公开(公告)号：US20090191184A1

公开(公告)日：2009-07-30

申请号：US12287810

申请日：2008-10-14

申请人： Avi J. Ashkenazi ,  David Botstein ,  Kelly H. Dodge ,  Audrey Goddard ,  Austin L. Gurney ,  Kyung Jin Kim ,  David A. Lawrence ,  Robert Pitti ,  Margaret A. Roy ,  Daniel B. Tumas ,  William I. Wood

发明人： Avi J. Ashkenazi ,  David Botstein ,  Kelly H. Dodge ,  Audrey Goddard ,  Austin L. Gurney ,  Kyung Jin Kim ,  David A. Lawrence ,  Robert Pitti ,  Margaret A. Roy ,  Daniel B. Tumas ,  William I. Wood

IPC分类号： A61K38/17 ,  A61K39/395

CPC分类号： C07K14/70578 ,  A01K2217/05 ,  C07H21/04

摘要： A TNFR homolog, identified as DcR3, is provided. Nucleic acid molecules encoding DcR3, chimeric molecules and antibodies to DcR3 are also provided.

摘要翻译： 提供了标识为DcR3的TNFR同源物。 还提供了编码DcR3的核酸分子，嵌合分子和DcR3的抗体。

公开(公告)号：US07470771B2

公开(公告)日：2008-12-30

申请号：US10677471

申请日：2003-10-02

申请人： Kevin P. Baker ,  David Botstein ,  Dan L. Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Ivar J. Kijavin ,  Mary A. Napier ,  Margaret Ann Roy ,  Daniel Tumas ,  William I. Wood

发明人： Kevin P. Baker ,  David Botstein ,  Dan L. Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Ivar J. Kijavin ,  Mary A. Napier ,  Margaret Ann Roy ,  Daniel Tumas ,  William I. Wood

IPC分类号： C07K14/435 ,  C07K14/52

CPC分类号： A61K38/17 ,  C07H21/04 ,  C07K14/47 ,  C12Q1/68

摘要： The present invention is directed to secreted and transmembrane polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

摘要翻译： 本发明涉及分泌和跨膜多肽以及编码这些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

公开(公告)号：US07208308B2

公开(公告)日：2007-04-24

申请号：US09903640

申请日：2001-07-11

申请人： Avi Ashkenazi ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Sherman Fong ,  Wei-Giang Gao ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Ivar J. Kljavin ,  Jennie P. Mather ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  Timothy A. Stewart ,  Daniel Tumas ,  P. Mickey Williams ,  William I. Wood

发明人： Avi Ashkenazi ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Sherman Fong ,  Wei-Giang Gao ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Ivar J. Kljavin ,  Jennie P. Mather ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  Timothy A. Stewart ,  Daniel Tumas ,  P. Mickey Williams ,  William I. Wood

IPC分类号： C12N9/48

CPC分类号： C07K14/47 ,  G01N33/68 ,  G01N2333/485

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US07087738B2

公开(公告)日：2006-08-08

申请号：US09907942

申请日：2001-07-17

申请人： David Botstein ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Margaret Ann Roy ,  William I. Wood

发明人： David Botstein ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Margaret Ann Roy ,  William I. Wood

IPC分类号： C12N15/12 ,  C12N15/63 ,  C12N1/15 ,  C12N1/21 ,  C12N5/10

CPC分类号： C07K14/705 ,  C07K14/47

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US20060148076A1

公开(公告)日：2006-07-06

申请号：US11353554

申请日：2006-02-13

申请人： David Botstein ,  Audrey Goddard ,  Austin Gurney ,  Paul Godowski ,  Kenneth Hillan ,  Margaret Roy ,  William Wood

发明人： David Botstein ,  Audrey Goddard ,  Austin Gurney ,  Paul Godowski ,  Kenneth Hillan ,  Margaret Roy ,  William Wood

IPC分类号： A61K39/12 ,  C12N5/06 ,  C12N5/16

CPC分类号： C07K14/47

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US07070955B2

公开(公告)日：2006-07-04

申请号：US09989733

申请日：2001-11-20

申请人： Avi J. Ashkenazi ,  Kevin P. Baker ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Sherman Fong ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Ivar J. Kljavin ,  Mary A. Napier ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  Timothy A. Stewart ,  Daniel Tumas ,  Colin K. Watanabe ,  P. Mickey Williams ,  William I. Wood ,  Zemin Zhang

发明人： Avi J. Ashkenazi ,  Kevin P. Baker ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Sherman Fong ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Ivar J. Kljavin ,  Mary A. Napier ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  Timothy A. Stewart ,  Daniel Tumas ,  Colin K. Watanabe ,  P. Mickey Williams ,  William I. Wood ,  Zemin Zhang

IPC分类号： C12N15/00 ,  C12N5/00 ,  C07K21/00

CPC分类号： C07K14/4747 ,  C07K14/47

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US20060127983A1

公开(公告)日：2006-06-15

申请号：US11296155

申请日：2005-12-06

申请人： Kevin Baker ,  David Botstein ,  Dan Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Mary Gerritsen ,  Audrey Goddard ,  Paul Godowski ,  J. Grimaldi ,  Austin Gurney ,  Kenneth Hillan ,  Ivar Kljavin ,  Mary Napier ,  Margaret Roy ,  Daniel Tumas ,  William Wood

