公开(公告)号：US07390879B2

公开(公告)日：2008-06-24

申请号：US10226739

申请日：2002-08-23

Applicant: Avi J. Ashkenazi ,  Kevin P. Baker ,  David A. Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Ivar J. Kljavin ,  Jennie P. Mather ,  Mary A. Napier ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  Timothy A. Stewart ,  Daniel Tumas ,  Colin K. Watanabe ,  P. Mickey Williams ,  William I. Wood ,  Zemin Zhang

Inventor： Avi J. Ashkenazi ,  Kevin P. Baker ,  David A. Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Ivar J. Kljavin ,  Jennie P. Mather ,  Mary A. Napier ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  Timothy A. Stewart ,  Daniel Tumas ,  Colin K. Watanabe ,  P. Mickey Williams ,  William I. Wood ,  Zemin Zhang

IPC: C07K14/00 ,  C07K7/00 ,  A61K39/00

CPC classification number: C07K14/47

Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US07317092B2

公开(公告)日：2008-01-08

申请号：US10066273

申请日：2002-02-01

Applicant: Avi J. Ashkenazi ,  Kevin P. Baker ,  David A. Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Ivar J. Kljavin ,  Jennie P. Mather ,  Mary A. Napier ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  Timothy A. Stewart ,  Daniel Tumas ,  Colin K. Watanabe ,  P. Mickey Williams ,  William I. Wood ,  Zemin Zhang

Inventor： Avi J. Ashkenazi ,  Kevin P. Baker ,  David A. Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Ivar J. Kljavin ,  Jennie P. Mather ,  Mary A. Napier ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  Timothy A. Stewart ,  Daniel Tumas ,  Colin K. Watanabe ,  P. Mickey Williams ,  William I. Wood ,  Zemin Zhang

IPC: C07K16/00 ,  C07K17/00

CPC classification number: A61K38/17 ,  C07H21/04 ,  C07K14/435 ,  C07K16/40 ,  C12N5/06 ,  C12N9/00 ,  C12P21/02 ,  C12P21/06 ,  G01N33/53 ,  Y02A50/473

Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US06387657B1

公开(公告)日：2002-05-14

申请号：US09182145

申请日：1998-10-29

Applicant: David A. Botstein ,  Robert L. Cohen ,  Audrey D. Goddard ,  Austin L. Gurney ,  Kenneth J. Hillan ,  David A. Lawrence ,  Arnold J. Levine ,  Diane Pennica ,  Margaret Ann Roy ,  William I. Wood

Inventor： David A. Botstein ,  Robert L. Cohen ,  Audrey D. Goddard ,  Austin L. Gurney ,  Kenneth J. Hillan ,  David A. Lawrence ,  Arnold J. Levine ,  Diane Pennica ,  Margaret Ann Roy ,  William I. Wood

IPC: C12N1512

CPC classification number: C07K14/47 ,  C07K14/475 ,  C07K16/18 ,  C07K16/22 ,  C07K16/30 ,  C07K16/32 ,  C07K2317/73 ,  C07K2317/74 ,  C12Q1/6886 ,  C12Q2600/136

Abstract: Wnt-1-Induced Secreted Proteins (WISPs) are provided, whose genes are induced at least by Wnt-1. Also provided are nucleic acid molecules encoding those polypeptides, as well as vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides, and methods for producing the polypeptides.

Abstract translation: 提供了Wnt-1诱导的分泌蛋白（WISP），其基因至少被Wnt-1诱导。 还提供了编码那些多肽的核酸分子，以及包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的多肽的嵌合多肽分子，与多肽结合的抗体，以及用于产生多肽的方法。