (MM) operated by the controller, and the PIC is to: dynamically set at least one bandwidth limit for the MM, based, at least in part, on a relationship between a temperature of the MM, a power of the MM and a bandwidth of the MM. In embodiments, the dynamically set bandwidth limit defines the power of the MM at which the MM operates for a predetermined temperature limit. In embodiments, a system includes a memory controller and a dual in-line memory module (DIMM) operated by it.

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