发明人： Kevin Baker ,  David Botstein ,  Dan Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Mary Gerritsen ,  Audrey Goddard ,  Paul Godowski ,  J. Grimaldi ,  Austin Gurney ,  Kenneth Hillan ,  Ivar Kljavin ,  Mary Napier ,  Margaret Roy ,  Daniel Tumas ,  William Wood

IPC分类号： A61K38/17 ,  C07H21/04 ,  C12P21/06 ,  C12N9/00 ,  C12N5/06 ,  C12N1/18

CPC分类号： C07K14/475 ,  A61K38/00 ,  C07K14/47 ,  C07K14/4703 ,  C07K14/70578 ,  C07K16/18 ,  C07K2317/24 ,  C07K2319/00 ,  C07K2319/02 ,  C12N2799/026 ,  G01N33/5005 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/5085 ,  G01N33/57484 ,  G01N33/68

摘要： The present invention is directed to secreted and transmembrane polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US20050084935A1

公开(公告)日：2005-04-21

申请号：US10897360

申请日：2004-07-21

申请人： Avi Ashkenazi ,  Kevin Baker ,  David Botstein ,  Luc Desnoyers ,  Dan Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary Gerritsen ,  Audrey Goddard ,  Paul Godowski ,  J. Grimaldi ,  Austin Gurney ,  Kenneth Hillan ,  Ivar Kljavin ,  Sophia Kuo ,  Mary Napier ,  James Pan ,  Nicholas Paoni ,  Margaret Roy ,  David Shelton ,  Timothy Stewart ,  Daniel Tumas ,  P. Williams ,  William Wood

发明人： Avi Ashkenazi ,  Kevin Baker ,  David Botstein ,  Luc Desnoyers ,  Dan Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary Gerritsen ,  Audrey Goddard ,  Paul Godowski ,  J. Grimaldi ,  Austin Gurney ,  Kenneth Hillan ,  Ivar Kljavin ,  Sophia Kuo ,  Mary Napier ,  James Pan ,  Nicholas Paoni ,  Margaret Roy ,  David Shelton ,  Timothy Stewart ,  Daniel Tumas ,  P. Williams ,  William Wood

IPC分类号： A61K38/00 ,  C07K14/47 ,  C07K14/705 ,  G01N33/50 ,  G01N33/574 ,  G01N33/68 ,  C12P21/02 ,  C07H21/04 ,  C12N9/00

CPC分类号： G01N33/5008 ,  A61K38/00 ,  C07K14/47 ,  C07K14/4703 ,  C07K14/705 ,  C07K2319/00 ,  C07K2319/30 ,  C12N2799/026 ,  C12N2799/027 ,  G01N33/5011 ,  G01N33/502 ,  G01N33/57484 ,  G01N33/68 ,  G01N33/6845

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US20050079577A1

公开(公告)日：2005-04-14

申请号：US10893802

申请日：2004-07-16

申请人： Avi Ashkenazi ,  Kevin Baker ,  David Botstein ,  Luc Desnoyers ,  Dan Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary Gerritsen ,  Audrey Goddard ,  Paul Godowski ,  J. Grimaldi ,  Austin Gurney ,  Kenneth Hillan ,  Ivar Kljavin ,  Sophia Kuo ,  Mary Napier ,  James Pan ,  Nicholas Paoni ,  Margaret Roy ,  David Shelton ,  Timothy Stewart ,  Daniel Tumas ,  P. Williams ,  William Wood

发明人： Avi Ashkenazi ,  Kevin Baker ,  David Botstein ,  Luc Desnoyers ,  Dan Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary Gerritsen ,  Audrey Goddard ,  Paul Godowski ,  J. Grimaldi ,  Austin Gurney ,  Kenneth Hillan ,  Ivar Kljavin ,  Sophia Kuo ,  Mary Napier ,  James Pan ,  Nicholas Paoni ,  Margaret Roy ,  David Shelton ,  Timothy Stewart ,  Daniel Tumas ,  P. Williams ,  William Wood

IPC分类号： A61K38/00 ,  C07K14/47 ,  C07K14/705 ,  C07H21/04 ,  C12N9/00

CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K14/4703 ,  C07K14/705 ,  C07K2319/00 ,  C07K2319/30 ,  C12N2799/026 ,  C12N2799/027

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US06635468B2

公开(公告)日：2003-10-21

申请号：US09907794

申请日：2001-07-17

申请人： Avi Ashkenazi ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Ivar J. Kljavin ,  Jennie P. Mather ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  Timothy A. Stewart ,  Daniel Tumas ,  P. Mickey Williams ,  William I. Wood

发明人： Avi Ashkenazi ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Ivar J. Kljavin ,  Jennie P. Mather ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  Timothy A. Stewart ,  Daniel Tumas ,  P. Mickey Williams ,  William I. Wood

IPC分类号： C12N121

CPC分类号： C07K14/47 ,  C07K14/705 ,  C07K2319/00

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.